derm/neuro/endo/HO Flashcards
what is the pathological mechanism of action of toxic epidermal necrolysis?
apoptosis of keratinocytes
what is first line treatment for trigeminal neuralgia?
carbamazepine
what is the protein affected in DMD?
dystrophin
what is the most common malignant brain tumor in children?
medulloblastoma
what do we give people for prophylaxis for malaria?
ato-pro
what is another name for vasovagal syncope?
neruocardiogenic syncope
What is the patho of Mystethneia Gravis?
What happens with repeated contraction?
what will happen to the action potential with nerve stimualtion?
Treatment?
antibiodies against post synpatic ACH receptors
fatigues out
decreases
Acetylcholoneesterase inhbiotrs
what is the patho of lambert eaton?
what happens with continued use?
what happens to the action potential with nerve stimulation?
what cancer is strongly assocaited with lambert eaton?
antiboides against pre calcium recptors
stronger
increased
small cell lung cancer
what is the most common form of cancer in chidlren>
ALL
in DKA, what over what potassum level do we give insulin to reduce it?
5.2
what is the most important difference between pemphigus vulgaris and bullous pemphigoid?
pemphigus is much more serious and positive nik signs
what are the two main diagnosis when working up a ring enhancing lesion in the brain?
management?
abscess or cancer
image guided biopsy
two meds to give for thyroid storm?
beta blocker and PTU
what is the most common infection causing erythema multiforme?
herpes
what is the image of choice for MS?
MRI Brain with T2 weighted
classic physical exam finding for lead poisoning?
diagnosis is with?
3 meds to treat it?
wrist or foot drop
blood level
Succ, EDTA and dimercaprol
what is the timeframe of treatment for shingles
within 72 hours, then it becomes supportive
acute MS treatment?
chronic MS treatment?
steroids
beta interferon and glat
what will be the distinguishing factor between candida infection with daper and irritant dermatitis?
skin folds for yeast
treatment of GBS?
IVIG and plasmaphersis
what is the most common cause of primary hyperaldosterone?
how to treat?
idiopathic adrenal hyperplasia
aldosterne blockers, spiro or eplerenone
what 3 things are lost with anterior cord syndrome?
voluntary movement
temp and pain
what is the med of choice for graves disease during pregnancy?
PTU
what protein being expressed on lymphocytes is highly sensitive for CLL?
CD5
what is the slang term for seborrheic dermatitis?
dandruff
what do you need to do before LP for meningitis?
CT
what is neonatal cephalic pustulosis?
baby acne
If I see elevated gastrin with GERD symptoms, what is my thought process for the exam?
high gastric acid from gastrinoma in the duodenum, zollinger, causing PUD
what are the 3 lab vaulues for euthyroid sick syndrome?
tsh normal
t3 low
t4 normal
if bromocriptine doesnt work for prolcatin beig up, what is next med to use?
cabergoline
how to best workup a thyroid nodule?
get a tsh and ultrasound
if the tsh is normal or high, get fine needle
if it is low, radioactive scan
what tumor do most patients with mysthenia gravis have and what is treatment?
thymoma
surgery
in graves disease, what are the antibodies attacking?
tsh receptor
treatment of SIADH begins with what?
fluid restriction
diagnosis of diabetes is made with any of the following 3 criteria?
fasting over 126
random over 200
a1c over 6.4
when do we treat subclinical hypothyrdidm?
symptoms are present
mild acne, what is first line?
topical retinoids
3 assocaited side effects of MM that I need to know for the exam?
anemia, hypercalcemia, and renal failure
If I see old person or alcoholic found down, what do i need to think about what happened to their head and what will CT show?
subdural, crescent shaped
what can be a long term consequence of bacterial men in kids?
hearing loss
what is the most common primary central nervous system tumor and what layer do they arise from?
meningioma
arachnoid
what is responsible for the jerking movements during seiures?
glutamate
what to remember about lithium induced condition?
nephrogenic diabetes insipidus
alpha synuclein protein, and lewy bodies, what am I thinking?
parkinsons, low dopamine
Beta amyloid protein?
alzheimers, low achetylcholine
Tau Protein?
alzheimers
Prion Proteins?
C Jakob disease
boy is late on puberty and cant smell, what am I thinking?
kallman
3 meds for alzheimers?
when to give what?
denepezil, stigmine and memantine
need to give memantine in severe
what lab value is first affected by heparin?
ptt
first line treatment for lichen planus?
clobestasol
what skin condition is associated with gluten sensitivty and how to treat?
dermatitis herpetiformis
dapsone
what two areas of the brain light up on MRI for C jacob disease?
putanam and caudate
two causes of adrenal insufficiency to remember?
addisons
tuberculosis induced
two meds for myxedema coma
steroids and levo
what two times are prolnged with von willebrand?
treatment?
ptt
bleeding time
desmopressin
memory problems and personaility and behvaior changes, what type of dementia?
frontotemporal dementia
what is mainstay treatment for diabetic retinopathy?
laser photocoauglation
what can be used for tourettes besides guanfacne?
pimozide
what abx class causes tinnitus?
aminoglycosides
treatment for zollinger ellsion syndrome starts with?
PPI
what is second line treatment for MS flare?
plasmapharesis or acth gel
what drug is shown to slow the progression of ALS?
riluzole
what is the treatment of choice for pemhpgus vulgaris?
steroids
what procedure to consider for basal cell carcinoma of the face?
mohs
what cerebral artery supplies language center?
middle
what can metformin cause and why is this important to know if you want to do imaging?
lactic acidosis, but only in patients with low GFR, so check a creatinine or know their kidney function before doing a CT scan with contrast
what body type do men 2b people have
marfanoid
what condition do you use cosyntropin stimulation test and why>
adddison because it should trigger cortisol to be released if the adreanls are functioniung properly
what is the most common cause of secondary hypothyroidism?
pituitary adenoma, not producing tsh no no t4
test loves to use hypothyroidism to mask what conditoon?
depression
spina bifidia occulta herniation?
no externally, but can internally
Meningocele herniation?
meninges herniate externally
Meningomyelocele herniation?
both cord and meninges
what to use to treat narcolepsy with cataplexy?
pitolisant
what am i thinking if a diabetic patient all of the sudden is able to control blood sugars much better?
adrenal insuficicieny
how to best treat adrenal insufficiency?
hydro because it has glucco and hydro
triad of somatostainomas?
diabetes
gallstones
diarrhea
how do you treat insulonoma?
surgery