CVS CONDITIONS Flashcards
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - DEFINITION
- VBI is when blood flow to the back of your brain reduces or stops
- VBI affects the parts of the brain that controls balance and movement
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - RARE TYPE
A rare type of VBI is transient vertebral artery insufficiency (also called Bow Hunter syndrome) and it is caused by turning/rotating the head
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - CAUSE
- Atherosclerosis commonly causes VBI
o Atherosclerosis occurs when plaque forms from calcium and cholesterol build up in the arteries - Other common causes
o Penetrating artery disease
o Pulmonary embolism
o Vertebral artery dissection - Less common causes
o Blood disorders (coagulopathies)
o Drug addiction
o Fibromuscular dysplasia
o Migraine headaches
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - POPULATION AFFECTED
Men over 50
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - RISK FACTORS
- Coronary artery disease
- Peripheral artery disease
- Diabetes
- Family history
- Hypertension
- High cholesterol
- History of smoking
- Obesity
- Atherosclerosis
- Hyperlipidemia
- Heart conditions that cause a blocked artery also increase the risk of VBI
o Arterial fibrillation
o Blood clotting disorders
o Infective endocarditis
o Vertebral artery dissection - Men
- Black people
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - CLINICAL PRESENTATION
- Balance problems - Dizziness, Vertigo
- Confusion
- Dysphagia
- Ataxia
- Double vision/loss of vision
- Syncope
- Loss of balance
- Nausea and vomiting
- Numbness in part of the body
- Dysarthria
- Drop attacks
- Urinary incontinence
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - DIAGNOSIS
- Imaging – CT or MRI
- Angiography
- CTA or MRA
- Echocardiogram
- Electrocardiogram
- Holter monitor
- Prothrombin time (PT) and partial thromboplastin tine (PTT) blood tests
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - TREATMENT - LIFESTYLE CHANGES
o Achieving a healthy weight
o Controlling cholesterol by changing diet
o Increasing exercise
o Quitting smoking
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - TREATMENT - MEDICATIONS
- Medications to help manage health problems
o Blood clots
o Blood pressure
o Cholesterol
o Diabetes
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - TREATMENT - SURGERY
o Carotid endarterectomy – removing plaque from the carotid artery
o Coronary angioplasty and stent – inserts a small balloon with a stent into an artery in the heart to open it up
o Coronary artery bypass – replace a damaged blood vessel in the heart with a healthy one
o Vertebral artery reconstruction – fix the damage to the arterys that carry blood to that brain
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - TREATMENT FOR TRANSIENT VBI
o Brace/collar
o Medication
o Surgery, including minimally invasive spine surgery
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - PREVENTION
- You can reduce the risk by
o Eating a healthy diet
o Exercising regularly
o Keeping cholesterol under control
o Managing other health conditions – hypertension and diabetes
o Quite smoking
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - PROGNOSIS
- Prognosis depends on
o Severity of brain function issues
o Whether you have had a stroke
o Age
o Other health conditions - Serious causes may lead to disability or death
- Most people are able to manage symptoms with medications and lifestyle changes
- VBI has a recurrence rate of 10% to 15%
VERTEBRAL ARTERY INSUFFICIENCY (VBI) - LONGTERM EFFECTS
o DVT
o Pulmonary embolism
o Dehydration/swallowing problems
o Difficulty breathing
o Paralysis or numbness
o Gastritis
o Myocardial infarction
o Lung infections
o Bedsores
o Stroke/TIA
o Vision loss
ABDOMINAL AROTIC ANEURYSM (AAA) - DEFINITION
- AAA is a potentially life-threatening condition
- It’s a bulge in the main artery that supplies blood to the belly, pelvis and legs
- The aneurysm is a weak spot in the blood vessel wall, at risk of rupturing and causing a haemorrhage
ABDOMINAL AROTIC ANEURYSM (AAA) - CAUSE
