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DERM 1 > Derm viruses > Flashcards

Derm viruses Flashcards

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Dermatology Board Prep flashcards
1
Q

How does a wart actually form in HPV infections?

A

when the virus infects basal cells (stratum basale) it stimulates cell division

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2
Q

How do ya differentate smallpox from chickenpox clinically?

A

synchronous lesions in smallpox, variable staged lesions in chickenpox

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2
Q

Between chickenpox and smallpox, which has lesions that would more closely resemble molluscum?

A

smallpox because they are often umbilicated

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3
Q

Name 2 derm viruses that may result in the formation of syncytia

A

Herpes and measles

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4
Q

Regarding the appearance of the rash (not evolution of) how is measles different from german measles?

A

Germn measles is lighter in color (pink)

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4
Q

What is the most important historical feature of HHV-6?

A

Extremely high fever that abruptly stops and then there is a maculopapular rash

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5
Q

Compare and contrast the incubation period of measles and german measles

A

German measles is 2-3 weeks, measles is only 9 days

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5
Q

What virus causes hand, foot, and mouth? What kinda, sorta, but not really all that similar disease is caused by fungus?

A

Coxsackie A16; two foot, one hand which is a tinea infection

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5
Q

What is the key feature of ALL herpes viruses?

A

latency! i.e. nerve ganglia for HSV and VZV, B cells for EBV, etc? B/T cells for HHV-6

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6
Q

What viral family is measles in?

A

paramyxoviridae

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7
Q

How are HPV and MCV transmitted?

A

direct contact and fomites

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7
Q

What profession may be likely to get Orf infections?

A

Taxidermists

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7
Q

Where will you find a Cowdry Type A body? What does it tell you about the entirety of the herpesviridae family?

A

Intranuclear, HERPES VIRUSES REPLICATE IN THE NUCLEUS

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8
Q

Genetic makeup of A) B19 B) HHV-6

A

A) naked ssDNA B) enveloped ds DNA

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9
Q

How does Dr. Kell pronouce “rash”?

A

Raysh

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10
Q

Name the 3 enveloped DNA virus families

A

Hepadnaviridae, herpesviridae, and poxviridae

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10
Q

Please describe the evolution of the measles illness

A

Starts with a cold/flu like Sx 9-10 d after infection, in this they will have the classic cough, conjunctivitis, coryza, and PHOTOPHOBIA? Then they will get the rash behind ears and down (with koplick spots in mouth) 3 days later and it will progress to the feet by 6 d

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10
Q

Severe complications of viral infection of eczematous skin occur with ________

A

HERPES!

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12
Q

Which strains of HPV are responsible for plantar warts?

A

1 and 4, flat and grow inward

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12
Q

If you are not vaccinated against VZV, what is the probability you will be infected when exposed to someone with it?

A

90%

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13
Q

When did routine smallpox vaccinations stop in America? When was it GLOBALLY eradicated?

A

1972, 1979

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14
Q

What is the transmission of A) measles B) rubella and C) B19

A

ALL = RESP DROPLETS

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16
Q

What kind of virus is molluscum contagiosum?

A

enveloped DS DNA virus (complex shape)

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16
Q

What is the most common complication of shingles?

A

post-herpetic neuralgia

18
Q

What is the vaccine type for measles?

A

MMR, live-attenuated

18
Q

What cells are infected by HPV? B19?

A

HPV infects basal cells of skin, B19 infects erythroid progenitor cells

19
Q

What is erythema infectiosum? Exanthem subitum?

A

B19, HHV-6

20
Q

Which of the childhood exanthems will have a multinucleate giant cell under microscopy?

A

measles

21
Q

In what sense is the rash of B19 similar to that in lupus?

A

It is on the face and is sensitive to sunlight

23
Q

What family of virus is measles? German measles?

