D1_L2 Pt 3: Water Soluble Vitamins 2 Flashcards
______ competes with pyridoxine for enzymes
Isoniazid
Think (B)ISONiazid and OX compete for plant foods
Pyridoxine toxicity is _____
Irreversible
Deficiency symptoms of pyridoxine
Think GRASP
Glossitis (inflamed tongue)
Rashes
Anemia
Seizures
Peripheral neuropathy
Sources of pyridoxine
Think While traveling by OX you see YuCCA plants
Yeast
u
Cereals
Corn
Animal Sources
Primary functions of biotin (4)
Energy production
Nutrient metabolism
A co-enzyme in rxns including AA metabolism, fatty acid synthesis, & converting pyruvate to oxaloacetate
Involved in gene expression
Biotin is formed by _____ _____
_____ binds biotin, causing it to be ______
Intestinal bacteria
Avidin
Inactivated
Think IN - biotIN is INactivated by avidIN
Deficiency symptoms of biotin
Think in bio lab we measure in GRAMs
Glossitis
Rashes
Alopecia
Muscle damage
s
Sources of biotin
Think KYLE is my bio lab partner
Kidney
Yeast
Liver
Egg yolk
Functions of folate
Acts as a coenzyme in DNA synthesis
RBC formation
Decreases neural tube defects
Folate is synthesized from ______
Folate is ___-dependent because _____
PABA
Zinc
Zinc makes folate absorbable
Folate deficiency symptoms
Think folate/football STADIUm
Shortness of breath
Tiredness
Anemia (megaloblastic, marocytic)
Diarrhea
Irritability
Ulcers
m
Sources of folate
Think folate BLoCKs neural tube defects
Beans
Leafy greens/lentils/liver
o
Cereal/citrus fruits
Kidney
s
Functions of cyanocobalamin
A coenzyme in synthesizing proteins (homocysteine to methionine)
RBC production
Maintains nerve fiber sheaths
Steps of cyanocobalamin absorption
HCL & pepsin unbind B12 from foods
Free B12 binds with intrinsic factor (IF)
B12 & IF travel to small intestine for absorption
Deficiency symptoms of cyanocobalamin
Megaloblastic (large RBC), macrocytic (large RBC), & pernicious anemia (autoimmune)