- The following diseases can damage the blood vessel walls or cause weak spots
o Atherosclerosis
o Cardiovascular disease
o Peripheral artery disease (PAD)
o Traumatic injuries that cause tears in the artery wall
o Smoking
o Vasculitis
o Genetic diseases that affect connective tissues – Marfan syndrome, Ehlers Danlos type IV
ABDOMINAL AROTIC ANEURYSM (AAA) - POPULATION AFFECTED
Men over 65
ABDOMINAL AROTIC ANEURYSM (AAA) - RISK FACTORS
- Smoking
- Being a woman over 70
- Personal history of an aneurysm in another site, especially in the lower extremities
- Family history
- High blood pressure
- High cholesterol
- Obesity
ABDOMINAL AROTIC ANEURYSM (AAA) - CLINICAL PRESENTATION
- Most people don’t have symptoms until the aneurysm is close to rupturing
- You may experience
o Back, leg or abdominal pain that doesn’t go away
o Pulsing sensation in the belly - Signs of a ruptured AAA
o Clammy, sweaty skin
o Dizziness
o Fainting
o Fast heartbeat
o Nausea and vomiting
o Shortness of breath
o Sudden, severe pain in the belly, lower back or legs - This is a medical emergency
ABDOMINAL AROTIC ANEURYSM (AAA) - DIAGNOSIS
- They don’t have symptoms so healthcare providers often diagnose unruptured AAAs when performing screening exams or tests
- These include
o Abdominal ultrasound
o Computed tomography angiography (CTA)
ABDOMINAL AROTIC ANEURYSM (AAA) - TREATMENT
- Treatment depends on the size of the aneurysm
- Aneurysms less than 5cm have a low risk of rupturing and may not need treatment right away
- “Watchful waiting” is recommended
o Getting ultrasounds every few months to make sure the aneurysm isn’t getting bigger
o Making lifestyle adjustments
Exercising
Not smoking
Eating a healthy diet
Avoiding alcohol
Maintaining a healthy weight
Taking medication to lower blood pressure - Surgery
o Open surgery – incision in the belly and a graft is sewn onto the bulging section of the aorta
o Endovascular aneurysm repair (EVAR) – minimally invasive aneurysm repair surgery. Uses a small incision in the groin and the use of a catheter into an artery with an expandable stent to reinforce the aneurysm and prevent rupture
ABDOMINAL AORTIC ANEURYSM (AAA) - PREVENTION
- Can’t always prevent AAA, especially is there is a family history of the condition
- Screening is available to spot it early
- Early detection and the right treatment may prevent the aneurysm from getting larger or rupturing
- Can control risk factors
o Stopping smoking
o Exercising
o Eating a healthy diet
o Managing weight, blood pressure and cholesterol
o Avoiding drinking too much alcohol
ABDOMINAL AROTIC ANEURYSM (AAA) - PROGNOSIS
- Outlook is poor for people with an AAA that ruptures – 80% mortality rate
- About 70% of people who have surgery before their aneurysm reptures live at least another 5 years
- Prognosis is good for people with small AAAs detected during screening, especially if they improve their cardiovascular health risk factors
CERVICAL ARTERY DISSECTION (CAD) - DEFINITION
- CAD happens when there is a tear in one or more layers of blood vessel tissue
- It is a common cause of stroke in young and middle-aged adults
CERVICAL ARTERY DISSECTION (CAD) - CAUSE
- Injury to your head or neck is the most common cause of dissection
- Non-traumatic dissections can occur due to straining or heavy lifting in some people
CERVICAL ARTERY DISSECTION (CAD) - POPULATION AFFECTED
People ages 40 – 60
CERVICAL ARTERY DISSECTION (CAD) - RISK FACTORS
- Connective tissue disorders
o Ehlers-Danlos syndrome
o Fibromuscular dysplasia
o Marfan syndrome
o Osteogenesis imperfecta - Recent illnesses
o Gastrointestinal upset that causes frequent vomiting
o Upper respiratory infection with persistent coughing - Atherosclerosis
- Hypertension
- Smoking
CERVICAL ARTERY DISSECTION (CAD) - CLINICAL PRESENTATION
- Many people start noticing symptoms up to a month before receiving a CAD diagnosis
- There are 3 main types
- Head or neck pain
- Horner’s syndrome
- Stroke-like symptoms
CERVICAL ARTERY DISSECTION (CAD) - CLINICAL PRESENTATION - HEAD OR NECK PAIN
May experience head or neck pain not related to an existing health issue
