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Pharm Q2 > ID2: Clinical Antibiotics > Flashcards

ID2: Clinical Antibiotics Flashcards

1
Q

Antimycobacterial - Dose Adjustment in Renal Insufficiency

A

INH possibly in slow acetylatorsPZAStreptomycinRifabutin if severeEthambutol

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2
Q

Antimycobacterial - NO Dose Adjustment in Renal Insuffienciency

A

INH in rapid acetylatorsRifampin

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3
Q

Antibacterials that cross BBB

A

All CCCats Die, Felines Like Meowing, Pretty Tomcats Value Zzs:AztreonamCarbapenems3rd Gen Cephalosporins (Ceftriaxone & Ceftazidine)ChloramphenicolDoxycyclineFluoroquinolonesLinezolidMetronidazolePenicillinsTMP-SMXVancomycin (w inflammation)Zosyn (Piperacillin-Tazobactam)

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4
Q

Agents to treat PRSP

A

VeRy FLaT: (+CC)Vancomycin +/- RifampinFluoroquinolones (Respiratory - Levofloxin, Moxifloxacin)LinezolidTigecyclineCeftriaxoneCeftaroline

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5
Q

Agents for VRE

A

DaptomycinQuinupristin/Dalfopristin (but not Enterococcus faecalis)LinezolidTigecycline

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6
Q

Agents for MRSA

A

VancomycinCeftarolineLinezolidDaptomycinQuinupristin/DalfopristinTigecycline

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7
Q

Agents for Anaerobic Bacterial Infections

A

some Penicillins v. some anaerobesCefoxitin & Cefotetan (2nd Gen)CarbapenemsBeta Lactamase Inhibitor - Beta Lactam combosSome Fluoroquinolones v. some anaerobesVancomycin (Gm + only)Telavancin (Gm + only)Dalfo/Quinu v. some anaerobesLinezolid v. some anaerobesTelithromycin v. some anaerobesClindamycinChlormaphenicolTetracyclinesTigecyclineMetronidazole

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8
Q

Interact w CYP 450

A

Quinupristin/DalfopristinErythromycin & ClarithromycinTelithromycinChloramphenicolTMP/SMXFluoroquinolonesMetronidazoleIsoniazidRifampin

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9
Q

Dose adjustment HEPATIC insufficiency (Antibacterials, antimycobacterials, antifungals)

A

CDN MET PIERICephalosporins (Cefoperazone, Ceftriaxone)ChloramphenicolClindamycinDalfopristin/QuinupristinNafcillinMetronidazoleErythromycinTigecyclinePZAItraconazoleEchinocandinsRifampinIsoniazid

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10
Q

Antibacerial - Dose adjustment in RENAL insufficiency

A

“All BBoys Can Drive Fast = Motors Vehicle TTTragedies”AminoglycosidesBeta-lactams (except natural amino and extended spectrum penicillins)Beta-lactamase InhibitorsClarithromycinDaptomycinFluoroquinolonesMetronidazoleVancomycinTetracyclines (except Doxy, mino, tige)TelithromycinTrimethoprim/Sulfonamides

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11
Q

Pseudomonas Aerginosa

A

Beta-lactam + AminoglycosideSpecifically:Piperacillin3rd Gen cephalosporins, 4th Gen (Cefepime)CarbapenemsAminoglycosidesQuinolonesColistin

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12
Q

CA MRSA

A

TMP/SMXClindamycinLinezolid

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13
Q

CRE/KPCCarbapenem Resistant Enterobacteriaceae/Klebsiella Pneumoniae Carbapenemase

A
  • resistant to all beta-lactams + aminoglycosides, fluoroquinolonesTigecyclineColistinAztreonamRifampinFosfomycin
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14
Q

CLABSI

A

Vancomycin

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15
Q

CAP

A

3rd gen cephalosporin + macrolidequinolone (newer)

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16
Q

Meningitis

A

Ceftriaxone or Cefotaxime + Vancomycin(+ampicillin if at risk for Listeria)

17
Q

Fever + Neutropenia

A

Anti-pseudomonal beta-lactams (cefepime, Piperacillin/Tazobactam, carbapenems)Vancomycin only if suspect MRSA, CVC infection, hypotension, HAP

18
Q

Inta-abdominal Infection

A

Ampicillin + Metronidazole + GentamycinBeta-lactamase InhibitorsCarbapenems3rd Gen cephalosporin + MetronidazoleCipro + MetronidazoleTigecycline

19
Q

Diabetic Foot Ulcers

A

Beta-Lactamase InhibitorsImipenemTigecycline

20
Q

Urethritis

A

(Treat both GC and Chlamydia trachomatis because often travel together)Ceftriaxone + DoxycyclineAzithromycinQuinolones

21
Q

Encapsulated organisms

A

“Some Killers Have Nice CAPSULES”Strep. pneumoniaeKlebsiellaH. influenzaeNeisseria

Pharm Q2 (7 decks)

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