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Renal Pharm > Contraindications > Flashcards

Contraindications Flashcards

1
Q

Alfuzosin, doxazosin, tamsulosin, and terazosin

A

Contraindicated for concurrent use with PDE-5 inhibitors such as sildenafil (used for ED) due to increased hypotensive effect Severe liver dysfunction with concurrent use of potent inhibitors of P450 enzymes (e.g., ketoconazole)

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2
Q

Propranolol

A

Contraindicated in asthma patients Not effective in AfricanAmerican patients; Avoid nonselective blockers (propanolol) in COPD patients

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3
Q

calcium channel blockers (diltiazem and verapamil) inhibit P450 enzymes and can increase levels PREGNANCY

A

Dutasteride

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4
Q

Bicalutamide & flutamide Antiandrogens

A

Severe hepatic impairment

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5
Q

PREGNANCY

A

Captopril, Lisinopril, Enalapril, Ramipril; Losartan, Candesartan, Valsartan, Eprosartan; Aliskiren

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6
Q

respiratory insufficiency Severe hepatic impairment

A

Nilutamide

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7
Q

Captopril, Lisinopril, Enalapril, Ramipril; Losartan, Candesartan, Valsartan, Eprosartan; Aliskiren

A

PREGNANCY

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8
Q

Concurrent use with methotrexate, 6-mercaptopurine, and azathioprine–> bone marrow suppression PREGNANCY (can cross placenta)

A

Trimethoprim-Sulfamethoxazole

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9
Q

Take with food to increase bioavailability

A

Cinacalcet

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10
Q

Alprostadil

A

Sickle cell disease (risk of priapism) Lymphoproliferative disorders (risk of priapism) Thrombocytopenia Anticoagulants Patients with poor-quality injection technique (patients with psychiatric disorders, obese patients, patients who are blind, and patients with severe arthritis)

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11
Q

Cinacalcet

A

Take with food to increase bioavailability

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12
Q

Mannitol

A

Pulmonary congestion Heart failure Severe renal disease

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13
Q

Calcium acetate & calcium carbonate

A

Interferes with absorption of other drugs including oral iron

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14
Q

Ferrous sulfate and ferric gluconate

A

antacids, proton-pump inhibitors, H2-receptor antagonists (decrease absorption) Do not take with food or with other drugs concurrently (decrease bioavailability)

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15
Q

Finasteride

A

no clinically relevant drug interactions PREGNANCY

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16
Q

Interferes with absorption of other drugs including oral iron

A

Calcium acetate & calcium carbonate

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17
Q

Testosterone replacement

A

Prostate cancer BPH

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18
Q

Anesthetics and neuromuscular blockers due to neuromuscular blockade; overcome by calcium salt administration

A

Aminoglycosides

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19
Q

Nitrates (severe hypotension) Contraindicated in patients at risk of ophthalmologic problems Caution in airplane pilots

A

Sildenafil, tadalafil, vardenafil

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20
Q

Sulfonamide allergies Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)

A

Furosemide

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21
Q

Calcitriol, paricalcitol

A

Cholestyramine (reduces absorption)

22
Q

no clinically relevant drug interactions PREGNANCY

A

Finasteride

23
Q

Contraindicated in patients taking 1. anticoagulants or 2. hormone therapy 1. prolongs bleeding time thus the drug can increase the effect of anticoagulants such as warfarin 2. exhibits antiandrogen and antiestrogenic activity thus it should not be taken with any hormone therapy including oral contraceptive and hormone replacement therapy

A

Saw palmetto

24
Q

Spironolactone; Triamterene; Amiloride

A

Concurrent use with other potassium-sparing diuretics, potassium supplements, ARBs, or ACEIs (hyperkalemia) NSAIDs (decreases efficacy) Anuria

25
Q

should not be used as first-line agents during pregnancy

A

Fluoroquinolones ciprofloxacin, levofloxacin

26
Q

Penicillins - Piperacillin-tazobactam

A

Bacteriostatic agents (e.g., TCN) are antagonistic

27
Q

Aminoglycosides

A

Anesthetics and neuromuscular blockers due to neuromuscular blockade; overcome by calcium salt administration

