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Medicine Unit 3 > Cytokines > Flashcards

Cytokines Flashcards

1
Q

G-CSF

A

granulocyte colony stimulating factor

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2
Q

cells that produce G-CSF

A

basic tissue cells
fibroblasts

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3
Q

function of G-CSF

A

stimulates neutrophil production and their release into the blood

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4
Q

IFN alpha

A

interferon alpha

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5
Q

which cells make IFN alpha

A

infected cells
usually viruses

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6
Q

what does IFN alpha do

A

increases anti-viral responses
increases MHC1 levels on cells
causes autocrine release of IFN beta

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7
Q

IFN beta

A

interferon beta

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8
Q

what cells make IFN beta

A

infected cells
usually viruses

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9
Q

what does IFN beta do

A

increases anti-viral responses
increase MHC1 levels on cells

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10
Q

IFN gamma

A

interferon gamma

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11
Q

which cells make IFN gamma

A

T cells
normally Th1
NK cells
intraepithelial cells
lymphocytes in MALTs

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12
Q

what does IFN gamma d o

A

activates macrophages
increases presentation of antigens on MHC2
induces class switching of B cells
suppresses th2 and Th17

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13
Q

which cells make IL-1 beta

A

macrophages and epithelial cells

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14
Q

function of IL-1 beta

A

pro inflammatory
fever
activation of vascular endothelium to allow immune cells into tissues
T cell activation
macrophage activation

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15
Q

which cells produce IL-2

A

T cells

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16
Q

function of IL-2

A

T cell growth factor
promotes T cell proliferation and effector function

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17
Q

which cells produce IL-4

A

antigen presenting cells
Th2 cells

18
Q

what is the function of IL-4

A

causes differentiation of naive T cells into Th2
Th2 make IL-4 which cause class switching of B cells

19
Q

which cells produce IL-5

A

antigen presenting cells
Th2 cells

20
Q

function of IL-5

A

similar to IL-4
also produces eosinophils

21
Q

which cells produce IL-6

A

tissue clls
macrophages
endothelial cells
t cells
B cells

22
Q

function fo IL-6

A

pro inflammatory
fever
activation of vascular endothelium to recruit immune cells
acute phase protein production
generation of Th17 and follicular helper T cells from naive T cells

23
Q

which cells produce IL-8

A

macrophages
epithelial
other tissue cells

24
Q

function of IL-8

A

chemokine
attracts neutrophils into tissue

25
Q

which cells produce IL-10

A

antigen presenting cells
T cells
B cells

26
Q

function of IL-10

A

anti-inflammatory
suppresses responses of immune cells by stopping other cytokine production
induce naive T cells to become t reg cells

27
Q

which cells produce IL-12

A

antigen presenting cells

28
Q

function of IL-12

A

induces naive T cells to differentiate into Th1 which Make IFN gamma

29
Q

which cells produce IL-13

A

Th2

30
Q

function of IL-13

A

helps B cell differentiation
inhibits macrophages and Th1 cells

31
Q

which cells produce IL-17

A

th17 cells

32
Q

function of IL-17

A

increases anti-microbial responses and proinflammatory cytokine production in tissues

33
Q

which cells produce IL-21

A

follicular helper T cells

34
Q

function of IL-21

A

maintaining germinal centre
promoting lymphocyte proliferation
encourage cells to become Th17

35
Q

which cells produce IL-22

A

Th17 cells

36
Q

function of IL-22

A

increases acute phase responses and pro inflammatory cytokine production in tissues

37
Q

which cells produce IL-23

A

antigen presenting cells

38
Q

function of IL-23

A

induces Th17 cell differentiation and proliferation

39
Q

which cells produce transforming growth factor beta

A

antigen presenting cells and T cells

40
Q

function of transforming growth factor beta

A

induces Th17 cells
induces class switching to IgA

41
Q

which cells produce tumour necrosis factor alpha

A

macrophages
NK cells
T cells

42
Q

function of tumour necrosis factor alpha

A

pro inflammatory
fever
activation of vascular endothelium to allow immune cells into tissue

Medicine Unit 3 (28 decks)

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