Day 7 A&E Flashcards

1
Q

Name an example of an inotrope

What is an inotrope

A

digoxin

clinically, if the word inotrope is used it typically refers to positive inotropes.

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2
Q
  • A 38 year old woman is hypoxaemic in the ED.
  • Her SpO2 in air was 93%.
  • She has been started on oxygen via a nasal cannulae.

Which is the lowest flow rate (L/min) of oxygen that is recommended through a nasal cannulae as emergency oxygen therapy?

Which is the highest flow rate (L/min) of oxygen that is recommended through nasal cannulae as emergency oxygen therapy?​

A

Which is the lowest flow rate (L/min) of oxygen that is recommended through a nasal cannulae as emergency oxygen therapy?

1L/min

Which is the highest flow rate (L/min) of oxygen that is recommended through nasal cannulae as emergency oxygen therapy?​

6L/min

The upper range of oxygen delivery from nasal cannulae is a little lower than the output of a simple face mask, but the lower range goes a lot lower than a simple face mask which should not be used below a flow rate of 5 L/min (about 40% oxygen).

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3
Q

What is TCAD

A

A triple combination antiviral drug (TCAD) regimen comprised of amantadine, oseltamivir, and ribavirin

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4
Q

Which venturi valve is needed to provide an Fi02 of 40%?

What oxygen flow rate is required to produce an Fi02 of 40%?

If you turn up the flow rate above this, will you increase the amount of oxygen that the patient receives?

A

Which venturi valve is needed to provide an Fi02 of 40%?

red

What oxygen flow rate is required to produce an Fi02 of 40%?

10L

If you turn up the flow rate above this, will you increase the amount of oxygen that the patient receives?

no

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5
Q

A 42 year old woman is hypoxaemic in the ED.

Her SpO2 in air was 90%. She has been started on oxygen via a simple face mask.

What is the flow rate range of a simple face mask?

What is the range of oxygen concentration which can be delivered?

Who is this mask suitable for?

A

What is the flow rate range of a simple face mask?

  • 5-10L/min

What is the range of oxygen concentration which can be delivered?

  • This flow rate gives a wide oxygen concentration range, providing an FiO2 from ∼40% to ∼60%

​Who is this mask suitable for?

  • This mask is suitable for patients with respiratory failure without hypercapnia (type 1 respiratory failure)
  • but is not suitable for patients with hypercapnic (type 2) respiratory failure.
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6
Q

What is the difference between type 1 and type 2 respiratory failure?

A

type 1

  • hypoxaemic respiratory failure
  • caused by a problem with Oxygen getting into the lungs
  • seen as normal CO2 but low Oxygen

type 2

  • hypercapnic respiratory failure
  • caused by blocking/narrowing/respiratory muscle failure
  • seen as low oxygen but high carbon dioxide
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7
Q

When would you use a CPAP?

A
  • type 1 resp failure
  • weaning off a ventilator
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8
Q

A 38 year old woman with asthma is wheezy and hypoxaemic.

A non-rebreathe mask has been attached to the piped wall-oxygen and turned on to 15 L/min.

Which is the next action to take before applying the mask to the patient’s face?

(3)

A

Before putting the mask onto the patient, the valve inside the mask should be held down, allowing the reservoir bag to inflate.

Inflating the ‘bag’ creates an oxygen-rich atmosphere which the patient inspires (maximally 85% oxygen).

Not inflating the bag will provide the patient with a far lower oxygen concentration- in critical illness, this will result in sub-optimal resuscitation and could have serious consequences.

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9
Q

Nasal cannulae

Flow rates

Oxygen delivered

A

1L/min = 24%

2L/min = 28%

4L/min = 36%

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10
Q

Venturi Masks

Blue flow rate + percentage

White flow rate + percentage

Yellow flow rate + percentage

Red flow rate + percentage

Green flow rate + percentage

Non-rebreather flowrate + percentage

A

Blue flow rate + percentage

2-4L/min =24%

White flow rate + percentage

2-6L/min = 28%

Yellow flow rate + percentage

8-10L/min = 35%

Red flow rate + percentage

10-12L/min = 40%

Green flow rate + percentage

12-15L/min = 60%

Non-rebreather flowrate + percentage

15L/min = 100%

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11
Q

A 50 year old woman with suspected COVID-19 was severely hypoxaemic upon arrival to the ED.

The cubicles were full so she was placed onto a trolley and given oxygen via a non-rebreathe mask, using the device shown.

Despite this management, she remains profoundly hypoxaemic.

A

The image shows a non-rebreathe oxygen mask attached to a portable compressor.

This machine is used to deliver bronchodilator nebulisers (e.g. salbutamol or ipratropium bromide).

It drives these therapies through air.

The compressor has no oxygen delivering capacity and oxygen masks must NEVER be attached to them.

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12
Q

A 63 year old woman has had a productive cough and intermittent high temperatures for 48 hours.

She describes feeling exhausted and breathless.

She lives with her wife who is a newsagent and is asymptomatic.

She normally takes amlodipine for hypertension and is otherwise fit and well.

  • Temperature 37.9℃,
  • P 130 bpm regular
  • BP 110/65mmHg, RR 28
  • 6L/min via a simple face mask giving SpO2 90% on

What are her target SATS?

How should oxygen be provided to her?

A

We commonly use two oxygen target ranges in clinical practice:

  • 88-92% for patients at risk of hypercapnic respiratory failure`§
  • 94-98% for the majority of people (where hypercapnic respiratory failure is not anticipated).

What are her target SATS?

This woman’s oxygen target range is 94-98% because we are not suspecting she has any risk factors for type-2 respiratory failure.

How should oxygen be provided to her?

