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Renal Pharm > Contraindications > Flashcards

Contraindications Flashcards

1
Q

Alfuzosin, doxazosin, tamsulosin, and terazosin

A

Contraindicated for concurrent use with PDE-5 inhibitors such as sildenafil (used for ED) due to increased hypotensive effect Severe liver dysfunction with concurrent use of potent inhibitors of P450 enzymes (e.g., ketoconazole)

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2
Q

Propranolol

A

Contraindicated in asthma patients Not effective in AfricanAmerican patients; Avoid nonselective blockers (propanolol) in COPD patients

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3
Q

calcium channel blockers (diltiazem and verapamil) inhibit P450 enzymes and can increase levels PREGNANCY

A

Dutasteride

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4
Q

Bicalutamide & flutamide Antiandrogens

A

Severe hepatic impairment

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5
Q

PREGNANCY

A

Captopril, Lisinopril, Enalapril, Ramipril; Losartan, Candesartan, Valsartan, Eprosartan; Aliskiren

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6
Q

respiratory insufficiency Severe hepatic impairment

A

Nilutamide

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7
Q

Captopril, Lisinopril, Enalapril, Ramipril; Losartan, Candesartan, Valsartan, Eprosartan; Aliskiren

A

PREGNANCY

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8
Q

Concurrent use with methotrexate, 6-mercaptopurine, and azathioprine–> bone marrow suppression PREGNANCY (can cross placenta)

A

Trimethoprim-Sulfamethoxazole

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9
Q

Take with food to increase bioavailability

A

Cinacalcet

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10
Q

Alprostadil

A

Sickle cell disease (risk of priapism) Lymphoproliferative disorders (risk of priapism) Thrombocytopenia Anticoagulants Patients with poor-quality injection technique (patients with psychiatric disorders, obese patients, patients who are blind, and patients with severe arthritis)

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11
Q

Cinacalcet

A

Take with food to increase bioavailability

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12
Q

Mannitol

A

Pulmonary congestion Heart failure Severe renal disease

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13
Q

Calcium acetate & calcium carbonate

A

Interferes with absorption of other drugs including oral iron

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14
Q

Ferrous sulfate and ferric gluconate

A

antacids, proton-pump inhibitors, H2-receptor antagonists (decrease absorption) Do not take with food or with other drugs concurrently (decrease bioavailability)

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15
Q

Finasteride

A

no clinically relevant drug interactions PREGNANCY

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16
Q

Interferes with absorption of other drugs including oral iron

A

Calcium acetate & calcium carbonate

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17
Q

Testosterone replacement

A

Prostate cancer BPH

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18
Q

Anesthetics and neuromuscular blockers due to neuromuscular blockade; overcome by calcium salt administration

A

Aminoglycosides

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19
Q

Nitrates (severe hypotension) Contraindicated in patients at risk of ophthalmologic problems Caution in airplane pilots

A

Sildenafil, tadalafil, vardenafil

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20
Q

Sulfonamide allergies Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)

A

Furosemide

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21
Q

Calcitriol, paricalcitol

A

Cholestyramine (reduces absorption)

22
Q

no clinically relevant drug interactions PREGNANCY

A

Finasteride

23
Q

Contraindicated in patients taking 1. anticoagulants or 2. hormone therapy 1. prolongs bleeding time thus the drug can increase the effect of anticoagulants such as warfarin 2. exhibits antiandrogen and antiestrogenic activity thus it should not be taken with any hormone therapy including oral contraceptive and hormone replacement therapy

A

Saw palmetto

24
Q

Spironolactone; Triamterene; Amiloride

A

Concurrent use with other potassium-sparing diuretics, potassium supplements, ARBs, or ACEIs (hyperkalemia) NSAIDs (decreases efficacy) Anuria

