Cytokines Flashcards
1
Q
IL-2
A
2
Q
IL-4
A
•delivered by APC —> GATA-3 —> Th2
3
Q
IL-5
A
4
Q
IL-6
A
•delvered by APC –> RORyT —> Th17
5
Q
IL-7
A
6
Q
IL-10
A
7
Q
IL-12
A
••delvered by APC —> T bet –> Th1
8
Q
IL-15
A
9
Q
IL-17
A
10
Q
IL-23
A
11
Q
IFN-I (α & β)
A
•delvered by APC —> T bet –> Th1
12
Q
IFN-γ
A
•delvered by APC —> T bet –> Th1
13
Q
TGF-β
A
- delivered by APC —> FoxP3 –> Treg
- delivered by APC –> RORyT —> Th17
14
Q
TNF-α
A
15
Q
Neutralization Antibodies
A
- IgG 1-4 +++
- IgA +++
- IgM +
16
Q
Opsonization Antibodies
A
- IgG1 +++
- IgG3++
- IgG4 +
- IgA +
17
Q
Sensitization for killing by NK cells Antibodies
A
- IgG1 ++
- IgG3 ++
18
Q
Sensitization of Mast cells Antibodies
A
- IgE +++
- IgG1 +
- IgG3 +
19
Q
Activation of Complement System Antibodies
A
- IgM +++
- IgG3 +++
- IgG1++
- IgG2 +
- IgA +
20
Q
Antibodies that can transport across epithelium
A
- IgA +++ (dimer in mucosa)
- IgM +
21
Q
Antibodies that can transport across placenta
A
- IgG1 +++
- IgG3 ++
- IgG4 ++
- IgG2 +
22
Q
Antobodies that can diffuse into extravascular sites
A
- IgG1-4 +++
- IgA ++ (monomer in serum)
23
Q
Antibodies in serum (mg/ml)
A
- IgG1 9
- IgG2 3
- IgA 2.5
- IgM 1.5
- IgG3 1
- IgG4 0.5
- IgD 0.03
- IgE 5 x 10(-5)
24
Q
L-selectin
A
- CD4+
- resting adhesion molecule, keeps T cell in LN
25
VLA-4
* CD4+
* adhesion molecule
* This integrin interacts with vascular cell adhesion molecule-1 (VCAM-1), expressed on the endothelium of blood vessels near the sites of inflammation. That allows effector T cells to migrate into tissues and eliminate infection.
26
LFA - 1
* Naive T-Cell
* adhesion molecule
* .Naïve T cells express leukocyte function-associated antigen 1 (LFA1) which binds to intercellular adhesion molecule 1 (ICAM-1) on APC.
27
CD 2
* CD4+
* adhesion molecule
28
CD 4
* CD4+
* adhesion molecule
* signal transduction
* Class II MHC ligand on APC
29
CD 8
* signal transduction
* Class I MHC ligand on all nucleated cells
30
CD28
* CD4+
* signal transduction (costimulation)
* B7-1/B7-2 ligand on APC
31
CTLA-4
* CD4+
* inhibition
* B7-1/B7-2 ligand on APC
32
PD-1
* CD4+
* inhibition
* PD-L1/PD-L2 ligand on APC, tissue cells, tumor cells
33
