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Pharm 5 > critical stuff exam 5 > Flashcards

critical stuff exam 5 Flashcards

1
Q

life prolonging drugs in CHF

A

ACEI, ARBs, hydralazine + isosorbide dinitrate, ALD antagonists, BBlockers

vasodilators: ACEI, ARBs, hydralazine, isosorbide dinitrate

aldosterone antagonists: spironolactone & eplerenone

beta blockers: carvedilol, bisoprolol, metoprolol

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2
Q

BBlockers for CHF?

A

carvedilol, bisoprolol, metoprolol

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3
Q

bigeminy (two contractions for one SA node impulse) seen with what medication?

A

digoxin

Also causes:

  • ventricular tachycardia
  • fibrillation
  • death
  • worsens WPW
  • any arrhythmia
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4
Q

Earliest signs of digoxin toxicity?

A 
GI: 
anorexia 
nausea 
vomiting 
diarrhea
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5
Q

what to use to reverse digoxin due to toxicity?

A

digibind - monoclonal Abx

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6
Q

what receptor does dobutamine target?

A

B1, it is a positive ionotrop (adrenoreceptor agonist)

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7
Q

what causes severe neutropenia?

A

ticlopidine (antiplatelet)

check CBC q2week for first 3mo

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8
Q

what causes chinchonism (ADR)

A

quinidine (HA, tinnitus, dizziness)

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9
Q

paresthesias, tremor, nervousness, seizures, slurred speech, light headedness are ADRs of what?

A

lidocaine

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10
Q

What makes mexiletine helpful as a 1B Na blocker

A

oral (does what lidocaine does)

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11
Q

What is important to note when you use amiodarone?

A

long 1/2 life (ADRs)

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12
Q

class 4 good at treating…

A

SVT

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13
Q

first line for SVT?

A

adenosine (1/2 life of 10s = in & out)

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14
Q

what to use for atrial arrhythmias?

A 
IA
Class II (BBlockers) 
Class IV (CCB)
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15
Q

what to use for ventricular arrhythmias?

A

All class 1, II, III, & IV

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16
Q

What is used for SVT?

A 
IC
class IV (CCB)
17
Q

lengthen QT?

A 
IA
Class III (CCB)
amiodarone 
quinidine
ranolazine
dofetilide
18
Q

decrease QT?

A

IB

19
Q

increase refractory period?

A

IA, class II, class III, class IV

20
Q

increase QRS

A

IA, IC

21
Q

what works longer than ipratoprium?

A

tiotropium

22
Q

you need to monitor LFTs for hepatic injury with what two LTI?

A

Zafirlukast and Zileuton

23
Q

edema, SLE, peripheral neuropathy, drug fever are ADRs of what drug?

A

direct vasodilators (hydralazine & isosorbide dinitrate)

24
Q

what causes hyperkalemia

A

ACEI

sacubitril & valsartan

25
Q

hyperkalemia, angioedema & increased Cr are side effects of…

A

sacubitril & valsartan

26
Q

Thrombotic thrombocytopenic purpura S/E of what drug?

A

clopidogrel & ticlopidine

27
Q

thrombocytopenia?

A

heparin, LMWH, & glycoprotein IIb/IIIa, quinidine, flecainide, propafenone

28
Q

MOA of procainamide, quinidine, & dispyridamide

A

MOA: Blocks sodium channel slowing upstroke of action potential, slowing conduction of electrical impulse

29
Q

torsades

A

procainamide
sotalol
dofetilides
ibutilide

Pharm 5 (8 decks)

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