Depression Flashcards

1
Q
Major Depressive Disorder
Dysthymic Disorder
Premenstrual Dysphoric Disorder
Substance-Induced Depressive Disorder
Depressive Disorder Associated with Another Med. Cond.
A

Types of Depressive Disorders

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2
Q

characterized by depressed mood
Loss of interest or pleasure in usual activities
Symptoms have been present for at least 2 weeks
No hx of manic behavior
Can’t be attributed to use of substances or another medical condition

A

Major Depressive Disorder (MDD)

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3
Q
Sad or "down in the dumps"
No evidence of psychotic symptoms
Essential feature is a chronically depressed mood for 
-most of the day
-more days than not
-at least 2 years
A

Dysthymic Disorder

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4
Q
Depressed mood
Anxiety
Mood swings
Decreased interest in activities
*Symptoms begin during week prior to menses, start to improve within a few days after the onset of menses, and become minimal or absent in the week post-menses
-last 2 weeks (day 15-28 in cycle)
PMDD Sarafem 
Generic prozac ( fluoxetine); with anxiety
A

Premenstrual Dysphoric Disorder (PMDD)

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5
Q

Considered to be the direct result of physiological effects of a substance
-makes them feel good; release of neurotransmitters in the brain
Self medicating

A

Substance-Induced Depressive Disorder

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6
Q

Attributable to the direct physiological effects of a general medical condition
-appetite and sleep (increase or decrease)

A

Depressive Disorder Assoc with Another medical condition

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7
Q

Biological theories

  • Genetics;
  • Biochemical
  • Neuroendocrine disturbances
  • Physiological influences
  • Psychosocial theories
A

Predisposing factors

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8
Q

Genetics; hereditary factor maybe involved
tendencies to become depressed runs in families.
Can beat this
*Once a major depressive disorder happens likely to have again.

A

Biological theory of Depression

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9
Q

Deficiency of norepinephrine, serotonin, and dopamine has been implicated
Excessive cholinergic transmission may also be a factor
-Body under stress; expends neurotransmitters

A

Biochemical Factors of depression

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10
Q

possible failure within the hypothalamic-pituitary-adrenocortical axis
-stressful anxious things happen to them
Possible diminished release of thyroid-stimulating hormone

A

Neuroendocrine disturbances

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11
Q

Cognitive theory:
Views primary disturbance in depression as cognitive rather than affective

3 cognitive distortions that serve as the basis for depression:

  • Negative expectations of the environment
  • Negative expectations of the self
  • Negative expectations of the future

before neurotransmitters where discovered factors in depression

A

Psychosocial theories
Negative triad
(NTK!!)

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12
Q

Less than 3; feeding problems, tantrums, lack of playfulness and emotional expressiveness

  • Age 3 to 5; accident proneness, phobias, excessive self-reproach (thinking terrible, nobody likes me)
  • Age 6 to 8; physical complaints, aggressive behavior, clinging behavior (clinging not typical);
  • Age 9 to 12; morbid thoughts and excessive worrying; wearing all black, anxious

Possibly percipitated by a loss
Need focus therapy: alleviate symptoms and strengthen coping skills; aggression management

Parental and family therapy
Punishment doesn’t work, esp ODD, work to earn something

A

Childhood Depression Symptoms

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13
Q

Anger, aggressiveness, running away, delinquency, social withdrawal, sexual acting out, substance abuse, restlessness, apathy

Best clue that differentiates depression from normal stormy adolescent behavior
-A visible manifestation of behavioral change that lasts for several weeks
-Most common precipitant to adolescent suicide
-Perception of abandonment by parents or close peer relationships.
Disconnect between suicidal threats and reality (no coming back)

A

Adolescence symptoms of depression

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14
Q

Bereavement overload-so many loses
High percentage of suicides among elderly
symptoms of depression often confused with symptoms of neurocognitive disorder

Treatment:
Antidepressant medication
Electroconvulsive therapy
Psychosocial therapies

