D. 6) Neutrophil Extravasation

Question 1

neutrophils

Answer 1

a type of phagocyte. phagocytes engulf bacteria and destroy them

Question 2

rolling adhesion of neutrophil involve what components

Answer 2

selectin, chemokine and chemokine receptor

Question 3

what is the first step when there is an infection in a tissue (rolling adhesion)

Answer 3

the endothelium is signaled, it expresses an adhesion molecule selectin. slectin bound by a neutrophil surface molecule. movement of blood disrupts this interaxn. results in repeated binding and breaking free, producing a tumbling movement. slows cell down

Question 4

what occurs during tight binding

Answer 4

binding of CXCL8 to neutrophil’s CXCL8R sends a signal inside the neutrophil results in conformation change in a neutrophil surface protein called intergrin

Question 5

fn of integrin

Answer 5

bind tightly to an Ig -superfamily cell adhesion molecule (ICAM) on the endothelium lining the blood vessels

Question 6

diapedesis and migration

Answer 6

CXCL8 is produced by resident macrophage in the tissues in response to infection. neutrophil squeezes through gaps btwn cells of endothelium and moves up a gradient of chemoattractrants to site of infection

Question 7

name some chemoattractants

Answer 7

CXCL8 and C5a, a component of the complement system