CV: Lipid Lowering

Question 1

Statins (drugs)

Answer 1

Simvastatin (Zocor) - CYP3A4Atorvastatin (Lipitor) - CYP3A4Rosuvastatin (Crestor) - CYP2C19Pravastatin (Pravachol) - glucuronidation

Question 2

Bile Acid Sequestrants/Resins (BARs) (drugs)

Answer 2

Cholestyramine (Questran)Colesevelan (WelChol)

Question 3

Cholesterol Absorption Inhibitors (drugs)

Answer 3

NPC-IL1Ezetimibe (Zetia)Usually takes with simvastatin

Question 4

Fibrates (drugs)

Answer 4

PPARalphaFenofibrate (Tricor)Gemfibrozil (Lopid)

Question 5

Niacin

Answer 5

Vitamin B3, Nicotinic Acid

Question 6

Chylomicrons targeted by

Answer 6

No drugs

Question 7

LDL targeted by

Answer 7

Statins, BAR, niacin

Question 8

LDL+VLDL targeted by

Answer 8

Statins, fibrates, niacin

Question 9

IDL, VLDL, VLDL+chylomicrons targeted by

Answer 9

Fibrates, niacin

Question 10

Statins adverse effects

Answer 10

Hepatic and musculature

Question 11

BARs side effects

Answer 11

GI related, give these drugs separately from other drugs bc will affect absorption

Question 12

BARs contraindications

Answer 12

People w/ high triglycerides! Because they may increaseIn combination with statins, these may be additive

Question 13

Cholesterol Absorption Inhibitor side effectsFibrate side effects

Answer 13

GI, muscle, liver (rare)

Question 14

Niacin side effects

Answer 14

Skin flushing, pruritis, GI

Question 15

Omega 3 Fatty Acids side effects

Answer 15

GI distress, “fishy burps”, increased bleeding risk, worsened glycemic control