Depression W8 L15 412 Flashcards

0
Q

Depression: Symptom versus Syndrome versus Disorder

A

 Symptom
 Feeling or emotion of sadness
 Very common (40% at any given time)

 Syndrome
 Cluster of common symptoms
 “Negative affect” and dimensional view of depression

 Disorder / Diagnosis
 Syndrome with minimum duration
 Syndrome with required impairment

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1
Q

Core Features of depression?

A

 At least one of the following, most of the day, nearly every day, for two weeks:

Dysphoria
 prolonged sadness
some sadness normal, even needed in life, but prolonged and distressing no good. Nearly everyday for two weeks but for children …

 Irritability
 excessive sensitivity, hostility, and moodiness
 unique to children and adolescents

 Anhedonia
 loss of pleasure or interest in previously enjoyable activities

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2
Q

Major Depressive Disorder

A

 5 Symptoms Total needed (9 possible)
 During the same two week period

 At least one of:
 Depressed mood, most of the day, nearly every day OR irritability (children
and adolescents only), most of the day, nearly every day
 Anhedonia (loss of interest or pleasure), most of the day, nearly every day

 Significant weight loss or gain or decrease or increase in appetite nearly every
day (In children, consider failure to make expected weight gains)

 Insomnia or hypersomnia nearly every day

 Psychomotor agitation or retardation nearly every day (observable by others), extreme sluggishness walking through molasses.

 Fatigue or loss of energy nearly every day

 Feelings or worthlessness or excessive or inappropriate guilt nearly every day

 Diminished ability to think or concentrate, or indecisiveness, nearly every day,

 Recurrent thoughts of death (not just fear of dying), recurrent suicidal ideation without a specific plan, or a suicide attempt or a specific plan for committing suicide

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3
Q

Persistent Depressive Disorder (Dysthymia)

A

 Depressed or irritable mood for most of the day, more days than not, as indicated by either subjective account or by observation by others, for at least 1 year
(In adults, mood must be depressed and must last for 2 years)

 Presence while depressed, of two (or more) of the following:
 Poor appetite or overeating
 Insomnia or hypersomnia
 Low energy or fatigue
 Low self-esteem
 Poor concentration or difficulty making decisions
 Feelings of hopelessness
 During the 1 year period, the person has never been without the symptoms for more than 2 months at a time

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4
Q

Persistent Depressive Disorder (Dysthymia)

Specification / co-occurrences

A

 Pure dysthymic syndrome
 Full criteria for major depression have not been met in the
preceding year

 With persistent major depressive episodes
 Full criteria for a major depressive episode have been met
throughout the preceding year

 With intermittent major depressive episodes
 Person has met criteria for one or more major depressive episodes during the preceding year

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5
Q

Depression Diagnoses
 Categorical (same in kind) versus dimensional

A

 Recall that one disadvantage of a categorical approach is that there are a group of individuals who will not quite make the cutoff

 Many children and adolescents will have subclinical depression
They will not quite make diagnostic criteria, but they have a significant number of symptoms
Show significant impairment (e.g., academic, social)
At greater risk for going on to develop depression as well as other disorders and difficulties (e.g., substance use)

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6
Q

Epidemiology of Major Depressive Disorder (MDD)

A

Prevalence
 1% of preschool children
 2% of schoolchildren
 Note that these could be underestimates
 8% of adolescents lifetime

 Cultural and contextual differences
 Higher symptoms in minority youths
 Likely reflects SES differences

 Life stressors and daily hassles important
More hassles for children in low-SES environments

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7
Q

Epidemiology
 Gender differences

A

 NO gender differences in childhood – between 6 and 11 years
of age, boys and girls are equally likely to be depressed
 Between ages 13 and 15, ratio becomes 2 girls:1 boy, driven by increase in girls
This maintains through adulthood

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8
Q

Gender Differences in Depression

A

 A lot of research has been done to try and understand why adolescent girls (and women) are so much more likely to experience depression
 Important to note that no one variable explains the difference
 Likely a combination of factors:

 Higher experience of stressors and trauma

 Biological
 Dysregulated HPA axis – overly reactive to stress

Coping styles

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9
Q

Gender Differences in Depression
Higher experience of stressors and trauma

A

 Robust link between stress and depression
 Girls/women far more likely to be sexually assaulted
 Women are more likely to live in lower-SES conditions
 Biological

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10
Q

Gender differences in depression

Coping styles

A

Rumination
 Thinking about a problem constantly, but never moving to active problem-solving
 In the context of depression: Why do I feel like this? Why is this happening to me? What’s going to happen to me? I’ll never get better. I’ll never feel good again. This is so unfair.

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11
Q

Course and Prognosis of depression

A

 For a long time, people thought that children could
not be depressed
 Within the psychoanalytic tradition, children lacked sufficient superego development to be depressed. WRONG!

 Even very young children can be depressed
May be hard for adults to see it

 Many of the symptoms of depression are internal
Sadness, shame, guilt, feelings of worthless

 Behavioral profile is hetergeneous, withdrawal less assertive or conversely could be more aggressive,

 Avoidance, reduced assertiveness, but some children are more aggressive and hostile

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12
Q

Depression in Preschoolers?

A

 Was originally thought that preschoolers would only show “masked” symptoms of depression

 E.g., aggression, somatic symptoms
 Outward manifestations of an underlying depressed mood
 Would not show the “typical” symptoms of depression

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13
Q

Luby et al. 2003, depression of preschoolers,
 Luby et al. (2003) tested this hypothesis
 Parents of preschoolers completed a psychiatric
interview
 Ended up with three groups of children  MDD (59 children)
 ODD/ADHD  No disorder

A

Procedure:
Psychiatric interview asked about typical symptoms
Also asked about “masked symptoms”

Results:
Typical symptoms often showed high specificity/sensitivity
Absence Of symptôme jeans nô disorder.
 Specificity is the likelihood that child without the disorder will not have the symptom
 Anhedonia
 Presence of anhedonia rules in the , inhérent in the discorder, specificity to the disorder.
Unlike sensitivity, where if you do not have sadness are not depressed, can have sadness without being depressed.

