Defence system Flashcards
Common myeloid
progenitor (CMP) form…
dendritic cell macrophage neutrophil eosinophil mast cell megakaryote red blood cell (erythrocyte)
Common lymphoid
Progenitor (CLP) form…
B cell
helper T cell
killer T cell
natural killer cell
Haematopoietic stem cells (HSCs) form…
Common myeloid
progenitor (CMP)
Common lymphoid
Progenitor (CLP)
phagocytic cells
dendritic cell
macrophage
neutrophil
what is on a cell which tells immune cells it is ‘normal’?
major histocompatibility complex 1
where are major histocompatibility complex class II found?
on professional antigen presenting cells
…macrophages, dendritic cells, B cells
Pattern recognition receptors (PRRs)
broadly-specific, germline-encoded receptors
one gene > one receptor
found on the surface of phagocytic cells
e.g. toll-like receptors (TLRs)
PAMPs:
pathogen-associated molecular patterns
e.g. LPS, CpG DNA,
dsRNA, ssRNA
B cell groups
memory
effector - antibody producing
T cell groups
cytotoxic T cells (killer)
helper T cells
- raise alarm with cytokines
-> stimulates maturation of B cells
Two main important classes of immunoglobulins
IgG
IgM
Where is IgG found?
Plasma, Placenta
What is the structure of IgG?
Monomer
What is the structure of IgM?
Pentamer
Where is IgM found?
B cell receptor & plasma
