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PHARMACO B1 > anticancer drugs > Flashcards

anticancer drugs Flashcards

1
Q

alkylating agent

A

cyclophosphamide
ifosfamide
mechlorethamine
dacarbazine
busulfan

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2
Q

Antimetabolites

A

methotrexate,5-FU,cytarabine,6-MP,6-TG,Fludarabine

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3
Q

anticancer antibiotics

A

doxorubicin
daunorubicin
actinomycin D
mitomycin C

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4
Q

Platinum drugs

A

Cisplatin, Carboplatin, Oxaliplatin

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5
Q

Tyrosine kinase inhibitors

A

Imatinib, Gefitinib

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5
Q

Epipodophyllotoxins

A

Etoposide, Teniposide

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6
Q

Camptothecins

A

Topotecan, Irinotecan

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7
Q

Vinca alkaloids

A

Vincristine, Vinblastine

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8
Q

Taxanes

A

Paclitaxel, Docetaxel

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9
Q

GnRH analogues:

A

Buserelin, abarelix

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10
Q

Corticosteroids

A

Dexamethasone, Prednisolone

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11
Q

Estrogen receptor antagonist

A

Tamoxifen, Fulvestrant

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12
Q

Aromatase inhibitor

A

Letrozole, Anastrozole

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13
Q

Antiandrogens

A

Flutamide, Bicalutamide

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14
Q

G1 phase specific drug

A

L-asparaginase

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15
Q

S phase specific drugs

A

Antimetabolites
* Epipodophyllotoxins
* Camptothecins

16
Q

G2 phase specific drug

A

Bleomycin

17
Q

M phase specific drugs

A

Taxanes
*Vinca alkaloids

18
Q

Cell Cycle Non-Specific (CCNS) drugs

A

kill cells whether they are resting/actively cycling
* Alkylating agents
* Antitumor antibiotics
* Antitumor antibiotics
-Platinum analogues

19
Q

Cyclophosphamide toxicity

A

hemorrhagiccystitis

20
Q

Doxorubicin toxicity

A

cardiotoxicity

21
Q

Bleomycin toxicity

A

pulmonary fibrosis, usually presents as pneumonitis with cough, dyspnea, dry inspiratory crackles on physical examination, and infiltrates on chest x- ray

22
Q

Vincristine toxicity

A

neuropathy, syndrome of inappropriate antidiuretic hormone secretion

23
Q

Cisplatin toxicity

A

nephrotoxicity and ototoxicity

24
Q

Methotrexate toxicity

A

hepatotoxicity and nephrotoxicity, and megaloblastic anemia

25
Q

AML induction

A

cytarabine + daunorubicin

26
Q

AML maintainance

A

cytarabine + Daunorubicin/ Etoposide

27
Q

hodgkin lymphoma: ABVD regimen

A

Doxorubicin,bleomycin,vinblastine,dacarbazine

28
Q

hodgkin lymphoma: MOPP regimen

A

Mechlorethamine,Vincristine,Procarbazine,Prednisone

29
Q

non-hodgkin lymphoma: CHOP regimen

A

cyclophosphamide,doxorubicin,vincristine,prednisone

PHARMACO B1 (11 decks)

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