Definitions Flashcards
Testosterone is indicated for?
Hormonal replacement therapy in males with androgen deficiency
Thrombolytic (fibrinolytic) drugs are used for?
Acute thromboembolic disorders
Anole antifungals affect the biosynthesis of?
Fungal ergo sterols by interfering with the cytochrome P450 dependent enzyme llano sterol demethylase that catalyses ergosterol formation
Androgens, primarily testosterone, are the steroidal male sex hormones necessary for the normal?
Development and maintenance old male sex functions and characteristics
Haemostatic and anti fibrinolytic drugs are used to?
Hasten clot formation and reduce bleeding
Drug interactions are classified as either?
Pharmacodynamics or pharmacokinetic interactions
Glomerular filtration is the initial step in urine formation and involves?
Ultrafiltration of water and small salutes through pores of the glomerular capillaries into the capsular space of the Bowman’s capsule.
Immunosuppressant drugs?
Decrease or prevent an immune response
Diuresis is defined as?
Increased formation and excretion of urine
Carbapenems have a wide spectrum of activity against?
Gram positive and gram-negative aerobic and anaerobic organisms.
Neurotransmission is the process whereby?
A neurotransmitter released from a pre synaptic nerve terminal crosses the synapse and interacts with a receptor on the membrane of the post synaptic cell.
Neuropathic pain arises from?
Primary lesion or dysfunction in the somatosensory nervous system pathways.
Selective toxicity exploits differences in?
Biochemical pathways between normal hosts cells and neoplasticism cells to minimise adverse effects
Neuropathic pain responds less well to?
Opioids and NSAIDs
Growth fraction is the?
Cell population in the tumour that is actively engaged in cell cycling compared to the population in the GO phase.
The physiological actions of progesterone are to?
Stimulate the secretory phase; maintain endometrium in preparation for implantation and nourishment; decrease the level of ofluteneinising hormone and the synthesis of oestrogen receptors; relax uterine smooth muscle; and increase core body temperature
The cardiac output is a function of both?
The degree of stretch of heart fibres before contraction (preload), the force of contraction of the ventricles and the pressure that must be overcome before the ventricles can eject the blood (after load)
selective toxicity exploits differences in?
Biochemical pathways between normal host cells and neoplastic cells to minimise adverse effects
Tear fluids is lost by?
Evaporation and nasolacrimal drainage
The therapeutic properties of NSAIDs include?
Analgesic, antiinflammatory and anti-pyre tic effects
The vitreous humour is a?
Gel like viscous fluid-collagen matrix that comprises about 80% of the volume of the eye and bathes the retina.
The 3 subtypes of muscrainic receptors that are relevant pharmacologically are?
- the neural type (M1)
- the cardiac and pre synaptic type (M2)
- the glandular or smooth muscle type (M3)