definitions B1

Question 1

define bioavailability

Answer 1

the rate n extent by which a drug reaches systemic circulation in a unchanged form

Question 2

biotransformation

Answer 2

enzyme catalyzed biochemical transformation of drugs within the living organism

Question 2

receptor

Answer 2

any cellular macromolecule located on /within cell to which a drug can bind n initiate its effect

Question 3

ligand

Answer 3

any molecule that can interact with a receptor

Question 4

affinity

Answer 4

ability of drug to bind to the receptor

Question 5

intrinsic activity

Answer 5

ability of drug to activate n induce a conformational change in the receptor aft occupying the receptor

Question 6

agonist

Answer 6

chemicals that interact with a receptor n initiate a chemical reaction inside cell n produce effect
exp:Ach is agonist at muscarinic receptor in the heart cell
have affinity n intrinsic activity

Question 7

antagonist

Answer 7

drug that binds to receptor but x activate it.blocks effect of an agonist for that receptor

exp;d-tubocurarine antagonist of Ach
have affinity only

Question 8

potency

Answer 8

dose of a drug that is req to prod a defined effect

Question 9

efficacy

Answer 9

dose of a drug that is producing max effect of the drug

Question 10

ED50

Answer 10

the dose of a medication that produces a desired pharmacologic effect in 50% of subjects

Question 11

therapeutic index

Answer 11

a measure of drug safety
-higher index,safer drug