Delirium

Question 1

• disturbance of consciousness (reduced clarity of awareness of the environment with reduced ability to focus, sustain or shift attention)
• a change in cognition (memory deficit, disorientation language disturbance) or development of perceptual disturbance

Answer 1

delirium

Question 2

the disturbance develops over a ______ period of time (hours to a few days) and tends to fluctuate in ________

Answer 2

short, severity

Question 3

the disturbances are not better explained by another __________ disorder and don’t occur in the context of a reduced level of _______

Answer 3

neurocognitive, arousal

Question 4

when oxygen delivery to the brain tissue falls

Answer 4

anoxia

Question 5

in anoxia ______ floods cells and ______ flows out of cells

Answer 5

sodium and calcium, potassium

Question 6

calcium influx accelerates tyrosine hydroxylase, increasing _______ production

Answer 6

dopamine

Question 7

calcium influx stimulates ______ release

Answer 7

neurotransmitter

Question 8

decreased oxygen results in breakdown of ATP dependent transporters thus decreasing ____________

Answer 8

neurotransmitter reuptake

Question 9

decreased oxygen decreases ___________ activity, therefore can’t convert dopamine to noepinephrine

Answer 9

dopamine-beta-hydroxylase

Question 10

hypoxic condition shifts dopamine metabolism to more toxic oxidative paths generating _______

Answer 10

cytotoxic quinones (6-OHDA)

Question 11

psychopharmacology treatment?

Answer 11

dopamine antagonists

Question 12

what dopamine antagonist is the most pure antipsychotic?

Answer 12

haloperidol, D2 target