CV and Psychiatry Flashcards
Which CV drug has been linked to depression but not proven
Beta-blockers; espicially the lipophilic ones (carvedilol, metoprolol, propranolol)
Thiazide diuretics effect on lithium
Increase lithium levels
Loop diuretics and ACEi effect on lithium
varied risk of toxicity
Example drug interactions
Beta-blockers and SSRIs:
-SSRIs block 2D6; 2D6 metabolizes beta-blockers
Clonidine and mirtazapine:
-Have opposite effects at central alpha2 receptors
Schizophrenia mortality rates
Have been increasing; possibly due to increased CVD risk factors
Most common CV risk factor seen in schizophrenia
Smoking, obesity, dyslipidemia, HTN
Most common CV risk factor seen in bipolar
Smoking, HTN, Obesity
Metabolic syndrome; etiology
Schizophrenia; antipsychotic medications may contribute; most by olanzipine
Antipsychotic-induced weight gain risk factors
younger age, lower initial BMI, famHx of obesity, non-white
Which antipychotic was shown to be most causing of metabolic syndrome
Olanzapine
Which antipyschotic was shown to cause the most weight gain
Clozapine (after 10 weeks) and olanzapine (after 1 year)
What CV event can be caused by antipsychotics
Long QT
Which antipsychotics prolong QT the most
Thioridazine
Citalopram
Ziprasidone
When are U waves seen
Hypokalemia, long QT syndrome
Tricyclic antidepressants and clinical indications
Amitriptyline Nortriptyline Chlorpromazine Imipramine Desipramine Doxepin
Uses- migraines, neuropathy, chronic pain, anxiety/depression