Discomfort typically comes on suddenly and doesn’t go away
Pain is on one side of the head (especially behind one eye) or neck and often resembles a cluster, migraine or thunderclap headache
CERVICAL ARTERY DISSECTION (CAD) - CLINICAL PRESENTATION - HORNER’S SYNDROME
Condition that affects the involuntary function of the eyes and face
Symptoms include:
Drooping eyelids
Smaller pupil in one eye
Lack of sweating
Typically only impacts one side of the head
CERVICAL ARTERY DISSECTION (CAD) - CLINICAL PRESENTATION - STROKE-LIKE SYMPTOMS
CAD symptoms occur when part of the brain isn’t getting enough blood
Ataxia
Balance problems
Blurred vision
Dizziness
Diplopia
Limb weakness
Dysarthria or aphasia
Vertigo
CERVICAL ARTERY DISSECTION (CAD) - DIAGNOSIS
- CTA
- MRA
- Any technique that takes specific pictures of the blood vessels
CERVICAL ARTERY DISSECTION (CAD) - TREATMENT
- They often heal on their own
- Medical therapies can lower the risk of blood clots that can lead to stroke
- Antiplatelet therapy – aspirin and clopidogrel
- Anticoagulant medications – heparin infusion or warfarin tablets
- Rarely, stenting is necessary
CERVICAL ARTERY DISSECTION (CAD) - PREVENTION
- Important to have monitoring from a vascular specialist
- All people at risk for CAD should optimise their health by
o Avoiding prolonged extreme neck positions
o Avoiding rapid head and neck movements
o Avoiding heavy lifting
o Eating a heart-healthy diet
o Exercise regularly
o Maintaining blood pressure
o Quitting smoking
CERVICAL ARTERY DISSECTION (CAD) - PROGNOSIS
- They often heal on their own
- Typically heals very well, returning the vessel to normal
- Process usually occurs within the first 3 to 6 months
DEEP VEIN THROMBOSIS (DVT) - DEFINITION
- Deep vein thrombosis occurs when a thrombus (blood clot) develops in veins deep in the body because the veins are injured or the blood flowing through them is too sluggish
- The blood clots may partially or completely block blood flow through the vein
- Most DVTs happen in the lower leg, thigh or pelvis but can also occur in other parts of the body including the arm, brain, intestines, liver or kidneys
DEEP VEIN THROMBOSIS (DVT) - CAUSE
- Anything that prevents the blood from flowing or properly clotting can cause a blood clot
- The main causes of DVT are damage to a vein from surgery or inflammation and damage due to infection or injury
DEEP VEIN THROMBOSIS (DVT) - POPULATION AFFECTED
- Can occur at any age
- Less common in children and adolescents
- More common in those over 60
DEEP VEIN THROMBOSIS (DVT) - RISK FACTORS
- Having an inherited condition increases the risk of blood clots
- Having cancer and some of its treatments
- Having a history of DVT in yourself or your family
- Having limited blood flow in a deep vein because of an injury, surgery or immobilisation
- Not moving for long periods of time
- Being pregnant or recently having a baby
- Over 40
- Being obese
- Autoimmune disease
o Lupus
o Vasculitis
o IBD - Smoking
- Having varicose veins
- Taking birth control
DEEP VEIN THROMBOSIS (DVT) - CLINICAL PRESENTATION
- Usually forms in the veins of your legs or arms
- Up to 30 % of people with DVT don’t have any symptoms but sometimes the symptoms are very mild and don’t raise concern
- Symptoms of acute DVT include
o Swelling of the leg or arm
o Pain or tenderness in your leg or arm
o The area of your leg or arm that’s swollen or hurts may be warmer than usual
o Skin that’s red or discoloured
o The veins near your skins surface may be larger than normal
o Abdominal pain or flank pain
o Severe headache and/or seizures (when blood clots affect the veins of your brain) - Some people don’t know they have a DVT until the clot moves from their leg or arm and travels to their lung
DEEP VEIN THROMBOSIS (DVT) - DIAGNOSIS
- Duplex venous ultrasound
- Venography
- MRI or MRV
- CT
- If someone thinks the patient may have a genetic or acquired clotting disorder you may need special blood tests
DEEP VEIN THROMBOSIS (DVT) - TREATMENT
- Anticoagulants
- Compression stockings
- Elevating the affected limb at different times throughout the day
- Sometimes more invasive treatments are requires – these are catheter based procedures
