Cystic fibrosis - Inhaled Antibiotics for Chronic Suppressive Therapy

Question 1

Why is inhalation the preferred route for administration of tobramycin and aztreonam?

Answer 1

Antibiotics are used long-term to suppress chronic infection with P. aeruginosa..

Why? Because this route achieves high concentrations in the airway while
minimizing the risk for systemic toxicity. However, because treatment is prolonged, resistance
is a concern.

Question 2

How do these two drugs work in suppressive therapy for cystic fibrosis?

Answer 2

Both drugs improve pulmonary function, reduce
the density of P. aeruginosa in sputum, and decrease the risk for hospitalization.

Question 3

tobramycin a/e?

Answer 3

Common adverse effects
include cough, wheezing, and hoarseness. In contrast to IV aminoglycosides, inhaled
tobramycin is unlikely to cause hearing loss, although it can cause tinnitus

Question 4

aztreonam a/e?

Answer 4

Principal adverse effects are cough, nasal congestion, and
wheezing.

Question 5

What is the connection between Cystic fibrosis and P. aeruginosa?

Answer 5

Pseudomonas aeruginosa is a major opportunistic pathogen causing chronic lung infections in people with cystic fibrosis (CF), leading to accelerated lung function decline and increased mortality.