Ddx of aggressive lesions Flashcards
Lab findings in osseous destruction
increase serum ca, P04, ALP, tot protein, ESR, CRP
lab findings in blastic mets
Increased acid phosphatase, PSA
In what age is sclerotic mets mc
> 40
<40 not as common
what is the ration of M:F for multiple myeloma
2:1 M:F
Clinical pres of multiple myelma
Bone pain (relieved @ night) Anemia fatigue Renal failure Usually lytic
What are the 2 types of multiple myeloma
Diseminated
- Multiple punched out lytic lesions
- Diffuse osteopenia
Solitary
- Plasmacytoma
Imaging findings in multiple myeloma (2)
multiple intramedullary punched out lytic lesions Endosteal scalloping (into cortex from inner surface)
What will you not see in imaging in multiple myeloma
No reactive sclerosis
no perosteal rxn
no soft tiss
What will u see in blood and urine tests for multiple myeloma
Blood- reverse a/g ratio, CBC, serum immunoelectrophoresis (m spike)
Urine- Bence jones pro
Where does lymphomas originate
lymph system
what is the most common look of lymphomas
can be blastic/ mixed but usually lytic
Clinical pres of lymphomas (age, pain, symp etc)
all ages
- painless enlargement of lymph nodes/spleen
- Fever/night sweats/ fatigue/ weight loss
- Bone pain/ chest pain
Lab findings of hodgkins lymphoma
Elevated Reed- sternberg cells
Non hodgkins lymphoma loc, matrix/border, rxn
Loc- central diaphyseal (pelvis, femur, humerus)
Imaging- ill defined lesions that are permiative/moth eaten, minimal perosteal rxn
Hodgkins lymphoma loc, matrix/border
loc- usually spine, pelvis, ribs, femur, sternum (axial)
Imaging- 75% lytic