28
Q

Ethacrynic acid

A

Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)

29
Q

Hydrochlorothiazide and indapamide

A

Sulfonamide allergies Oral hypoglycemics (efficacy decreased) NSAIDs (decreases efficacy) Anuria

30
Q

Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)

A

Ethacrynic acid

31
Q

Sulfonamide allergies COPD

A

Dorzolamide; Acetazolamide

32
Q

Nilutamide

A

respiratory insufficiency Severe hepatic impairment

33
Q

Nitrofurantoin

A

Contraindicated in pregnant patients at term, during labor and delivery, or when onset of labor is imminent; this is due to the possibility of hemolytic anemia in the neonate

34
Q

Contraindicated in pregnant patients at term, during labor and delivery, or when onset of labor is imminent; this is due to the possibility of hemolytic anemia in the neonate

A

Nitrofurantoin

35
Q

Saw palmetto

A

Contraindicated in patients taking 1. anticoagulants or 2. hormone therapy 1. prolongs bleeding time thus the drug can increase the effect of anticoagulants such as warfarin 2. exhibits antiandrogen and antiestrogenic activity thus it should not be taken with any hormone therapy including oral contraceptive and hormone replacement therapy

36
Q

Concurrent use with other potassium-sparing diuretics, potassium supplements, ARBs, or ACEIs (hyperkalemia) NSAIDs (decreases efficacy) Anuria

A

Spironolactone; Triamterene; Amiloride

37
Q

Fluoroquinolones ciprofloxacin, levofloxacin

A

should not be used as first-line agents during pregnancy

38
Q

antacids, proton-pump inhibitors, H2-receptor antagonists (decrease absorption) Do not take with food or with other drugs concurrently (decrease bioavailability)

A

Ferrous sulfate and ferric gluconate

39
Q

Trimethoprim-Sulfamethoxazole

A

Concurrent use with methotrexate, 6-mercaptopurine, and azathioprine–> bone marrow suppression PREGNANCY (can cross placenta)

40
Q

Cholestyramine (reduces absorption)

A

Calcitriol, paricalcitol

41
Q

Bacteriostatic agents (e.g., TCN) are antagonistic

A

Penicillins - Piperacillin-tazobactam

42
Q

Prostate cancer BPH

A

Testosterone replacement

43
Q

Sickle cell disease (risk of priapism) Lymphoproliferative disorders (risk of priapism) Thrombocytopenia Anticoagulants Patients with poor-quality injection technique (patients with psychiatric disorders, obese patients, patients who are blind, and patients with severe arthritis)

A

Alprostadil

44
Q

Severe hepatic impairment

A

Bicalutamide & flutamide Antiandrogens

45
Q

Contraindicated in asthma patients Not effective in AfricanAmerican patients; Avoid nonselective blockers (propanolol) in COPD patients

A

Propranolol

46
Q

Sulfonamide allergies Oral hypoglycemics (efficacy decreased) NSAIDs (decreases efficacy) Anuria

A

Hydrochlorothiazide and indapamide

47
Q

Pulmonary congestion Heart failure Severe renal disease

48
Q

Dutasteride

A

calcium channel blockers (diltiazem and verapamil) inhibit P450 enzymes and can increase levels PREGNANCY

49
Q

Contraindicated for concurrent use with PDE-5 inhibitors such as sildenafil (used for ED) due to increased hypotensive effect Severe liver dysfunction with concurrent use of potent inhibitors of P450 enzymes (e.g., ketoconazole)

A

Alfuzosin, doxazosin, tamsulosin, and terazosin

50
Q

Furosemide

A

Sulfonamide allergies Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)

51
Q

Sildenafil, tadalafil, vardenafil

A

Nitrates (severe hypotension) Contraindicated in patients at risk of ophthalmologic problems Caution in airplane pilots

52
Q

Dorzolamide; Acetazolamide

A

Sulfonamide allergies COPD

Renal Pharm (14 decks)

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