Derm Flashcards
How to sample wet/greasy skin for microbiology
Impression smear or indirect (with swab)
How to sample dry skin for microbiology
stained acetate tape strip
Staining protocol for
Impression smear
Acetate samples
Waxy ear smears
IS = ABC
AS = BC (no fixative)
WES: C (Only methylene blue)
How to view cytology V parasites on microscope
Cytology = 4-100X with oil
Parasites = 4-10X
Name the four cutaneous reactions patterns of cats
Head and neck pruritus (often fleas)
Self induced alopecia (Bilateral and symmetrical)
Eosinophilic granuloma complex (can be ulcerated)
Miliary dermatitis (on the dorsal)
Common reasons to see the 4 reaction patterns
Common reasons are flea, food and environmental atopy.
What is the importance of knowing if the purities or the lesions came first
Allergic disease = pruritus precedes lesions
Immunosuppression or endocrinopathies = no pruritus until secondary pyoderma lesions develops
where are cats v dogs effeceted with Flea bite hypersensitivity
Dogs = Caudal half of the body (tail base, thighs, inguinal area) and dorsum
Cats = 4 rection patterns
Common flea treatments
- Imidacloprid (A + L)
- Selamectin (A + L)
- Fipronil (A)
- Isoxazolines (A)
Ease of treating fleas V lice
Fleas = can’t kill pupae and also have to treat part of lice cycle in enviroment
Live = easy as whole life is on host
Distinctive signs of sarcoptic mange (Sarcoptes scabiei var. canis)
Intense pruritis
Papules and crusts especially on pinnal margins
80% show pinnal pedal reflex!!!!
Difference in appearance of sarcoptes V Cheyletiella
S = round with 8 short legs (deep scrape)
C = hear shaped, 8 long legs, curved mouth parts (superirical scrape_
Signs of Cheyletiellosis
- Pruritus and scale, esp dorsal trunk
Signs and appearance of Otodectes
- Ear irritation, head shaking
- Excessive ear wax
- Occasional irritation of face, body
idk why they’re always in pairs and shaggin
How to perform a deep skin scrape
Scrape into liquid paraffin and put a cover slip on
Treatments for arachnids (mites)
Sarcoptes = isoxazolines (Sarolaner, afoxolaner, fluralaner) are licensed. Also selamectin, moxidectin can be used
Cheyletiella = nothing licensed but use the same as sarcoptes
.
Feline demodex = No licensed products
Canine demodex = isoxazolines
Otodectes = systemic isoxazolines, selemectin or moxidectin
Products to treat the environment for fleas
Pymethrin and IGR
4 presentations of surface pyoderma
- Intertrigo (skin fold)
- Acute moist dermatitis, pyotraumatic dermatitis (‘hot spots’)
- Bacterial overgrowth syndrome
- Mucocutaneous pyoderma
Top differential fr patch alopecia
Pyoderma
also see pustules and pruritus
what are hotspots
- Acute lesion from self-trauma
- Triggered by irritant (flea bite, classically)
- Very rapid development of bacterial overgrowth
common bacteria implicated in surface pyoderma
Staphs - especially S. pseudintermedius
Difference in surface V superficial pyoderma on cytology
- Surface = bacterial overgrowth, no inflamm
- Superficial = degenerative neutrophils, high numbers of cocci
How does superficial pyoderma present
- Impetigo (often due to immunosupression or immaturity)
- Exfoliative superficial pyoderma (erythematous rings with central alopecia)
- Bacterial folliculitis
all = see patchy alopecia
Short coated = moth eaten, patchy
Heavy coated = thinning undercoat
How to treat surface and superficial pyoderma
Topical ONLY (unless superficial really bad)
- CHEX washes (+ moisturiser)
- Steroids in surface, try avoid or only a short course in superficial as don’t want to dampen immune response
What factors predispose to malassezia
- Skin folds, pendulous lips, hairy feet) warm lipid-rich environment
- Underlying disease (allergies, endocrinopathies) Alter skin barrier - Breed – e.g. Bassets + Devon Rex cats with high normal mucosal populations
Treatment for malassezia pyoderma
- Miconazole/chlorhexidine
- Chlorhexidine shampoo or foam or wipes
- Drying so add moisturiser
Other considerations when treating surface, superficial and malassezia pyoderma
Both infections are secondary problems – need to address underlying disease for long term control
- Compromise of cutaneous defences, e.g.
