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Multisystem > Derm > Flashcards

Derm Flashcards

1
Q

Scale

Skin layer?

A

Epidermis

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2
Q

Change in brown, grey, black pigments

Skin layer?

A

Epidermis

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3
Q

Edema

Skin layer?

A

Dermis

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4
Q

Change in red, violacious, blue, yellow, green color

Skin layer?

A

Dermal

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5
Q

Telangectasia

Skin layer?

A

Dermis

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6
Q

Poorly demarcated borders

Skin layer?

A

Subcutaneous

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7
Q

Fixation to underlying tissue

Skin layer?

A

Subcutaneous

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8
Q

Target lesions are commonly seen in

A

SJS

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9
Q

Intetriginous

A

Seen in skin folds

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10
Q

Glaborous

A

Seen in non-hair-bearing skin

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11
Q

Excoriation

A

Scratch

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12
Q

Acral

A

Seen in head, neck, or extremities (vs truncal)

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13
Q

Difference between abscess and cyst?

A

Abscess has surrounding inflammation, cyst does not

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14
Q

Difference between erosion and ulcer?

A

Erosion is epidermis only, ulcer also includes dermis

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15
Q

Difference between erythema and purpura?

A

Erythema blanches, purpura does not

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16
Q

What are the 3 diseases that you see with arciform lesions?

A
  1. Granuloma annulare
  2. Leprosy
  3. Cutaneous T cell lymphoma
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17
Q

Which is the most common type of chronic cutaneous lupus?

A

Discoid

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18
Q

Cutaneous lupus with central scarring and possible alopecia

A

Discoid

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19
Q

What percent of patients with DLE develop SLE?

A

20%

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20
Q

Cutaneous lupus favoring trunk and extremities with little scarring

A

Subacute

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21
Q

Cutaneous lupus associated with Ro/SS-a Ab

A

Subacute

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22
Q

What percent of subacute cutaneous lupus develop SLE?

A

50%

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23
Q

Ro antibody in lupus correlates with what?

A

Photosensitivity

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24
Q

What are the two variants of subacute cutaneous lupus?

A

Psoriaform and annular

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25
Q

Cutaneous lupus associated with ANA antibodies

A

Acute

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26
Q

Cutaneous lupus associated with malar rash

A

Acute

27
Q

Progressive, proximal muscle weakness with abnormal EMG and a rash

A

Dermatomyositis

28
Q

What are Gottoron’s papules and in which disease are they seen?

A

Violaceous papules over hand knucles.

Dermatomyositis

29
Q

Red and scaly disc-shaped plaques on head and neck which progress to plaques with hyperpigmented borders and pink, atrophic, scarred centers

A

DLE

30
Q

What does generalized DLE mean and what are it’s implications?

A

Lesions that spread to trunk and arms. Increased risk for SLE.

31
Q

Polycyclic leisons in sun-exposed areas with knuckle and malar sparing.

A

SCLE

32
Q

What is Gottron’s sign and what disease is it pathognomonic for?

A

Violaceous macular erythema over any pony prominence.

Dermatomyositis

33
Q

Heliotrope sign, shawl sign, ragged nail cuticles, periungual telangectasias, tnedon streaking in hands

A

Dermatomyositis

34
Q

Mechanic’s hands, interstitial pneumonitis, increased CPK

A

Dermatomyositis

35
Q

What implications does a diagnosis of dermatositis entail?

A

Internal malignancy

36
Q

Esophageal dysfunction, arthritis, shawl sign, interstitial lung disease & mechanic’s hands

A

Dermatomyositis

37
Q

Mechanic
s hands are a sign of what?
Which antibodies are involved?

A

Pulmonary dermatomyositis

Jo-1 & PC-1 antibodies (anti-synthetase)

38
Q

Which cancer is common in patients with dermatomyositis in females? Asians?

A

F: ovarian
A: nasopharyngeal CA

39
Q

What is morphea? What dot eh lesions look life?

A

skin-only scleroderma. Hard, bound-down indurated plaques. Active borders are red-violaceous.

40
Q

Raynaud’s, Sclerodactyly, Esophageal dymotility, over face, cheast, extremities, anti-centromere

A

CREST (limited cutaneous systemic sclerosis)

41
Q

Beak-like nose, digital pitted scars, salt & pepper changes, antitopoisomerase-1 (Scl-70)

A

Diffuse cutaneous systemic sclerosis

42
Q

Hyperpigmented, slightly atrophic plaques mainly seen over shins

A

Diabetic dermopathy

43
Q

Erythematous, indurated plaques that progress to form yellow atrophic plaques with telangectasias on anterolateral distal legs. May ulcerate

A

Necrobiosis lipodica diabeticorum

44
Q

Ring-shapes papules/plaques in distal extremmities, associated with diabetes

A

Granuloma annulare

45
Q

Superficial erythema with honey-colored crust

A

Impetigo

46
Q

LArge, deep staph infection with pustules and crust

A

Pyoderma

47
Q

Diffuse dermal infection with redness and swelling

A

Cellulitis

48
Q

Pre-tibial myxemdema, pseudoclubbing, soft tissue swelling of hands & feet

A

Hyperthyroidism

49
Q

Will correcting thyroid function improve skin disease?

A

Not necessarily

50
Q

Thick lips, large tongue, loss of lateral 1/3 eyebrows

A

Hypothyroidism

51
Q

Half of patients with vitiligo will develop which disease?

A

Hypothyroidism

52
Q

What is the pathophysiology of vitiligo?

A

Autoimmine destrcution of melanocytes, favoring face, hands. Causes hypopigmented macules.

53
Q

Tender, erythematous nodules over bilateral shin. May have fever, arthalgias

A

Erythema nodosum

54
Q

Which conditions are associated with erythema nodosum?

A

UC, Chron’s, Sarcoidosis (Lofgren), Behcet’s, strep infections, drug allergies, pregnancy, malignancy

55
Q

Ulcer with violacious, undertermined borner and purulent base. Usually lower extremities. Koebnerization.

A

Pyoderma gangrenosum

56
Q

Pyoderma gangrenosum is associated with which conditions?

A

UC, Chron’s, RA, monoclonal IgA gammaopathy, hematologic malignancy

57
Q

Arthitis, uveitis, erythema nodoum

A

Lofgren’s

58
Q

Red-purple tender mamillated “mountain range” lesions pn arms, neck, face. May have fever, myalgias, leukocytosis. May be preceded by URI or flu.

A

Sweet’s syndrome

59
Q

What conditions are associated with Sweet’s?

A

AML, solid tumors, strep, gCSF. IBD, pregnancy

60
Q

Immune complex deposition around blood vessels causing PMN infiltration & palpable purpura.

A

Leukocytoclastic vasculitis

61
Q

Leukocytoclastic vasculitis is associated with which conditions?

A

Beta lactams, NSAIDS, antibiotics, strep, TB, flu, malignancy

62
Q

Which conditions are asspociated with cryoglobulinemic vasculitis?

A

Hep C (arthitis & glomerulonephritis), RA, malignancy

63
Q

What are the classic symptoms of HSP?

A

IgA leukocytoclastic vasculitis, arthritis, abdominal pain, nephritis

64
Q

What si the most common cause of HSP?

A

beta lactams

Multisystem (5 decks)

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