CV: Anti-cholesterol drugs

Question 1

What drugs are used for hypercholesteraemia?

Answer 1

Statins
Bile-binding resins
Ezetemibe

Question 2

Mode of action of Statins (e.g. Simvastatin)?

Answer 2

Block HMG CoA enzymes:

• promote LDL uptale by liver
• reduce LDL production

Question 3

Side effects of Simvastatin?

Answer 3

Myopathy

Do not use in pregnancy

Question 4

Bile-binding resin prescribed?

Answer 4

Cholestyramine

Question 5

Mode of action of Cholestyramine?

Answer 5

Promotes excretion of bile salts, increasing cholesterol conversion to bile salts

Question 6

Mode of action of Ezetimibe?

Answer 6

Reduces cholesterol absorption