DEEP VEIN THROMBOSIS (DVT) - PREVENTION
- After you have a DVT you will have to reduce your risk of future DVT clots by
o Taking blood thinning medications
o Keeping follow-up appointments
o Making lifestyle changes such as eating healthier foods, being more active and avoiding smoking - If you have never had a DVT but have an increased risk of developing one you should
o Exercise the calf muscles if you sit for a long time - stand up and walk around every 30 mins
o Get out of bed as soon as you can if you’re sick or have had surgery
o Take medications or use compression socks after surgery
DEEP VEIN THROMBOSIS (DVT) - PROGNOSIS
- A DVT can take several months to a year to come apart
- You will need blood thinner medications and keep wearing compression stockings until you are told to stop
- May need blood tests to make sure you’re getting the right dose of blood thinners
- You may need continued ultrasounds to make sure the clot hasn’t moved or got bigger
PULMONARY EMBOLISM (PE) - DEFINITION
- A pulmonary embolism is a blood clot in the blood vessels of your lungs
- This happens when a clot in another part of the body moves through the veins to your lung
- A PE restricts blood flow tp your lungs, lowers oxygen levels in the lungs and increases blood pressure in the pulmonary arteries
PULMONARY EMBOLISM (PE) - CAUSE
- Blood pooling in a certain part of the body, usually arm or leg
- Injury to a vein
- Another medical condition – congestive heart failure, atrial fibrillation, heart attack, stroke
- Increase or decrease in the bloods clotting factors
PULMONARY EMBOLISM (PE) - POPULATION AFFECTED
Adults aged 70-80
PULMONARY EMBOLISM (PE) - RISK FACTORS
- Having a blood clot in the leg or DVT
- Being inactive for long periods of time
- Having recently had trauma or injury to a vein
- Taking birth control pills
- Currently smoking
- History of heart failure or stroke
- Being overweight
- Are pregnant or have given birth in the previous 6 weeks
- Received a central venous catheter through the arm or leg
- Having cancer or receiving cancer treatments
PULMONARY EMBOLISM (PE) - CLINICAL PRESENTATION
- Symptoms vary depending on the severity of the clot
- Some people don’t experience symptoms with a pulmonary embolism but most do
- Sudden shortness of breath – whether you are active or at rest
- Unexplained sharp pain in the chest, arm, shoulder, neck or jaw – pain may also be similar to the symptoms of a heart attack
- Cough with or without bloody mucus
- Pale, clammy or bluish skin
- Rapid heartbeat
- Excessive sweating
- Feeling anxious, light headed, faint or passing out
- Wheezing
PULMONARY EMBOLISM (PE) - DIAGNOSIS
- Blood tests – D-dimer test
- CT angiogram
- Ultrasound of the leg
- A ventilation/perfusion (V/Q) scan
- Pulmonary angiogram
- Chest x-ray
PULMONARY EMBOLISM (PE) - TREATMENT
- Hospital stay and treatment length will vary depending on the severity of the clot
- Main treatment is anticoagulants
- Compression stockings
- Thrombolytic therapy – “clot busters”
- Surgery
PULMONARY EMBOLISM (PE) - PREVENTION
- Exercise regularly
- Drink plenty of fluids, but limit alcohol and caffeine
- Don’t use tobacco products
- Avoid crossing legs
- Don’t wear tight fitting clothing
- Lose weight if you have overweight
- Elevate your feet for 30 minutes twice a day
PULMONARY EMBOLISM (PE) - PROGNOSIS
- Without treatment, a PE is a very serious condition that can lead to permanent illness or death
- With treatment, your prognosis depends on the size of the blood clot and blockages as well as overall health and how well your heart can pump blood
- It can take months or years for a PE to go away completely
- Repeated PE or a very large PE can lead to pulmonary hypertension in some people
STROKE - DEFINITION
- A stroke is a life-threatening condition that happens when a part of the brain doesn’t have enough blood flow
- This most commonly happens because of a blocked artery or bleeding in the brain
STROKE - TYPES
- 2 main ways strokes can happen – ischemia and haemorrhage
- Ischemia
o When cells don’t get enough blood flow to supply them with oxygen.
