Control - Clinical Flashcards
what is consciousness vs wakefulness
c - awareness, alertness, appropriate responses (thinking feeling etc)
w - activity of reticular activating substance from the brainstem associated with connections between cells and areas of the cerebral cortex
what is coma and how it is measured
eyes not open, no command response, no voluntary movement
not secondary use to paralytic agents
measured using Glasgow coma scale (GCS) - come = lower than 8
what is locked in syndrome
aware awake and breathe
cannot move or speak
damage to ventral pons
can blink, feel pain, autonomic system still works
what is vegetative state vs persistent VS
no evidence of awareness of self or environment
no language
no voluntary moves or expression
PVS - after 30 days not response
50% chance improve
reflex autonomic and sponanteous behaviours yes but not awareness of self or environment
what causes a vegetative state
destruction of cortex and hemispheres but intact ascending reticular activating substance
what is minimal conscious state
severely altered consciousness
reproducible but inconsistent
how do you measure level of disorders of consciousness
SMART - sensory modality assessment and rehabilitation technique
what is brain stem death and how do you test for it
no breathe or conscious, destroy brainstem, no electrical activity
absent brain stem reflexes - persistent apnoea - requires 2 assessments on two occasions
what are the three types of anaesthesia
general - total loss
regional - region or part of body
local - topical, infiltration
what are the three A’s of anaesthesia
amnesia - unconsciousness
analgesia - pain relief
akinesia - paralysis
what is balanced anaesthesia and what is the triad of balanced anaethsisa
smaller doses of a combination of drugs - max benefit and final toxic
unconsciousness , analgesia, muscle relaxation
what does the process of anaesthesia involve
induction, maintenance and reversal of process
describe how you would induce loss of consciousness
and common agents
IV - modulate transmitters gated ion channels acting on PNS/cerebral cortex/ RAS, basal ganglia, cerebellum, motor pathways
thiopentone, ketamine, etomiidate, propofol
how do we maintain loss of consciousness in aneasthtsia
vapour - NO, soflurane, desflurane
uses minimum alveolar consciousness - minimum amount of vapour to prevent reaction to standard surgical stimuli in 50% subjects
what are the problems with being under general anaesthesia for too long
hangover effects, stored in fat cells and releases slowly
amnesia, hypnosis, vasodilation, organ perfusion and hepatotoxicity
what type of agents are used for analgesia in anaesthetic
opioids - short or long acting
fentanyl, morphine, paracetamol
how do you reverse muscle relaxation in anaesthesia
reversal with neostigmine and glycopyrrolate
what is the clinical diagnosis of stroke
sudden onset
focal neurological deficit
of presumed vascular origin
symps last more than 24 hours or leading to death
if symps last less than 24 hours classed as TIA
what are the two types of strokes and how common are they
ischemic (85%) and haemorrhage (15%)
what are the causes and risks of ischamic stroke
thrombosis of large extra cranial arteries
small arteries intracranially
embolism (in the heart or vital arteries)
(most common is large vessel atherosclerosis)
risks - hypertension, obesity, diet, cardiac, diabetes
what are the best treatments for secondary stroke prevention
aspirin, warfarin - anticoagulants and decrease risk of clotting
carotid endarterectomy
drugs to lower BP such as aspirin and clopidogrel
what does FAST mean in stroke
face
arms
speech
time
what is the pathophysiology of stroke
initial reduction in cerebral blood flow - alteration sin cellar chemistry caused by ischemia and cellular necrosis
what are the thresholds of cerebral ischamia
normal is 50 ml/100g/min which can be above 20 ml
10-20 is electrical malfunctions
7.5-10 - release K and water out intracellularly
0-7.5 - cell death