Cytokines Flashcards
G-CSF
granulocyte colony stimulating factor
cells that produce G-CSF
basic tissue cells
fibroblasts
function of G-CSF
stimulates neutrophil production and their release into the blood
IFN alpha
interferon alpha
which cells make IFN alpha
infected cells
usually viruses
what does IFN alpha do
increases anti-viral responses
increases MHC1 levels on cells
causes autocrine release of IFN beta
IFN beta
interferon beta
what cells make IFN beta
infected cells
usually viruses
what does IFN beta do
increases anti-viral responses
increase MHC1 levels on cells
IFN gamma
interferon gamma
which cells make IFN gamma
T cells
normally Th1
NK cells
intraepithelial cells
lymphocytes in MALTs
what does IFN gamma d o
activates macrophages
increases presentation of antigens on MHC2
induces class switching of B cells
suppresses th2 and Th17
which cells make IL-1 beta
macrophages and epithelial cells
function of IL-1 beta
pro inflammatory
fever
activation of vascular endothelium to allow immune cells into tissues
T cell activation
macrophage activation
which cells produce IL-2
T cells
function of IL-2
T cell growth factor
promotes T cell proliferation and effector function
which cells produce IL-4
antigen presenting cells
Th2 cells
what is the function of IL-4
causes differentiation of naive T cells into Th2
Th2 make IL-4 which cause class switching of B cells
which cells produce IL-5
antigen presenting cells
Th2 cells
function of IL-5
similar to IL-4
also produces eosinophils
which cells produce IL-6
tissue clls
macrophages
endothelial cells
t cells
B cells
function fo IL-6
pro inflammatory
fever
activation of vascular endothelium to recruit immune cells
acute phase protein production
generation of Th17 and follicular helper T cells from naive T cells
which cells produce IL-8
macrophages
epithelial
other tissue cells
function of IL-8
chemokine
attracts neutrophils into tissue
which cells produce IL-10
antigen presenting cells
T cells
B cells
function of IL-10
anti-inflammatory
suppresses responses of immune cells by stopping other cytokine production
induce naive T cells to become t reg cells
which cells produce IL-12
antigen presenting cells
function of IL-12
induces naive T cells to differentiate into Th1 which Make IFN gamma
which cells produce IL-13
Th2
function of IL-13
helps B cell differentiation
inhibits macrophages and Th1 cells
which cells produce IL-17
th17 cells
function of IL-17
increases anti-microbial responses and proinflammatory cytokine production in tissues
which cells produce IL-21
follicular helper T cells
function of IL-21
maintaining germinal centre
promoting lymphocyte proliferation
encourage cells to become Th17
which cells produce IL-22
Th17 cells
function of IL-22
increases acute phase responses and pro inflammatory cytokine production in tissues
which cells produce IL-23
antigen presenting cells
function of IL-23
induces Th17 cell differentiation and proliferation
which cells produce transforming growth factor beta
antigen presenting cells and T cells
function of transforming growth factor beta
induces Th17 cells
induces class switching to IgA
which cells produce tumour necrosis factor alpha
macrophages
NK cells
T cells
function of tumour necrosis factor alpha
pro inflammatory
fever
activation of vascular endothelium to allow immune cells into tissue