A

rubeola = paramyxoviridae, rubella = togaviridae

25
Q

Describe how HPV infects

A

it is a naked dsDNA virus that infects the basal layers of skin but replicates in the mature layers

27
Q

What kind of virus is orf and how is it transmitted?

A

enveloped DS DNA virus; sheep, goats, and reindeer

28
Q

What virus causes herpangina?

A

Coxsackie A–this is basically hand, foot, and mouth without the hand and foot. And it isn’t caused by the same serotype? So I guess it’s actually completely different. Whatever.

30
Q

How is HPV transmitted?

A

direct contact and fomites

31
Q

What virus causes herpetic whitlow? Population at risk?

A

HSV; dental hygenists who don’t understand the concept of a glove

32
Q

Where do the following replicate A) HPV B) HHV-6 C) B19 D) HHV-8

A

A) mature keratinocytes (infects basal) B) T and B cells C) erythroid precursor cells D) vascular endothelial cells

34
Q

Which strains of HPV are responsible for dysplasia of the cervix and white plaques

A

16 and 18

35
Q

What is the genetic makeup for HHV-6 and HHV-8?

A

ds DNA, enveloped

36
Q

What kind of virus is smallpox?

A

small pox = enveloped dsDNA

37
Q

What is the major demographic you are concerned about in terms of complications, for B19?

A

sickle cell (and, though not mentioned, thalassemias as well)

38
Q

Name the 3 naked DNA virus families

A

Papovaviridae, Adenoviridae, and Parvoviridae

40
Q

Which strains of HPV are responsible for warts on fingers and knees?

A

2, 3, 10

41
Q

What kind of virus are the Coxsackie viruses?

A

naked ss RNA picornaviruses

43
Q

Name the 3 dermatologic viruses that do not involve systemic spread

A

Molluscum contagiosum (can be a marker of HIV), HPV, and ORF

44
Q

What are the 2 major complications of measles?

A

Pneumonia and Subacute Sclerosing Panencephalitis

45
Q

Which strains of HPV are most responsible for genital warts

A

6 and 11

46
Q

How is smallpox transmitted? Chickenpox?

A

RESPIRATORY DROPLETS

47
Q

How is smallpox transmitted? How does it spread throughout the body?

A

Respiratory droplets, spreads via lymphatics

48
Q

Which dermatologic virus is vaccinated using a vaccine containing a different virus than that which is being vaccinated against?

A

Smallpox is vaccinated for with a live cowpox vaccine

49
Q

If you have a biopsy with syncytia (and it is a derm question) how can you differentiate between herpes and measles WITHOUT clinical Hx?

A

Look for a Cowdry Type A body in the newclaus

51
Q

Name the 4 dermatologic viruses that have systemic spread and an infectious rash

A

HSV-1,2, VZV, Variola, and Coxsackievirus

52
Q

Genetic makeup of A) Measles B) rubella and C) B19

A

A) enveloped ssRNA B) enveloped ssRNA C) naked ss DNA

53
Q

Why is possible to achieve lifelong immunity with measles?

A

there is only 1 antigenic type of measles

54
Q

What kind of virus is measles? What family? What is the transmission? Incubation period?

A

enveloped ssRNA, paramyxoviridae, respiratory droplets, 9-10 d

55
Q

What family is molluscum contagiosum in?

A

poxviridae

56
Q

Name the 4 dermatologic viruses that have systemic spread and a non-infectious rash

A

HHV-6, HHV-8, measles, and rubellla

57
Q

If a woman has rubella while pregnant, what is the likely outcome for the baby?

A

low birth weight, cataracts, deafness, MR, heart defects, diabetes (mulberry muffin)

58
Q

What virus causes a blistering “rash” and is a picornavirus?

A

Coxsackie A and A16

59
Q

Name the classic 5 childhood exanthems

A

rubella (german measles), rubeola (normal measles), roseola (HHV-6), chickenpox (VZV), and 5th disease or Parvovirus B19

DERM 1 (7 decks)

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