§ Mechanical damage to skin
§ Defects in skin barrier function
§ Changes to innate/acquired immunity - Increased microbial adherence (e.g. with canine atopic dermatitis (CAD)
- Changes to skin microclimate
What to parasiticides are topical and therefore not good for swimmers
Neanicitinoids (Imaclopramid (Advocate)) and Fiprinol
Names of isoxazalines and what they cane be used for and precaution
Fluranaler (Bravecto) Sarolaner (Stronghold) Afoxolaner
Literally everything: fleas, lice, ALL mites, ticks
care re seizures
Cautions to take if using macrocyclic lactones (selemectin, moxidectin) or Pyrethroids (On environment for fleas)
ML = can be toxic to collies
P = toxic to cats
Age of onset of CADs (e and F)
Environmental = 6 months to 1 year
food = any age but 1/3 under a year
Signs of CADs (E and F)
Clinically indistinguishable
- Pruritis
- Can present as pyoderma that responds to therapy
- Face, ears, ventral abdomen, perineum, Carpi/tarsi, feet
- Uncomplicated case: Erythema, Self-induced alopecia, excoriations, Primary papular eruption
- With chronicity: Lichenification, hyperpigmentation
Difference in lesions in CAD cases compared to sarcoptes and fleas
CAD = unaffected ear margins (sarcoptes), and unaffected dorsal region (fleas)
2 tests to identify environmental allergens for avoidance
Serological testing (Ensure CDD blockers used)
Intradermal skin testing to look for a reaction
How to diagnose food atopic dermatitis
Exclusion diet trial (for minimum of 8 weeks)
Hydrolysed, limited antigen (novel), or home cooked (novel)
Hydrolysed best BUT ensure fully hydrolysed and avoid chicken hydrolyse diets
- If pruritis resolves, rechallenge with old diet to confirm. Treatment = feed exclusion diet now.
Presentation of feline atopic dermatitis
- FASS, FFA and flea allergic dermatitis (FAD) can cause any/all cutaneous reaction patterns
What is FASS and FFA
Feline atopic skin syndrome (FASS)
- Inflammatory/pruritic skin syndrome, likely associated with IgE to environmental allergens
- Usually young adult – 6mo-5y onset
Feline food allergy (FFA)
- Can occur at any age (3mo+) but 30% cats <1yo
name the 4 drugs commonly used to control inflammation and pruritus
prenisalone (steroid)
Oclacitinib (Apoquel) (JAK inhibitor)
Lokivetmab (Cytopoint) (Pruritus only, IL-31 inhibitor)
Ciclopsorin (Atopica) (T-cell suppressor)
Pros and cons of prednisolone
Pros: Cheap, effective, easy, anti pruritic and anti-inflammatory
Cons: Lots of side effects, need lots of monitoring, immunosupression
Pros and cons of Oclacitinib
(Apoquel)
Pros: quick to act (24 hours), for allergic dermatitis ONLY
Cons: expensive. Can’t use in dogs under 1 year, alongside preds or ciclosporin, causes immunosupression
Pros and cons of Lokivetmab
(Cytopoint)
Pros: Quick to act (24 hours), only monthly dosing, safe and more specific (acts on IL-31)
Cons: Not anti-inflammatory, expensive
What must be done before giving cats ciclosporin
How long does it take to work?
Supresses T cells so test for FeLV/FIV/toxoplasmosis
Slow (1-2 months)
oral dosing every 24 hours
Downside of using immunotherapy
Takes a year to take effect and have to use other treatments in this time
Cytological appearance of an ulcer
Macrophages present, blood cells too
full thickness wound to dermis
(erosion is only superficial)
Tx for herpes virus
Support; feeding tube, anti-virals
Systemic famciclovir in severe cases
Appetite stimulants e.g. mirtazapine
Calicli = add lysine too
What feline viruses can present with cutenaous ulcers? and where?
Herpes virus: lesions make a mask. eyelids, muzzle, nose
Calicli virus: ulcers on mucous membranes, lips and nose
Signlament and signs of feline cowpox
Signalment: Male hunting in late summer
Signs: Onset of a single crusted ulcerated lesion followed by smaller lesions (satellites)
signs start at head, sometimes for feet