A

Senescence

deterioration of age

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15
Q

May last for a few weeks to several months
Associated with hormonal changes, tryptophan metabolism, or cell alterations

Treatments:
Antideppresants and psychosocial therapies
Symptoms:
Fatigue
Irritability
Loss of appetite
Sleep disturbances
Loss of libido
Concern about inability to care for infant
A

Postpartum Depression

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16
Q

also called affect.
pervasive and sustained emotion that may have a major influence on a person’s perception of the world.
-depression, joy elation, anger and anxiety
-emotional reaction assoc. with an experience

A

Mood

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17
Q

an alteration in mood that is expressed by feelings of sadness, dispair, and pessimism. Loss of interest in unusual activities and somatic symptoms maybe evident.
-changes in appetite and sleep patterns are common.

“evil spirit”; old testament-depression sent to God to torment

A

Depression

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18
Q

was caused by an excess of black bile, heavily toxic substance prod. from the spleen or intestine, affecting brain hypocampus

A

melancholia

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19
Q

2 prevalent periods; spring and fall. pattern parallels suicide.

  • temp & barometric pressure changes to human mental instability
  • sociodemographic variables,
  • serotonergic function involved in depression and suicide
A

Seasonality Depression

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20
Q

excessive estrogen to progesteron ratio implicated

A

hormonal disturbances

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21
Q

decrease in B1 *thiamine and B6 *pyridoxine, B12, niacin, Vit C, iron, folic acid, zinc, Ca, K+, can produce depression

A

nutritional deficiences

22
Q

behaviors such as excessive crying, anorexia, withdrawal, psychomotor retardation, stupor, and generalized impairment in the normal growth and development.

A

Object loss theory

23
Q

focuses on helping the ind. to alter mood by changing the way he or she thinks.
-ind. is taught to control neg. thoughts, distortions that leads to pessimism, lethargy, procrastination, and low self-esteem

A

cognitive therapy

24
Q

depression; not functional

A

transient

25
Q

uncomplicated grieving

A

mild depression

26
Q

problematic disturbance (dysthymia)

A

moderate depression

27
Q

intensified syptoms described in moderate depression

A

severe depression

28
Q

1st go to medication for depression

  • Citalopram (Celexa)
  • Escitalopram (Lexapro)
  • Fluoxetine (Prozac, Sarafem)
  • Fluvoxamine (Luvox)
  • Paroxetine (Paxil)
  • Sertraline (Zoloft)
  • Vilazodone (Vilbryd); also acts aas a partial serotonergic agonist
A

SSRI’s Selective serotonin reuptake Inhibitors

29
Q

Norepinepherin;
Serotonin
Dopamine
*It is important to be able to connect symptoms present in the depression in order to understand which neurotransmitters are involved.

A

Neurotransmitters involved with Depression

30
Q

important for executive functions (memory, reasoning, problem solving, planning)

A

Norepinepherin

31
Q

mood, appetite, libido and cognition

A

Serotonin

32
Q

motivation, concentration, and pleasure

A

Dopamine

33
Q

Antidepressants half life, overall potency, and strength of dose can influence how fast and antidepressant works, chemistry and how healthy a person is. Down regulation to completely finish.

A

Up to 6 weeks for an antidepressant to work

34
Q

taken back to original neuron; an increase in cellular component; increasing the response of a stimulus

A

Upregulation

35
Q

negative feedback mechanism; process by which a cell decreases quality of a cellular component, ie. RNA, protein, # of receptors in a molecule

A

downregulation

36
Q

the absorption by a presynaptic nerve ending of a neurotransmitter that it has secreted.

A

Reuptake

37
Q

Ease depression by affecting naturally occuring chemical messengers (neurotransmitters)
-block reabsorption (reuptake) of the neurotransmitter, serotonin in the brain.
~changing the balance of serotonin seems to help brain cells send and receive chemical messages; increasing mood

A

Action of SSRI’s in the brain.