o This usually happens because something blocks blood vessels in the brain, cutting off blood flow.
o This type is most common and account for about 80% of all strokes
o Usually happens due to thrombosis, an embolism, lacunar stroke (small vessel blockage) or cryptogenic stroke (an unknown reason) - Haemorrhagic
o Cause bleeding in and around the brain
o Usually happens due to bleeding inside the brain (intracerebral) or because of bleeding into the subarachnoid space (the space between the brain and its outer covering
STROKE - CAUSE
- Ischemic
o Atherosclerosis
o Clotting disorders
o Atrial fibrillation
o Heart defects
o Microvascular ischemic disease - Haemorrhagic
o High blood pressure
o Brain aneurysms
o Brain tumours
o Diseases that weaken or cause unusual changes in blood vessels in the brain, such as moyamoya disease
STROKE - POPULATION AFFECTED
- Anyone can have a stroke
- Most common in people over 65
STROKE - RISK FACTORS
- Alcohol use disorder
- High blood pressure
- Hyperlipidaemia
- Migraine headaches
- Type 2 diabetes
- Smoking
- Drug misuse
STROKE - CLINICAL PRESENTATION
- Stroke symptoms often depend on the area of the brain that is affected
- Symptoms of stroke can lead to one or more of the following:
o One-sided weakness or paralysis
o Difficulty with or loss of speaking ability (aphasia)
o Slurred or garbled speaking (dysarthria)
o Loss of muscle control on one side of the face
o Sudden loss – partial or total – of one or more senses (vision, hearing, taste, smell and touch)
o Diplopia
o Ataxia
o Dizziness or vertigo
o Nausea and vomiting
o Neck stiffness
o Emotional instability and personality changes
o Confusion or agitation
o Seizures
o Memory loss (amnesia)
o Headaches (usually sudden and severe)
o Passing out or fainting
o Coma
STROKE - DIAGNOSIS
- Diagnosis involves a combo of neurological examination, diagnostic imaging and other tests
- CT scan
- Lab blood tests
- ECG
- MRI scan
- EEG
STROKE - TREATMENT
- Treatment depends on many factors, the most important factor in determining treatment is what kind of stroke a person has
- Ischemic
o Top priority is restoring circulation to affected brain areas
o Restoring circulation usually involves a certain medication type called thrombolytics but may also involve a catheterization procedure
o Thrombolytic drugs (within 3 to 4.5 hours)
o Thrombectomy (within 24 hours if there is no significant brain damage)
o Blood pressure management - Haemorrhagic
o Treatment depends on the location and severity of the bleeding
o Reducing blood pressure is often the top priority because this will reduce the amount of bleeding and keep it from getting worse
o Another treatment option is to improve clotting so the bleeding will stop
o Surgery is sometimes necessary to relieve pressure on the brain from accumulated blood - Rehabilitation
o Speech therapy
o Physical therapy
o Occupational therapy
o Cognitive therapy
STROKE - PREVENTION
- Improve your lifestyle
- Avoid risky lifestyle choices or make changes to your behaviours
- Manage health conditions and risk factors
- Reduce caffeine, alcohol, fried foods and recreational drugs
STROKE - PROGNOSIS
- Ischemic
o The more severe an ischemic stroke is, the worse the damage
o You are more likely to lose certain abilities, at least temporarily
o The faster you get medical attention the effects or more likely to be temporary or less severe - Haemorrhagic
o These usually cause much worse symptoms, especially when bleeding is more severe
