Curative guidelines

Question 1

Which diseases do CURATIVE always recommend antithrombotic therapy for (dogs only)?

Answer 1

Immune-mediated haemolytic anaemia
Protein-losing nephropathy

Question 2

Which diseases do CURATIVE suggest antithrombotic therapy is considered for (dogs only)?

Answer 2

Pancreatitis
Glucocorticoid administration

Particularly when other risk factors for thrombosis exists

Question 3

What are the CURATIVE recommendations for antithrombotic use in hyperadrenocorticism in dogs?

Answer 3

HAC alone does not warrant antithrombotic therapy unless there are other risk factors for thrombosis

Question 4

What are the CURATIVE recommendations for antithrombotic use in cancer in dogs

Answer 4

Considered when hypercoagulability is demonstrated or when other risk factors for thrombosis exist

Question 5

What are the CURATIVE recommendations for antithrombotic use in sepsis in dogs?

Answer 5

Insufficient evidence evidence to support routine administration
Considered when hypercoagulability is demonstrated or when other risk factors for thrombosis exist

Question 6

What are the CURATIVE recommendations for antithrombotic use in cerebrovascular disease?

Answer 6

Cerebrovascular disease is more likely to be caused by a thrombotic event than be the cause of one
Antithrombotic therapy should be considered when an ischaemic stroke is identified and a concurrent medical condition associated with thrombosis is identified

Question 7

What are the CURATIVE recommendations for antithrombotic use in heart disease in cats?

Answer 7

Feline cardiomyopathy is strongly associated with aortic thromboembolism (ATE)
Cats with a history of ATE, left atrial dilation or reduced left atrial appendage flow velocity may be at particular risk
Antithrombotic therapy is recommended in cats with cardiomyopathy - particular with the above risk factors

Question 8

What are the CURATIVE recommendations for antithrombotic use in heart disease in dogs?

Answer 8

Not associated with high risk for thrombosis
Considered in individual dogs where other risk factors for thrombosis exists

Question 9

How do CURATIVE define high risk?

Answer 9

Dogs with IMHA or PLN
Cats with cardiomyopathy and associated risk factors
Dogs or cats with > 1 disease/risk factor for thrombosis (e.g. pancreatitis with sepsis

Question 10

How do CURATIVE define low/moderate risk?

Answer 10

Dogs or cats with a single risk factor/disease
Dogs or cats with known risk factor conditions that with treatment are likely to resolve in days to weeks

Question 11

What are the recommendations with regards to antiplatelet drugs versus anticoagulants for venous thromboembolism?

Answer 11

Dogs:
Anticoagulants may be more effective than anti-platelets agents for VTE prevention especially in dirofilariasis
Cats:
Suggest that anticoagulants rather than anti-platelets agents be used for prevention of VTE

Question 12

What are the recommendations with regards to antiplatelet drugs versus anticoagulants for aortic thromboembolism?

Answer 12

Dogs:
Antiplatelet agents may be more effective for prevention of ATE than anticoagulants
Anticoagulants may be effective for prevention of ATE

Cats:
Recommend that antiplatelet agents be used for ATE prevention in cats
No evidence for anticoagulant recommendations

Question 13

Clopidogrel versus aspirin

Answer 13

Clopidogrel may be more effective than aspirin in dogs in ATE

Recommend that clopidogrel by used instead of aspirin in cats with ATE

Question 14

New antiplatelet agents versus clopidogrel or aspirin

Answer 14

Insufficient evidence to suggest that abciximab and ticargrelor (dogs only) versus clopidogrel or aspirin but they appear safe and may be efficacious