derm terms

Question 1

pemphis vulgaris

Answer 1

mouth ulcers (vulgar)
auto antibodies against DESMOSOMES (desmoglein 3 and 1) -->flaccid bullae

intraepidermal cleavage and acantholysis (detached keratinocytes)
“tombstoning”

hemidesmosomes connect keratin to basement membrane

Question 2

bullous pemphigoid

Answer 2

hemidesmosomes, not mouth involvement

hemidesmosomes connect keratin to basment membrane

shows subepidermal cleavage on histo with linear Ig at BM

TENSE bullae

Question 3

adherin junctions

Answer 3

cadherins
req calcium
connects actin cytoskeletons

Question 4

layers of epidermis

Answer 4

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keratin is under basal layer (basal layer has stem cells)

Question 5

dermatomyositis

Answer 5

malar (SLE like) rash + gottron papules + heliotrope rash
-myopathies
-increase risk of occult malignancy
CD4 t cells around perimysial inflammation and atrophy

Question 6

difference in immune response between polymyositis and dermatomyositis

Answer 6

poly= CD8 with endomysial
dermato = CD4 with perimysial inflammation

Question 7

CREST

Answer 7

s= systemic sclerosis
C= calcium increase
R= raynauds
E= esophageal dysmotility
S= sclerodactyly
T= telengectasias