Crohn's and Ulcerative Colitis Flashcards
Which occurs more commonly in children UC or Crohn’s?
Crohn’s
Where in the GI tract does UC affect?
Begins at rectum and is continuous along the colon
What is the difference histologically between Crohn’s and UC?
Crohns= transmural UC= epithelial
What is the name for UC that only affects the rectal area?
Proctitis
Which is Th2 mediated?
UC
Which is Th1 mediated?
Crohn’s
What is the definitition of severe UC?
More than 6 bloody stools in a day + 1 of: Fever Tachycardia Anaemia Elevated ESR
In which disease is smoking protective?
UC
What is the cardinal symptoms of UC?
LIF pain
What extra intestinal manifestations can present in IBD?
Clubbing Apthous oral ulcers Erythema nodosum Pyoderma gangrenosum Angular chelitis Uevits Spondylitis Amyloidosis Episcleritis
Which disease is often characterised by peri anal disorders?
Crohns
Which is granulomatous?
Crohns
What is the definition of an extensive colitis?
extends beyond splenic flecture
What is the most worrying complication of UC?
Toxic megacolon
Which disease of the bile duct is associated with UC?
Primary sclerosing cholangitis
What is used to treat UC?
5- aminosalicyclic acid
Steroids
Immunosuppression
Anti alpha TNF therapy
Name an example of a 5-ASA
Mesalazine
In which disease is surgery not curative?
Crohns
It is curatice in UC
Where in the GI tract does crohn’s affect?
Anywhere
Characterised by ‘skip lesions’
Where is the most commonly affected site of crohns
The ileocaecal junction
What is the ‘classical’ clinical finding in crohns?
Right illiac fossa mass
What are the possible complications of crohns?
Malabsorption
Short bowel syndrome - iatrogenic
Gallstones
Strictures/bowel obsturction
What is the treatment for crohns?
Stop smoking
Steroids
Immunosuppressants
Anti- tnf
What steroids would you give in IBD?
Prednisolone
Budesonide
What immunosuppresion therapy woudld you give?
Azathipine
Mercaptepurine
Methotrexate
Name an anti TNF therapy.
Infliximab
