2.1 Cellular Neuropathy Flashcards
- caused by anoxia, ischemia, hypoglycemia
- cell atrophy, nuclear pyknosis, and loss of Nissl and nucleolus
- loss of H, leaves eosinophilic red appearance
acute neuronal injury
atrophy of neurons leads to retraction of cell body and nuclear ______
pyknosis
injury to axon leads to cell body swelling and central __________ due to Nissl displacement
chromatolysis
degeneration of nerve fibers distal to injury is called _________ degeneration
Wallerian
atrophy of nerve cells due to loss of afferent input
transsynaptic degeneration
supportive cells responsible for inflammation, repair, and fluid balance
glia
astrocytes, oligodendrocytes, and ependymal cells derived from _________
neuroectoderm
microglia derived from _______
mesoderm
- small oval nuclei
- supportive stroma of CNS
- metabolic support, detoxifiers
- contain GFAP
astrocytes
foot processes of _________ help as a barrier in the BBB
astrocytes
astrocytosis is indicated by _____ or _____ antibodies
gliosis, GFAP
- astrocytic process inclusions
- composed of heat shock proteins
- seen in chronic gliosis, pilocytic astrocytomas, Alexander’s
rosenthal fibers
5-50 micron structures associated with astrocytic foot processes
- HSP, ubiquitin
- degenerative change, increase with age
corpora amylacea
- make and maintain myelin
- injury leads to loss of myelin or abnormal myelin
- inclusions: infections, neurodegenerative
oligodendrocytes
____ virus infects oligodendrocytes
JC
