CPS 2019 Flashcards
The vertical rate of transmission of HIV in North America is now?
With no interventions perinatal HIV transmission rates can be as high as
well below 2%
25%
when does the majority of transmission of HIV occur?
Majority of transmission happens at the time of delivery, additional risk for infection if the newborn is breastfed
what are some risk factors for HIV
Late or no prenatal care
Injection drug use
Recent illness suggestive of HIV seroconversion
Regular unprotected sex with a partner known to be living with HIV (or risk of HIV infection)
Sexually transmitted infections during pregnancy
Emigration from an HIV-endemic area or recent incarceration
what is the standard for diagnosing HIV during pregnancy
The standard approach to diagnosing HIV infection during pregnancy is by multistep serology testing
1st step- screening for HIV antibodies using an enzyme immunoassay
If the enzyme immunoassay is reactive the sample is re-tested using a more specific confirmatory test for HIV antibodies (western blot)
If HIV test results are positive for mother or infant, infant antiretroviral prophylaxis should be initiated when?
If test results are positive for mother or infant, infant antiretroviral prophylaxis should be initiated immediately and no later than 72 hours post-delivery
Breastfeeding should be deferred until the confirmatory HIV antibody test result is available and proves negative
If a mother tests positive for HIV antibody what test should be done on the baby?
HIV (DNA or RNA) PCR within 48 hours of birth
if positive then prophylaxis should be stopped and antiretroviral treatment intitiated
* antibody test would only confirm the mother’s status
what has been identified as the single most important barrier to access of contraception?
Cost has been identified as the single most important barrier to access
what is the failure rate for IUD?IUSs? SARC?
IUDs: <1%
Short acting reversible contraception: 6-9%
OCP, patch, vaginal ring- 9% Depot- 6% IUS- 0.2% Copper IUD- 0.8% Condoms- 18-21%
what is first line for contraception
long acting reversible contraception
up to what age should have free contraception
All youth should have confidential access to contraception, at no cost, until the age of 25.
- has been shown to reduce the incidence of teen pregnancy
what are 2 antenatal strategies to reduce the incidence of acute brain injuries?
administering maternal corticosteroids
prompt antibiotic treatment for chorioamnionitis.
what infants are at higher risk for intracranial ischemic and hemorrhagic injuries? and when do they occur?
Infants born at ≤32+6 weeks gestation are at higher risk for intracranial ischemic and hemorrhagic injuries, which often occur in the first 72 hours postbirth.
The first 72 hours postbirth (‘the critical window’) is the highest risk period for acute preterm brain injury
what are some perinatal strategies to reduce the incidence of acute brain injuries? (3)
delivery within a tertiary centre
delayed cord clamping
preventing hypothermia
what are some postnatal strategies to reduce the incidence of acute brain injuries (4)
empiric treatment with antibiotics when chorioamnionitis is suspected
the cautious use of inotropes
the avoidance of blood PCO2 fluctuation (target PCO2 45-55, max 60)
neutral head positioning, HOB 30 degrees
In Canada, approximately ____% of preterm infants born at ≤32+6 weeks gestational age (GA) show an abnormal brain image (IVH or parenchymal lesions) on cranial ultrasound
21%
what age for antenatal steroids?
administering antenatal corticosteroids within 7 days to all mothers expected to deliver a premature infant ≤34+6 weeks GA is recommended, with the optimal interval being greater than 48 hours between the last dose administered and birth
what age for magnesium sulphate?
<34 weeks
what are some ways to prevent hypothermia in a preterm infant (7)
polyethylene wrapping or a bag
temperature in the delivery room at 25°C to 26°C
use a preheated servo-controlled radiant warmer with a temperature sensor
providing a thermal mattress
putting a hat on the infant
providing a preheated transport incubator
what type of ventilation should be used in preterm infants
Whenever possible, volume-targeted ventilation should be used in premature infants in the first 72 hours postdelivery
Mothers experiencing preterm premature rupture of membranes (PPROM) and expecting to deliver an infant ≤32+6 weeks gestational age (GA) should be treated with what antibiotics?
Mothers experiencing preterm premature rupture of membranes (PPROM) and expecting to deliver an infant ≤32+6 weeks gestational age (GA) should be treated with antibiotics: penicillin and a macrolide or a macrolide alone if she is allergic to penicillin
what is the best measure of stored iron
serum ferritin
what are the 3 progressive stages of iron deficiency
- depletion of iron stores
- depletion of iron transport
- iron deficiency anemia
what are risk factors for iron deficiency <2 years of age
- Male sex
- prematurity
- Low socioeconomic status
- exclusive breastfeeding >6 months
- prolonged bottle use
- lead exposure
- low dietary intake of iron-rich complementary foods
what is the recommended timing to start iron supplementation for low birth weight infants
The timing recommended for starting iron supplementation in LBW infants is at 2 to 3 weeks postnatal age
compared with 4 weeks postnatal age for infants in the normal range
For infants 7 to 12 months of age, what is the Recommended Dietary Allowance of iron
11 mg/day of elemental iron is the Recommended Dietary Allowance.
what are the iron recommendations for children 1-3 yo
4-8 years old?
iron recommendations decrease to 7 mg/day for children 1 to 3 years old
increase to 10 mg/day for children 4 to 8 years old
what are 4 ways to reduce iron deficiency in babies/infants
Delayed cord clamping
If formula feeding, providing iron-fortified formula
Feeding iron-rich complementary foods from age 6 months
Not using cow’s milk as the main milk source until infants are a year old, and limiting cow’s milk intake to 500 mL/day thereafter.
what is the treatment of iron deficiency anemia
2-6mg/kg/day divided TID
vitamin C helps with absorption
continue supplements for a minimum of 3 months
when should cows milk be introduced? how much?
delay cows milk until 9-12 months of age- 750mL
1-2 yo: 500mL
what are iron rich complimentary foods, when should they be introduced
meat
meat alternatives
iron rich cereals
introduce at 6 months
what bloodwork would you do to screen someone for iron deficiency
CBC
serum ferritin
For low birth weight infants (birth weight less than 2.5 kg) who are predominantly breastfed (i.e., greater than 50% of intake) is iron supplementation routinely recommended?
Yes!!
2.0- 2.5 kg: iron supplement of 1-2 mg/kg/day for the first 6 months of age
< 2.0 kg: 2-3 mg/kg/day for the first year of age
For low birth weight infants (birth weight less than 2.5 kg) who are predominantly formula-fed (i.e., greater than 50% of intake) is iron supplementation recommended?
Not required when the formula used is high in iron
what infants are at risk for hypoglycemia
- LGA (>90)
- SGA (<10)
- IUGR
- IDM
- Prematurity (<37 weeks)
- Maternal labetolol use
- Perinatal asphyxia
- Syndromes- such as BWS
What is the most common cause of hypoglycemia in infants?
Impairment of gluconeogenesis is the most common cause of hypoglycemia in infants
How long do you have to do glucose checks for IDM/LGA?
12 hours
How long do you have to do glucose checks for SGA?
24 hours
what is the therapeutic goal for glucose if a baby is >72 hours old
3.3