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DERM 1 > Derm Histo > Flashcards

Derm Histo Flashcards

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Dermatology Board Prep flashcards
1
Q

What kind of epithelium lines the duct of eccrine sweat glands?

A

stratified cuboidal

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2
Q

Which layer of the epidermis secretes tonofilaments? In which layer do the tonofilaments become tonofibrils?

A

stratum basale, stratum spinosum

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2
Q

What do Pacinian corpusles detect? What makes up the inner core? Outer core?

A

vibratory pressure and mechanical stimuli? Inner = Schwann cells, Outer = endoneurium

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3
Q

What kind of cells make up the stratum germinativum?

A

columnar

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4
Q

How are the cells of the stratum spinsoum connected to one another? What effect does this have on their shape?

A

by desmosomes? It gives them a spiny look when the cells shrink for histo prep since the connections remain but the cell shrinks

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4
Q

What causes thermoregulatory sweating? Emotional sweating?

A

cholinergic and adrenergic stimulation of eccrine glands, respectively

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5
Q

Which layer of the epidermis contains high levels of keratohyalin granules?

A

Stratum granulosum

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5
Q

What are “Langer’s lines”?

A

They are lines of tension formed via the Type I collagen and elastin present in the reticular dermal layer

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5
Q

Where will you find melanocytes?

A

stratum basale

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6
Q

What is pigment donation?

A

When the tips of the melanocytes containing melanin are phagocytosed by keratinocytes

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7
Q

What epithelium lines the duct of apocrine sweat glands?

A

stratified cuboidal

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9
Q

Which structures are responsible for fingerprints?

A

dermal papillae

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9
Q

What structures are notable for forming the lipid envelope of skin cells?

A

lamellar bodies secreted to the outside of the cell

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11
Q

What gives the stratum granulosum its basophilic color?

A

keratohyaline granules

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12
Q

T/F: the epidermis is vascularized

A

false that is the point of the dermal papillae, they extend up to the abutting epidermis and from there nutrients travel via diffusion

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13
Q

T/F: nuclei are present in the stratum lucidum of thin skin but not thick skin

A

false, first of all the stratum lucidum is only ever present in thick skin, second there are no nuclei in the stratum lucidum = the cells are dead

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14
Q

Which sweat glands are located “everywhere”? Where are they not located?

A

eccrine (merocrine secretion); rubor labii and external genitalia

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15
Q

Mechanism of secretion of sebaceous glands

A

holocrine

16
Q

Melanin production is increased by what hormone? What parent molecule does this come from?

A

MSH, comes from POMC so associated with ACTH? recall this is why there is hyperpigmentation in Addison’s dz

18
Q

What are the “spines” in the stratum spinosum?

A

Desmosomes

19
Q

what is the name of the edge of skin covering the nail root?

A

eponychium

20
Q

Where will you find the matrix cells of the hair follicle?

A

around the dermal papilla

21
Q

What collagen fibers make up the dermal papillae? What sensory nerve endings might you find in here? Myelinated or unmyelinated?

A

Type I and II; Meissner’s corpuscles, myelinated? the only unmyelinated ones are C fibers

22
Q

What are the 3 cell types of the secretory segment of an eccrine sweat gland?

A

clear cells to secrete the watery component, dark cells to secrete protein, and myoepithelial cells to push it all along

23
Q

What connects the epidermis to the dermis?

A

hemidesmosomes

24
Q

what connects the epidermis to the dermis? What connects the cells of the stratum spinosum to one another?

A

hemidesmosomes, desmosomes

26
Q

What do Merkel cells detect? Myelinated or unmyelinated?

A

pressure? Myelinated the only ones not myelinated are C fibers

27
Q

Where will you find Merkel Cells?

A

in the stratum basale

28
Q

Langerhans cells come from what parent cell (ultimately)?

A

CD34 pluripotent hematopoietic stem cell

29
Q

What layer of the nail is the formative layer?

A

nail matrix

30
Q

How can you differentiate a Langerhans cell from a melanocyte?

A

Melanocytes are located in the stratum basale and Langerhans cells are located in the stratum spinosum

31
Q

How are Langerhans cells connected to the keratinocytes?

A

They arent

32
Q

Name 2 modified sebaceous glands

A

Glands of Moll on the eyelid and Ceruminous glands (wax) of ear canal

33
Q

What is contained in the invagination of the inferior segment of the hair follicle? Why is it important?

A

dermal papillae, this provides nutrients to the growing hair

34
Q

Where will you find Meissner’s corpuscles?

A

IN THE DERMAL PAPILLAE

35
Q

Which layer is the skin-nail junction?

A

hyponychium

37
Q

Where is the melanin in a melanocyte contained?

A

melanosomes

38
Q

If you were to poke a hole in the skin, why would it be elliptical rather than round?

A

The Langer’s lines in the reticular layer of the dermis form lines of tension

39
Q

How are the melanocytes attached to keratinocytes?

A

They arent, the migrated in from neural crest and just kind of chill there

40
Q

What kind of muscle makes up the arrector pili muscles?

A

smooth muscle

41
Q

How is the lumen of apocrine and eccrine glands different?

A

lumen of apocrine are wider

42
Q

What are the 3 layers of the internal root sheath?

A

outer Henles layer of cuboidal cells, then huxley’s layer which is 1-2 layers of squamous cells, on the inside is the cuticle of the hair shaft

43
Q

What 2 keratohyalin granules are present in the stratum granulosum?

A

trichohyalin and filaggrin

DERM 1 (7 decks)

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