Dementia Flashcards
Age is a major risk factor for _
Alzheimer’s
Normal aging is associated with mild changes in cognition. True or false. How do health co-morbidities affect aging?
True
Make aging less “graceful”
For the term dementia to be used, what criteria must be met?
Cognitive impairments must affect daily life
Depression is associated with dementia. true or false
True
Dementia is reversible. True or false?
True, but depends on the cause
The normal form of AD has high or low heritability?
Low. Early onset is higher
A major difference between neurosyphillis and AD is _
NS presents with fever
An age related, irreversible, gradual decline in thinking associated with breakdown of brain cells described _
AD
Under what circumstances would an invasive proceedure (needle biopsy) be used to test for dementia?
Fast progressive (CJ prion disease)
What are neurofibrilary tangles? Where are the found? What other diseases are they found in?
Tangle of phospho-Tau found within cytoplasm`
Normal aging, Downs Syndrome
What is the effect of neurofibrillary tangles?
Kill cells, leave ghost tangle
What are neuritic plaques?
Extracellular areas of tissue degeneration, filled with amyloid
Tangles and Plaques affect what areas of the brain (3)?
Cortex
Amygdala
Nucleus Basalis of Meynert
NFTs are most likely to be found in _
Anterior parahippocampal gyrus (entorhinal cortex)
Frontal assoc. cortex
Inferior parietal cortex
Lateral temporal lobe
Amyloid plaques are most likely to be found _
Through out cortex
In parietal and temporal lobe