25
should not be used as first-line agents during pregnancy
Fluoroquinolones ciprofloxacin, levofloxacin
26
Penicillins - Piperacillin-tazobactam
Bacteriostatic agents (e.g., TCN) are antagonistic
27
Aminoglycosides
Anesthetics and neuromuscular blockers due to neuromuscular blockade; overcome by calcium salt administration
28
Ethacrynic acid
Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)
29
Hydrochlorothiazide and indapamide
Sulfonamide allergies Oral hypoglycemics (efficacy decreased) NSAIDs (decreases efficacy) Anuria
30
Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)
Ethacrynic acid
31
Sulfonamide allergies COPD
Dorzolamide; Acetazolamide
32
Nilutamide
respiratory insufficiency Severe hepatic impairment
33
Nitrofurantoin
Contraindicated in pregnant patients at term, during labor and delivery, or when onset of labor is imminent; this is due to the possibility of hemolytic anemia in the neonate
34
Contraindicated in pregnant patients at term, during labor and delivery, or when onset of labor is imminent; this is due to the possibility of hemolytic anemia in the neonate
Nitrofurantoin
35
Saw palmetto
Contraindicated in patients taking 1. anticoagulants or 2. hormone therapy 1. prolongs bleeding time thus the drug can increase the effect of anticoagulants such as warfarin 2. exhibits antiandrogen and antiestrogenic activity thus it should not be taken with any hormone therapy including oral contraceptive and hormone replacement therapy
36
Concurrent use with other potassium-sparing diuretics, potassium supplements, ARBs, or ACEIs (hyperkalemia) NSAIDs (decreases efficacy) Anuria
Spironolactone; Triamterene; Amiloride
37
Fluoroquinolones ciprofloxacin, levofloxacin
should not be used as first-line agents during pregnancy
38
antacids, proton-pump inhibitors, H2-receptor antagonists (decrease absorption) Do not take with food or with other drugs concurrently (decrease bioavailability)
Ferrous sulfate and ferric gluconate
39
Trimethoprim-Sulfamethoxazole
Concurrent use with methotrexate, 6-mercaptopurine, and azathioprine--\> bone marrow suppression PREGNANCY (can cross placenta)
40
Cholestyramine (reduces absorption)
Calcitriol, paricalcitol
41
Bacteriostatic agents (e.g., TCN) are antagonistic
Penicillins - Piperacillin-tazobactam
42
Prostate cancer BPH
Testosterone replacement
43
Sickle cell disease (risk of priapism) Lymphoproliferative disorders (risk of priapism) Thrombocytopenia Anticoagulants Patients with poor-quality injection technique (patients with psychiatric disorders, obese patients, patients who are blind, and patients with severe arthritis)
Alprostadil
44
Severe hepatic impairment
Bicalutamide & flutamide Antiandrogens
45
Contraindicated in asthma patients Not effective in AfricanAmerican patients; Avoid nonselective blockers (propanolol) in COPD patients
Propranolol
46
Sulfonamide allergies Oral hypoglycemics (efficacy decreased) NSAIDs (decreases efficacy) Anuria
Hydrochlorothiazide and indapamide
47
Pulmonary congestion Heart failure Severe renal disease
Mannitol
48
Dutasteride
calcium channel blockers (diltiazem and verapamil) inhibit P450 enzymes and can increase levels PREGNANCY
49
Contraindicated for concurrent use with PDE-5 inhibitors such as sildenafil (used for ED) due to increased hypotensive effect Severe liver dysfunction with concurrent use of potent inhibitors of P450 enzymes (e.g., ketoconazole)
Alfuzosin, doxazosin, tamsulosin, and terazosin
50
Furosemide
Sulfonamide allergies Aminoglycosides (ototoxicity) NSAIDs (decreases efficacy) Oral hypoglycemics (efficacy decreased)
51
Sildenafil, tadalafil, vardenafil
Nitrates (severe hypotension) Contraindicated in patients at risk of ophthalmologic problems Caution in airplane pilots
52
Dorzolamide; Acetazolamide
Sulfonamide allergies COPD

Renal Pharm (14 decks)

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