Cytokines

Question 1

The ability of a single cytokine to alter the expression of several genes is called

a. redundancy.
b. pleiotropy.
c. autocrine stimulation.
d. endocrine effect.

Answer 1

b. pleiotropy

Question 2

Which of the following can be attributed to IL-1?

a. Mediator of the innate immune response
b. Differentiation of stem cells
c. Halts growth of virally infected cells
d. Stimulation of mast cells

Answer 2

a. Mediator of the innate immune response

Question 3

Which of the following are target cells for IL-3?

a. Myeloid precursors
b. Lymphoid precursors
c. Erythroid precursors
d. All of the above

Answer 3

d. All of the above

Question 4

A lack of IL-4 might result in which of the following?

a. Inability to fight off viral infections
b. Increased risk of tumors
c. Lack of IgE
d. Decreased eosinophil count

Answer 4

c. Lack of IgE

Question 5

Which of the following is also known as the T-cell growth factor?

a. IFN
b. IL-12
c. IL-2
d. IL-10

Answer 5

c. IL-2

Question 6

Which chemokine receptor does HIV need for cellspecific binding?
a. CCR1
b. CCR3
c. CCR4
d. CCR5

Answer 6

d. CCR5

Question 7

IFN-α and IFN-β differ in which way from IFN-у?

a. IFN- α and IFN-β are called immune interferons, and IFN- у is not.
b. IFN- α and IFN-β primarily activate macrophages, while IFN-у halts viral activity.
c. They are made primarily by activated T cells, while IFN-у is made by fibroblasts.
d. IFN-α and IFN-β inhibit cell proliferation, while IFN- β stimulates antigen presentation by class II
MHC molecules.

Answer 7

d. IFN-α and IFN-β inhibit cell proliferation, while IFN- β stimulates antigen presentation by class II
MHC molecules

Question 8

A patient in septic shock caused by a gram-negative bacterial infection exhibits the following symptoms:
high fever, very low blood pressure, and disseminated intravascular coagulation. Which cytokine is the most likely contributor to
these symptoms?

a. IL-2
b. TNF
c. IL-12
d. IL-7

Answer 8

b. TNF

Question 9

IL-10 acts as an antagonist to what cytokine?
a. IL-4
b. TNF- α
c. IFN- у
d. TGF-β

Answer 9

c. IFN- у

Question 10

10. Which would be the best assay to measure a specific cytokine?

a. Blast formation
b. T-cell proliferation
c. Measurement of leukocyte chemotaxis
d. ELISA testing

Answer 10

d. ELISA testing