Cytokines of Innate Immunity Flashcards
Actions and Source of Tumor Necrosis Factor (TNF)
-Activates inflammation/coagulation in endothelial cells
-Activates neutrophils
-Fever in Hypothalamus
-Synthesis of acute phase proteins in liver
-Catabolism in muscle and fat (cachexia)
-Apoptosis in many cells
Source: Macrophages and T cells
-Activates inflammation/coagulation in endothelial cells
-Activates neutrophils
-Fever in Hypothalamus
-Synthesis of acute phase proteins in liver
-Catabolism in muscle and fat (cachexia)
-Apoptosis in many cells
Source: Macrophages and T cells
Actions and Source of Tumor Necrosis Factor (TNF)
IL-1(beta)
Activates vascular endothelium
Activates lymphocytes
Local Tissue destruction
Increases access to effector cells
Activates vascular endothelium
Activates lymphocytes
Local Tissue destruction
Increases access to effector cells
IL-1(beta)
IL-8
chemotactic factor
recruits neutrophils, basophils, and t-cells to site of infection
IL-12
- Activates NK cells
- Induces differentiation of CD4 T cells into Th1 cells
IL-6
Lymphocyte activation
Increased antibody production
chemotactic factor
recruits neutrophils, basophils, and t-cells to site of infection
IL-8
- Activates NK cells
- Induces differentiation of CD4 T cells into Th1 cells
IL-12
Lymphocyte activation
Increased antibody production
IL-6
What two cytokines stimulate growth in number of NK cells
IL-15 and IL-2
What cytokine stimulates activity of NK cells
IL-12
Pselectin or E selectin
Initiate rolling
L selectin
Stabilizes rolling
MCP-1 or MIP-1
Transmigration of macrophages
