COPD Flashcards
define chronic bronchitis
productive cough for at least 3 months per year for 2 consecutive years that cannot be explained by an alternative diagnosis
define emphysema
permanent dilatation of pulmonary air spaces distal to the terminal bronchioles that is cuased by the destruction of the alveolar walls and pulmonary capillaries required for gas exchange
endogneous risk factors
lung growth and development abnormalities - recurrent pulmonary infections, premature birth
a1-antitrypsin deficiency
airway hyperresponsiveness
antibody deficiency syndrome eg. IgA deficiency
primary ciliary dyskinesia
presenting findings of COPD
chronic cough with expectoration especially in the morning
dyspnea and tachypnoea
pursed lip breathing
prolonged expiratory phase
end expiratory wheezing
crackles
muffled breath sounds
cyanosis
tachycardia
features of advanced COPD
congested neck veins
baarrel chest
use of accessory respiratory muscles due to diaphraagmatic dysfunction
hyperresonant lungs
decreased breath sounds
right heart failure and cor pulmonale
weight loss and cachexia
cor pulmonale
pulmonary heart disease
altered structure or impaired functioning of the right ventricle caused by a primary disorder of the respiratory system
pink puffers
emphysema predominating
noncyanotic
cachectic
pursed lip breathing
mild cough
blue bloater
chronic bronchitis predominating
productive cough
overweight
peripheral oedema
a1-antitrypsin deficiency
deficiency of a protease inhibitor
presents with panacinar emphysema and cirrhosis
age of onset usually younger
often also have hepatic signs and symptoms related to hepatitis or cirrhosis
centrilobular/centriacinar emphysema
most common type
seen in smokers
destruction of respiratory bronchiole (central portion of acinus) sparing distal alveoli
usually affects upper lobes
panlobular/panacinar emphysema
rarer type
associated with a1-antitrypsin deficiency
characterised by destruction of entire acinus (respiratory bronchiole and alveoli)
usually affects the lower lobes
initial tests for COPD
spirometry - FEV1/FVC ratio <0.7 after bronchodilator inhalation confirms the diagnosis
serum AAT level
what finding on spirometry is diagnostic of COPD
FEV1/FVC ratio of less than 0.7
restrictive lung disease
eg. pulmonary fibrosis
inability to inflate fully
obstructive lung disease
eg. bronchial asthma, COPD
difficulty exhaling air
assessment for respiratory failure
pulse oximetry: obtain in patients with signs of respiratory distress or signs of right heart failure
measure aat rest and on ambient air or usually oxygen prescription
ABG: obtain in patients with SO2 < 92% and/or acute illness
ABG findings of COPD
may show hypoxemic resp failure (low PO2) with or without hypercapnic respiratory failure
(high PCO2)
chronic hypercapnia due to CO2 trpping is common in patients with severe COPD