Control of gut Flashcards

1
Q

What are the methods of control of the gut?

A

Neural control

Hormonal control

Paracrine control

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2
Q

What is the neural control of the gut?

A

Autonomic nervous system control

Enteric nervous system control

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3
Q

What overall effect does sympathetic innervation have on the gut?

A

Inhibits the functions of the GI tract

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4
Q

How does the sympathetic nervous system inhibit the functions of the gut?

A

Causes vasoconstriction of blood vessels, reducing blood flow to the gut

Decreases secretions from glands

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5
Q

What neurotransmitters do the parasympathetic post-ganglionic nerve fibres release?

A

Acetylcholine

Gastrin releasing peptide

Vaso inhibitory peptide

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6
Q

What overall effect does parasympathetic innervation have on the gut?

A

Stimulates the functions of the GI tract

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7
Q

How does the parasympathetic nervous system stimulate the functions of the gut?

A

Increases motility of the gut

Increases secretions from glands

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8
Q

What are the parts of the enteric nervous system?

A

Submucosal plexus

Myenteric plexus

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9
Q

Where is the submucosal plexus located?

A

In the submucosa

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10
Q

Where is the myenteric plexus located?

A

Between the inner circulator layer and the outer longitdinal layer of the muscularis externae

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11
Q

How far along the GI tract does the enteric nervous system extend?

A

Along the whole GI tract

from the oeophagus to anus

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12
Q

What does the submucosal plexus control?

A

Secretions from epithelial cels

Local blood flow

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13
Q

What does the myenteric plexus control?

A

Motility

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14
Q

What is the relation between the autonomic and enteric nervous systems controlling the gut?

A

They are connected to each other

communicate with each other

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15
Q

What are the two families of hormones in the GI tract? What are the hormones in each family?

A

Gastrin

  • gastrin
  • cholecystokinin

Secretin

  • secretin
  • gastric inhibitory peptide
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16
Q

What types of cells produce hormones in the GI tract?

A

G cells

I cells

S cells

K cells

17
Q

What hormone do G cells produce?

A

Gastrin

18
Q

What hormone do I cells produce?

A

Cholecystokinin

19
Q

What hormone do S cells produce?

A

Secretin

20
Q

What hormone do K cells produce?

A

Gastric inhibitory peptide

21
Q

How do hormones produced in the GI tract reach their target cells?

A

Diffuse into the blood
pass through the portal circulation
pass through the systemic circulation
diffuse into target tissue

even though target tissue is close to where they were initially produced

22
Q

What is the function of gastrin?

A

Stimulates hydrochloric acid secretion from parietal cells of stomach

23
Q

What is the function of cholecystokinin?

A

Stimulates release of enzymes from pancreas

Stimulates gall bladder to contract

Relaxes sphincter of Oddi

24
Q

What is the function of secretin?

A

Stimulates increase in bicarbonate ion secretions from pancreas

Inhibits release of hydrochloric acid from parietal cells

25
Q

What is the function of gastric inhibitory polypeptide?

A

Stimulates release of insulin from pancreas

Inhibits release of hydrochloric acid from parietal cells

26
Q

What are the paracrine substances of the GI tract?

A

Somatostatin

Histamine

27
Q

What type of cell produces somatostatin?

A

D cells

28
Q

What type of cell produces histamine?

A

Enterochromaffin cells

29
Q

How do paracrine substances reach their target tissue?

A

Diffuse across short distance

to target cell which is nearby

30
Q

What is the function of somatostatin?

A

Inhibit secretion of gastrin from G cells

31
Q

What is the function of histamine?

A

Stimulate release of hydrochloride acid from parietal cells