CramonFriday Flashcards
1
Q
Leptin has what effects?
A
reduces food intake and increases energy output by stimulating POMC/CART neurons and inhibiting NPY/AgRP neurons
2
Q
Peptide YY has what effects?
A
released post-prandially by endocrine cells in ileum and colon, it is a satiety signal
3
Q
Pathogenesis of NAFLD?
A
1) increased synthesis and uptake of fatty acids
2) decreased hepatic secretion of VLDL
3) decreased oxidation of fatty acids
4
Q
cytokines in metabolic syndrome?
A
IL-1, IL6, IL18, TNF
5
Q
Why do fat people get cancer?
A
1) estrogen
2) increased IGF-1
3) increased leptin (promotes cell proliferation)
4) effects on other tumor regulators like mTOR
5) chronic low level inflammation