o Symptoms tend to get worse quickly - Strokes have the potential to cause death when they are severe or if they go too long without treatment
- Outlook does depend a lot on how severe the initial stroke is
TRANSIENT ISCHEMIC ATTACK (TIA) - DEFINITION
- A TIA starts like a stroke but only lasts from several minutes up to 24 hours
- A TIA does not kill the brain cells so there is no lasting damage to the brain
- Also called a mini-stroke
TRANSIENT ISCHEMIC ATTACK (TIA) - CAUSE
- Happens when one of the blood vessels that supply the brain with oxygen-rich blood becomes blocked
- In TIAs the blockage quickly resolves and the brain’s blood supply returns to normal before there is any significant damage
- The blockage in the blood vessels responsible for most TIAs is usually caused by a blood clot that’s formed elsewhere in the body and travelled to the blood vessels supplying the brain
- It can also be caused by pieces of fatty material or air bubbles
TRANSIENT ISCHEMIC ATTACK (TIA) - POPULATION AFFECTED
Adults over 55
TRANSIENT ISCHEMIC ATTACK (TIA) - RISK FACTORS
- Older age – the risk of a stroke doubles with each decade after the age of 55 in both men and women
- Family history
- Being male
- Race – black and Hispanic have a higher risk than white people
- Hypertension
- Physical inactivity
- Diabetes
- Heart disease
- Atrial fibrillation
- Smoking
- High blood cholesterol levels
- Drug abuse
- Obesity
TRANSIENT ISCHEMIC ATTACK (TIA) - CLINICAL PRESENTATION
- Symptoms of a TIA and stroke do not differ
- Symptoms come on suddenly
- Difficulty seeing from one or both eyes
- Numbness or weakness in the face, arms or legs, especially on one side
- Severe headache
- Difficulty walking
- Dizziness, loss or coordination and balance
- Difficulty speaking or understanding words
TRANSIENT ISCHEMIC ATTACK (TIA) - DIAGNOSIS
- Simple tests to check vision, muscle strength and ability to think and speak
- CT scan
- MRI scan
- ECG
TRANSIENT ISCHEMIC ATTACK (TIA) - TREATMENT
- General approach to treating and preventing TIAs is the same as that used to treat and prevent strokes
- Aspirin and clopidogrel
- Anticoagulant drugs
- Carotid endarterectomy – surgical removal or the plaque withing the carotid artery
- Carotid angioplasty and stenting procedure
TRANSIENT ISCHEMIC ATTACK (TIA) - PREVENTION
- Stopping smoking
- Monitor blood pressure
- Monitor cholesterol
- Eat a Mediterranean-style diet
- Maintain a healthy weight
- Stop drinking alcohol
- Exercise
- Wear your CPAP
TRANSIENT ISCHEMIC ATTACK (TIA) - PROGNOSIS
- Prognosis is good
- A TIA usually lasts only a few minutes and doesn’t cause permeant damage
- However a TIA is often a warning of a stroke so it is important to look at lifestyle factors to reduce risk factors
HYPERTENSION - DEFINITION
- High blood pressure
- Blood pressure is the measurement of the pressure of blood pushing against blood vessel walls
- Hypertension means that the pressure against the blood vessel walls in the body is consistently too high
HYPERTENSION - BLOOD PRESSURE READINGS
- Normal – under 130/80 mmHg
- Stage 1 hypertension (mild) – 130-139 OR diastolic between 80-89 mmHg
- Stage 2 hypertension (moderate) – 140/90 mmHg or higher
- Hypertensive crisis (get emergency care) – 180/120 mmHg or higher
HYPERTENSION - CAUSE
- 2 types of high blood pressure
- Primary
o Most common
o Aging
o Unhealthy habits – not getting enough exercise - Secondary
o Different medical problems
o A medication you are taking