Curs 6. Ereditate poligen-multifact

Question 1

Susceptibilitatea

Answer 1

factori genetici mai multe gene nealele

Question 2

boli cu determinism multifact

Answer 2

conditionat genetice nu propriu-zis genetice

Question 3

Culoarea irisului loci

Answer 3

HERC2 OCA2

Question 4

Locus imp par

Answer 4

MC1R

Question 5

Procentul de factori genetici implicati în dezvoltarea unui caracter multifactorial poarta
numele de

Answer 5

Heritabilitate(h)

Question 6

identificarea genelor candidat

Answer 6

studiile de înlantuire-asociere, si repsectiv studiile GWAS (Genome
Wide Association Study).

Question 7

Polimorfismele genei ACE

Answer 7

factor de risc in aparitia hipertensiunii arteriale esentiale

Question 8

NOD2/CARD15

Answer 8

in boala Crohn

Question 9

ADAM33

Answer 9

in astmul bronsic

Question 10

alelele HLA

Answer 10

in diverse boli autoimune

Question 11

polimofismelor genelor CFH si HTRA

Answer 11

degenerescenta maculara legata de varsta

Question 12

CDKN2A si CDKN2B

Answer 12

sindroamele coronariene

Question 13

TCF7L2 si

CDKAL1

Answer 13

diabetul zaharat de tip 2

Question 14

FTO

Answer 14

obezitate si multe altele.

Question 15

Teste functionale ale genelor candidat

Answer 15

tehnica knock-in.