  • She does not appear to be critically ill.
  • Therefore, the most appropriate oxygen strategy is to titrate-up her flow rate using the simple face mask.
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13
Q

What is the flow rate of a simple face mask?

What is the oxygen percentage range on a simple face mask?

A

What is the flow rate of a simple face mask?

5-10L/min

What is the oxygen percentage range on a simple face mask?

40-60%

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14
Q

A 67 year old woman has had a dry cough and intermittent high temperatures for 48 hours.

She describes feeling exhausted and has a headache.

She lives with her husband who is a vicar and is asymptomatic.

She normally takes amlodipine for hypertension and is otherwise fit and well.

Observations show:

  • Temperature 37.9℃,
  • P 110 bpm regular,
  • BP 110/65mmHg,
  • RR 28, SpO2 90% on air.

What are her target SATS?

What approach should be taken towards her oxygen supplementation?

A

What are her target SATS?

  • 88-92% for patients at risk of hypercapnic respiratory failure
  • 94-98% for the majority of people (where hypercapnic respiratory failure is not anticipated).
  • This woman’s oxygen target range is 94-98%.

What approach should be taken towards her oxygen supplementation?

  • Start oxygen via nasal cannulae and titrate according to response
  • She does not appear to be critically ill.
  • Therefore, the most appropriate oxygen strategy is to titrate her oxygen therapy, starting low and working upwards.
  • The most appropriate oxygen device to use first is nasal cannula.
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15
Q

A 62 year old woman has had a dry cough and intermittent high temperatures for 48 hours.

She describes feeling exhausted and has a headache. She lives with her husband who is retired and is well.

She normally takes amlodipine for hypertension and paracetamol for back pain but is otherwise fit and well.

Observations show: Temperature 38.9℃, P 140 bpm irregular, BP 90/65mmHg, RR 28, SpO2 78% on air., GCS E3V4M6 (13).

What are her target SATS?

What approach should be taken towards her oxygen supplementation?

A

This woman’s oxygen target range is 94-98% because we are not suspecting she has any risk factors for type-2 respiratory failure.

Start 15L/min via a non-rebreathe mask

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16
Q

What is the normal pH range on an ABG?

A

7.35 - 7.45

17
Q

What is the normal pCO2 range on an ABG?

A

4.67 - 6.00 kPa

18
Q

What is the the normal oxygen range on an ABG?

A

10.00 - 13.33kPa

19
Q

What is the normal bicarbonate range an an ABG?

A

22 - 26 mmol/L

20
Q

What might low bicarbonate mean on an ABG?

A

it has been used to buffer carbonic acid

there is insufficient excretion from the kidneys

21
Q

What is the normal range of base excess on ECG?

A

-2 to +2

22
Q

What is the normal range for Sodium Na on an ABG?

A

135 -148 mmol/L

23
Q

What is the normal range for Potassium K on an ABG?

A

3.50 - 5.30 mmol/L

24
Q

What is the normal range of calcium on an ABG?

A

1.13 - 1.32 mmol/L

25
Q

Normal chloride range on an ABG?

A

98-106 mmol/L

26
Q

What is the normal range of lactate on an ABG

A

0.50 - 2.00 mmol/L

27
Q

Causes of HYPOKALAEMIA

Medications (5)

Gastrointestinal (3)

Transcellular ShiftS (2)

Renal (3)

Endocrine (1)

A

Medications

  • Thiazide and loop diuretics
  • Aminoglycosides
  • Bo-agonists
  • Adrenal steroids
  • Chronic laxative abuse

Gastrointestinal

  • Vomiting
  • Severe Diarrhea
  • Gastric outlet obstruction

Transcellular Shifts

  • Alkalosis
  • Insulin

Renal

  • Renal tubular acidosis
  • Magnesium deficiency
  • Levodopa or gentamicin use

Endocrine

  • Diabetic ketoacidosis
28
Q

Whart is the drug “Tacrolimus” used for?

A

to prevent organ rejection

29
Q

Rheumatoid arthritis treatments

DMARDs

(5)

A

DMARDs

  • methotrexate is the most widely used DMARD. Monitoring of FBC & LFTs is essential due to the risk of myelosuppression and liver cirrhosis. Other important side-effects include pneumonitis
  • sulfasalazine
  • Azathioprine
  • leflunomide
  • hydroxychloroquine
30
Q

Rheumatoid arthritis test and referral criteria

A

Refer urgently, within 3 working days of presentation (even with a normal acute-phase response, negative anti-cyclic citrullinated peptide [CCP] antibodies or rheumatoid factor) if there are any of the following:

  • Small joints of the hands or feet are affected.
  • More than one joint is affected.
  • There has been a delay of 3 months or longer between the onset of symptoms and the person seeking medical advice
31
Q

Antibodies associated with renal disease to be aware of, all of which could present with a pulmonary-renal syndrome:

Goodpasture’s syndrome (1)

Granulomatosis with polyangiitis (Wegener’s) (1)

Churg-Strauss (1)

SLE (3)

Rheumatoid arthritis (2)

A

Goodpasture’s syndrome

  • Anti-glomerular basement membrane antibodies against type 4 collagen found within glomerular and alveolar basement membranes

Granulomatosis with polyangiitis (Wegener’s)

  • Cytoplasmic anti-neutrophil cytoplasmic antibodies

Churg-Strauss

  • Peri-nuclear anti-neutrophil cytoplasmic antibodies

SLE

  • Antinuclear antibody
  • double-stranded DNA
  • anti-smith antibody are more specific

Rheumatoid arthritis

  • Rheumatoid factor
  • anti Anti-Cyclic Citrullinated Peptide (anti-CCP) is more specific
32
Q

Tumour marker for pancreatic cancer

Tumour marker for breast cancer

A

CA 19-9 - Pancreatic cancer

CA 15-3 - Breast cancer