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I & I Part I > Cytokines > Flashcards

Cytokines Flashcards

1
Q

IL-2

A
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2
Q

IL-4

A

•delivered by APC —> GATA-3 —> Th2

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3
Q

IL-5

A
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4
Q

IL-6

A

•delvered by APC –> RORyT —> Th17

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5
Q

IL-7

A
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6
Q

IL-10

A
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7
Q

IL-12

A

••delvered by APC —> T bet –> Th1

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8
Q

IL-15

A
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9
Q

IL-17

A
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10
Q

IL-23

A
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11
Q

IFN-I (α & β)

A

•delvered by APC —> T bet –> Th1

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12
Q

IFN-γ

A

•delvered by APC —> T bet –> Th1

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13
Q

TGF-β

A
  • delivered by APC —> FoxP3 –> Treg
  • delivered by APC –> RORyT —> Th17
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14
Q

TNF-α

A
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15
Q

Neutralization Antibodies

A
  • IgG 1-4 +++
  • IgA +++
  • IgM +
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16
Q

Opsonization Antibodies

A
  • IgG1 +++
  • IgG3++
  • IgG4 +
  • IgA +
17
Q

Sensitization for killing by NK cells Antibodies

A
  • IgG1 ++
  • IgG3 ++
18
Q

Sensitization of Mast cells Antibodies

A
  • IgE +++
  • IgG1 +
  • IgG3 +
19
Q

Activation of Complement System Antibodies

A
  • IgM +++
  • IgG3 +++
  • IgG1++
  • IgG2 +
  • IgA +
20
Q

Antibodies that can transport across epithelium

A
  • IgA +++ (dimer in mucosa)
  • IgM +
21
Q

Antibodies that can transport across placenta

A
  • IgG1 +++
  • IgG3 ++
  • IgG4 ++
  • IgG2 +
22
Q

Antobodies that can diffuse into extravascular sites

A
  • IgG1-4 +++
  • IgA ++ (monomer in serum)
23
Q

Antibodies in serum (mg/ml)

A
  • IgG1 9
  • IgG2 3
  • IgA 2.5
  • IgM 1.5
  • IgG3 1
  • IgG4 0.5
  • IgD 0.03
  • IgE 5 x 10(-5)
24
Q

L-selectin

A
  • CD4+
  • resting adhesion molecule, keeps T cell in LN
25
Q

VLA-4

A
  • CD4+
  • adhesion molecule
  • This integrin interacts with vascular cell adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels near the sites of inflammation. That allows effector T cells to migrate into tissues and eliminate infection.
26
Q

LFA - 1

A
  • Naive T-Cell
  • adhesion molecule
  • .Naïve T cells express leukocyte function-associated antigen 1 (LFA1) which binds to intercellular adhesion molecule 1 (ICAM-1) on APC.
27
Q

CD 2

A
  • CD4+
  • adhesion molecule
28
Q

CD 4

A
  • CD4+
  • adhesion molecule
  • signal transduction
  • Class II MHC ligand on APC
29
Q

CD 8

A
  • signal transduction
  • Class I MHC ligand on all nucleated cells
30
Q

CD28

A
  • CD4+
  • signal transduction (costimulation)
  • B7-1/B7-2 ligand on APC
31
Q

CTLA-4

A
  • CD4+
  • inhibition
  • B7-1/B7-2 ligand on APC
32
Q

PD-1

A
  • CD4+
  • inhibition
  • PD-L1/PD-L2 ligand on APC, tissue cells, tumor cells
33
Q
A

I & I Part I (25 decks)

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