CV drugs: hypertension

Question 1

What drugs are used in the treatment of Hypertension?

Answer 1

1. <55:  ACE I / ARB
   >55 / african:  CCB
2.  ACEI + CCB
3. ACEI + CCB + Thiazide diuretic
4. + Spironolactone

Question 2

ACE Inhibitor used in hypertension?

Answer 2

Lisinopril

Question 3

Mode of action of Lisinopril?

Answer 3

Blocks conversion of Angiotensin I to Angiotenisn II

Question 4

Side effects of Lisinopril?

Answer 4

Dry cough

Hypotension

Question 5

Angiotension Receptor Blocker used in hypertension?

Answer 5

Losartan

Question 6

Mode of action of Losartan?

Answer 6

AT1 receptor antagonism causes:

-venous and arteriolar dilatation

Question 7

Side effects of Losartan?

Answer 7

Hypotension and dizziness

Question 8

Calcium Channel Blocker used in hypertension?

Answer 8

Amlodipine

Question 9

Mode of action of Amlodipine?

Answer 9

Block α1-adrenoceptors, reducing Ca2+ influx and muscle contraction:
-vasodilatation

Question 10

Side effects of Amlodipine?

Answer 10

Ankle oedema

Hypotension & dizziness

Question 11

Thiazide diuretic used in hypertension?

Answer 11

Bendroflumethiazide

Question 12

Mode of action of Bendroflumethiazide?

Answer 12

Inhibits reabsorption of Na+ in the loop of Henle, thus promoting water excretion.

Question 13

Side effects of Bendroflumethiazide?

Answer 13

Hypokalaemia (arrhythmias, tiredness)

Hyponatraemia

High uric acid (gout)
Hypercalcaemia
Hyperglycaemia (diabetes)

Question 14

Counter-indication of Spironolactone?

Answer 14

Hyperkalaemia