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CSIM > CSIM 1.6 > Flashcards

CSIM 1.6 Flashcards

1
Q

what does transformation mean?

A
  • loss of contact inhibition
  • loss of anchorage
  • redcued cohesion
  • immortality
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2
Q

what does oncogene mean?

A
  • mutated or activated gene that contributes to neoplasia
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3
Q

how are oncogene activated by?

A
  • inappropriate expression

- structural alteration

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4
Q

what are proto-oncogene?

A
  • unaltered cellular counterpart of an oncogene
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5
Q

what are tumour suppressor gene?

A

-gene that inhibits neoplasia

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6
Q

how can a tumour occur in regards to initiation and promotion?

A
  • need for initiation and promotion
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7
Q

what kind of carcinomas do aromatic and azodyes cause?

A

bladder carcinomas

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8
Q

what kind of carcinomas do nitrosamines cause?

A

gastrointestinal carcinomas

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9
Q

what kind of carcinomas do nickel and chromium cause?

A
  • lung carcinomas
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10
Q

what are viral oncogene?

A
  • virus that cause cancer
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11
Q

what kind of carcinoma do human herpes virus 8 cause?

A
  • kaposi sarcoma

- immunodeficiency associated lymphoma

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12
Q

what kind of carcinoma do hepatitis B virus cause?

A

hepatocellular carcinoma

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13
Q

what kind of carcinoma do merkel cell polyoma virus cause?

A
  • merkel cell carcinoma
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14
Q

what does E6 viral oncoproteins for HPV do?

A

inhibits tumour suppressor p53

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15
Q

what does E7 viral oncoproteins for HPV do?

A

inhibits tumour suppressor Rb

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16
Q

what does EBV virus induce?

A
  • B-cell lymphoma
  • classical hodgkin lymphoma
  • Nk/t cell lymphoma
  • nasopharyngeal carcinoma
  • gastric carcinoma
17
Q

what does the LMP 1/2 viral oncoprotein do?

A
  • mimic cell signalling

- hijack growth promoting signalling pathways

18
Q

what does the EBNA - 2 viral oncoprotein do?

A
  • function as transcription factors
19
Q

what happens during G2 phase of cell cycle to ensure normal cell proliferation?

A
  • check for accurate DNA replication
20
Q

what happens during G1 phase of cell cycle to ensure normal cell proliferation?

A
  • check for DNA damage before DNA replication
21
Q

what does cyclin D/CDK4 do?

A
  • phosphorylate Rb and release E2F

CSIM (8 decks)

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