CVS - Lipids Lowering Medication Flashcards
What is the correlation between coronary artery disease and plasma lipoproteins?
Coronary artery disease is correlated with the levels of plasma cholesterol and/or triacylglycerol-containing lipoproteins.
What are chylomicrons?
Chylomicrons are lipoproteins formed in the intestinal mucosa, transporting dietary triglycerides, cholesterol, and other lipids.
What role does VLDL play in the body?
VLDL transports endogenously synthesized triglycerides from the liver to adipose tissue and skeletal muscle.
What is the primary role of LDL?
LDL primarily transports cholesterol to peripheral tissues and is involved in the formation of cholesterol plaques in arteries.
How does HDL contribute to lipid metabolism?
HDL is involved in reverse cholesterol transport, carrying cholesterol away from the plasma and tissues to the liver for excretion.
What is the exogenous pathway of cholesterol transport?
The exogenous pathway involves the absorption and transport of dietary cholesterol and triglycerides from the intestines to the liver.
Describe the endogenous pathway of cholesterol transport.
The endogenous pathway transports endogenously synthesized cholesterol and triglycerides from the liver to peripheral tissues.
What is Type I hyperlipoproteinemia?
Type I hyperlipoproteinemia is characterized by elevated chylomicrons due to a deficiency in lipoprotein lipase or its co-factor.
Which lipoprotein is elevated in Type IIa hyperlipoproteinemia?
In Type IIa hyperlipoproteinemia, LDL is elevated.
What causes Type IV hyperlipoproteinemia?
Type IV is caused by an overproduction or decreased clearance of VLDL.
What dietary changes are recommended for dyslipidemia treatment?
Recommendations include reducing saturated fats, trans fats, and cholesterol, and increasing fibre intake.
What is the mechanism of action of PCSK9 inhibitors?
PCSK9 inhibitors block the protein PCSK9, increasing the number of LDL receptors in the liver and lowering LDL cholesterol levels in the plasma.
How do fibrates lower lipid levels?
Fibrates decrease triglyceride levels by activating PPAR-?, enhancing lipolysis and elimination of triglyceride-rich particles.
What is the role of omega-3 acid ethyl esters in lipid lowering?
Omega-3 acid ethyl esters reduce hepatic triglyceride synthesis, lowering VLDL and triglyceride levels.
How do bile acid binding resins lower cholesterol?
They bind bile acids in the intestine, preventing their reabsorption and causing the liver to use more cholesterol to make bile acids.
What is the action of ezetimibe in cholesterol lowering?
Ezetimibe inhibits intestinal absorption of cholesterol, leading to reduced plasma cholesterol levels.
What is the primary action of HMG-CoA reductase inhibitors (Statins)?
Statins inhibit HMG-CoA reductase, reducing cholesterol synthesis in the liver and increasing hepatic LDL receptor expression.
How do PCSK9 inhibitors differ from statins?
PCSK9 inhibitors block a protein that degrades LDL receptors, while statins inhibit cholesterol synthesis in the liver.
What are the clinical uses of fibrates?
Fibrates are primarily used to lower triglyceride levels and increase HDL cholesterol levels.
In which condition are omega-3 acid ethyl esters particularly effective?
They are effective in lowering triglycerides in hypertriglyceridemia.
When are bile acid binding resins prescribed?
They are used in hypercholesterolemia, particularly when statins are contraindicated or insufficient.
What is the pharmacokinetic property of ezetimibe?
Ezetimibe is absorbed and extensively conjugated to a pharmacologically active phenolic glucuronide.
What are the common adverse effects of statins?
Common adverse effects include myalgia, increased liver enzymes, and a risk of diabetes.
Name a significant adverse effect of PCSK9 inhibitors.
PCSK9 inhibitors can cause injection site reactions.
What are the adverse effects of fibrates?
Fibrates can cause gastrointestinal disturbances, gallstones, and myopathy.