Cytokines AI generated Flashcards
Describe the role of TGF- in the immune system.
TGF-β restrains the immune system by causing Th-cell to turn into iTreg, reducing proliferation, and inhibiting CTLS.
What is the function of IL-10 in the immune system?
IL-10 binds to IL-10R on APC to reduce T-cell and APC activation.
Define Th1 cells and their relation to Crohn’s disease.
Th1 cells, when activated by IL-12, produce IFN-γ and are related to Crohn’s disease.
How does IL-4 contribute to the immune response in Th2 cells?
IL-4 acts as a growth factor for Th2 cells and B-cells, aiding in the production of IgE antibodies against allergies.
Describe the activation process of Th17 cells in the immune system.
Th17 cells are activated by IL-6, TGF-β, and IL-23, with IL-23 acting as a growth factor for Th17 cells.
What is the role of Type I Interferons (IFN-α/β) in the immune system?
Type I Interferons alert cells and exhibit antiviral activity.
How do nTregs regulate the immune response?
nTregs produce IL-10 and TGF-β, which are anti-inflammatory and inhibit the action of T-cells, ultimately shutting down APCs.
Do NK-cells release IFN-γ?
Yes, NK-cells can release IFN-γ as part of the immune response.
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