38
Q

most potentially life-threatening adverse effects of MAOI’s

A

HTN Crisis

39
Q

presynaptic reuptake of the neurotransmitters or block receptors at nerve ending

A

mechanism by which antidepressant meds achieve their desired effects

40
Q
  • suicidal thoughts, tremors, cardiac arrhythmias, sexual dysfunction and hypertension (block of norepinephrine)
  • GI disturbance, increase agitiation, and sexual dysfunction (serotonin)
  • psychomotor activation (dopamine)
  • dry mouth, blurred vision, constipation and urinary retention (acetylcholine; tricyclic antidepressant)
  • sedation, weight gain, hypotension (histamine)

*Suicidal to happy as ever-going to kill themselves; Key indicator to having a plan; black box warning

A

Side effects of antidepressants

Nurse to look out for

41
Q

Foods high in tyramine; Na-perservatives; beef jerky, olives, cheese, wine,

headache, palpitations, nausea/vomiting, sweating; topical corticosteriods to prevent side effects

Ingestion of such substances while on an MAOI therapy could result in life threatening hypertensive crisis
-14 day interval recommended before starting an MAOI
All other antidepressants
Sympathomimetics
Stimulants
Antihypertensives
Meperidine and opioid narcotics
Antiparkinsonian agents (Levodopa)
A

avoid maoi therapy

42
Q

Aged cheeses (cheddar, swiss, camembert, blue cheese, parmesan, romano, brie)
raisins, fava beans, flat italian beans, chinese pea pods,
Red wines (chianti, burgundy, cabernet sauvignon)
smoked and processed meats
Caviar, pickled herring, corned beef, chix or beef liver
Soy sauce, brewer’s yeast, meat tenderizer (MSG)

A

High tyramine Content; Avoid when on a MAOI

43
Q

Gouda cheese, processed American cheese, mozz, yougurt, sour cream, avocados, bananas
Beer, white wine, coffee, colas, tea, hot choc
Meat extracts, bouillon cubes
Chocolate

A

Moderate Tyramine Content; Avoid when on a MAOI

44
Q

Pasteurized cheeses, cream cheese, cottage cheese, ricotta
Figs
Distilled spirits (in moderation)

A

Low Tyramine Content; Avoid when on a MAOI

45
Q
Amitripyline
Amoxapine
Clomipramine (Anafranil)
Desipramine (Norpramin)
Doxepin
Imipramine (Tofranil)
Nortriptyline (Aventyl) (Pamelor)
Protriptyline (Vivactil)
Trimipramine (Surmontil)
A

Tricyclics antidepressant meds

acetylcholines

46
Q

Isocarboxazid (Marplan)
Phenelzine (Nardil)
Tranylcypromine (Parnate)
Selegiline Transdermal System (Emsam)

A

Monoamine Oxidase Inhibitors (MAOI’s)

47
Q
Bupropion (Wellbutrin)
Maprotiline
Mirtazapine (Remeron)
Nefazodone
Trazodone
A

Heterocyclic

48
Q

Desvenlafaxine (Pristiq)
Duloxetine (Cymbalta)
Venlafaxine (Effexor)

A

SNRI’s Serotonin-norepinephrine Reuptake Inhibitor

49
Q

Olanzapine and fluoxetine (Sumbyax)

Chlordiazepoxide & amitriptyline (Etrafon)

A

Psychotherapeutic Combinations

50
Q

Don’t mix with MAOI’s
decreased effects of Levodopa & guanethidine
Increase risk of seizures with concomitant use of maprotiline and phenothiazines

A

TCA interactions

51
Q
blurred vision
constipation
urinary retention
orthostatic hypotension
reduction of seizure threshold
tachycardia, arrhythmias
photosensitivity
weight gain
A

Side effects of Tricyclics and Heterocyclics

52
Q
Insomnia; agitation
headache
weightloss
sexual dysfunction
serotonin syndrome; change in mental status, restlessness, muscle rigidity
A

side effects with SSRI’s and SNRI’s