Do see some masked symptoms, but also see specificity of classic depression symptoms, like sadness or anhedonic.

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14
Q

Depression in Preschoolers sensitivity

A

 Some typical symptoms also show high sensitivity
 Sensitivity is the likelihood that a child with the disorder will have the symptom
 Sadness/grouchiness
 Absence of symptom rules out the disorder

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15
Q

Preschoolers
 Note that for preschoolers, some modifications to DSM criteria need to be made so?

A

Depression in
 Sadness and unhappiness versus sadness and depression
 “Activities and play” versus “work and school”
 Themes of suicide and death in play
 Possible that 2-week duration used for older children and adults may not be applicable to young children

16
Q

What is the Course of Depression?

A

 Course
 Untreated MDD lasts 8-12 months
 Untreated dysthmic disorder (DD) lasts 2-5 years
 Residual symptoms frequently present at end of episode
 Residual symptoms strong risk factor for recurrence

17
Q

Course of Depression
MDD recurrence

A

 Preschoolers with depression are 4 times more likely than those without depression to meet criteria for major depressive disorder 2 years later
 For children and adolescences who experience a major depressive episode, recurrence is common:
25% within 1 year
40% within 2 years
70% within 5 years

30% develop Bipolar Disorder (“BP switch”)

 Most adults with MDD date the onset of first episode to adolescence teen

18
Q

Course of Depression: Kindling hypothesis is?

A

 First episodes frequently follow significant life stress
 Biological changes that make you more reactive to stress in the future
 Thus, later episodes may require less stress to begin

19
Q

What is the Prognosis for depression

A

 Depression recurs
 Children and adolescents who have a depressive episode are
more likely to have depressive episodes as adults
 Earlier it starts, the worse the prognosis is
 More severe, chronic course, greater suicidality
 Is depression in childhood/adolescence associated with likelihood of other disorders in adulthood?
 Heterotypic continuity: other disorder assocItion in adulthood?
 Is depression in childhood/adolescence associated with other problems in adulthood?

20
Q

Prognosis Study of a longitudinal cohort in New Zealand
 Followed them from birth
 Met DSM-criteria for Major Depression at 15 to 16 years of age
 Examined psychopathology, educational, and social outcomes in early adulthood

A

3.5x homotypic continuity.
More likely to have anxiety disorder in adulthood!
None of other things sig. Though.

Looking for effect of depression, controlling for a lot, so conservative!
Note also that these analyses took into account co- morbid conditions (e.g., conduct disorder)

21
Q

Co morbid conditions usual come

A

First

22
Q

Co-morbidity
 For Major Depressive Disorder

A

 Anxiety
 wDysthymia, conduct problems, ADHD, substance use  In general, co-morbid conditions come first
 Anxiety, conduct disorder, ADHD
 Again, these usual precede dysthmia

23
Q

Co-morbidity

wDysthymia

A

, For Dysthmia:  MDD
 Anxiety, conduct disorder, ADHD
 Again, these usual precede dysthmia

24
Q

Ffected on Cognitive Functioning for those who are depressed

A

 IQs in the normal range
 Children with depression perform more poorly in
school
 Symptoms of depression:
 Poor concentration
 Low energy
 Fatigue

25
Q

Explain Suicidality in depressed

A

Suicidality
 SUICIDE: taking ones own life
 SUICIDALITY: also includes attempts, intent,
ideation

 Suicide is the second leading cause of death among Canadian children and adolescents (ages 10 to 19 years)

 In 2008, 20.4% of all deaths for youth aged 10 to 19 were due to suicide, compared to 1.5% of all deaths in Canada

26
Q

Two strongest predictors for suicidal behavior are:

A

 Mood disorder,
being a young female

 60% of children and adolescents with major depression report suicidal thoughts
 Approximately 30% will attempt suicide

27
Q

Girls are more likely to attempt suicide; however, they often use?
And Boys are more likely to use?

A

less lethal means (drugs, wrist cutting)

firearms, and as a result, are more likely to complete suicides

 Among Canadian children and adolescents, most common method is suffocation

 Accidental deaths by “choking game” may be misclassified

28
Q

Research with adults on judgement of lethality (Brown et al., 2004, JCCP):

A

 No relationship between person’s perception of lethality and actual lethality

 This does not very by gender

 No association between suicidal intent and lethality (also see Beck et al. 1975)

 Means chosen do not tell you about person’s intent to die

29
Q

What is Non-Suicidal Self Injury (NSSI)

Prevalence?

A

 Deliberate, destruction of your own body tissue in the absence of intent to die
 People are not good at judging lethality
 Cutting, burning, biting

 17% of adolescents report engaging in one of these
behaviors
 Associated with a number of psychological disorders, including depression and anxiety

30
Q

NSSI
 Functional approach to NSSI
 (risky painful) Behavior is reinforced by

A

intra- or interpersonal
 Way to regulate negative mood

 Intrapersonal negative reinforcement
 Reduces or stops aversive thoughts and feelings

 Intrapersonal positive reinforcement
 Generates desired feelings

 Way to obtain desired consequences in the environment
 Interpersonal positive reinforcement
 Care and attention

 Interpersonal negative reinforcement
 Less responsibility

Solution not to ignore, instead shift to positive behavior reinforcement.