Coeliac Disease Flashcards
What genes are associated with coeliac?
HLA- DQ2
HLA- DQ8
What is the toxic agent in gluten?
Gliadin
What cytokine is produced?
IFN- gamma by CD4 +
How is the interepithelial lymphocytes activated?
BY binding to MIC
MIC is activated by gluten
What skin condition is associated with coeliac?
Dermatitis herpetiforms
What happens histologically in coeliac?
Villous atrophy
What are the symptoms of coeliac?
Steatorrhoea Weight loss Anaemia Diarrhoea Pain Bloating Flatus
What are two diagnostic investigations in coeliac?
IgA anti-tissue transglutaminase
Biopsy
What are the complications of coeliac?
Gallstones
Increased risk of small bowel carcinoma
Ulcerative jejenoilleitis
What is the treatment?
Gluten free diet
What in particular is poorly absorbed in coeliac?
FAT
Why is there and increased chance of gallstones developing?
Decreased Cholecystokinin - as this is produced in the lining of the small bowel
Decreased pancreatic secretion and bile flow
Which enzyme modifies MIC to allow the peptides in gluten to bond to it?
Transglutamase
