Adverse effects rapid review Flashcards

1
Q

neurotoxicity

A

penicillin

cinacalcet secondarty to hypocalcemia

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2
Q

irreversible ototoxicity

A

ethacrynic acid and aminoglycosides

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3
Q

neuromuscular blockade;

A

aminoglycosides; counteracted by calcium salts;

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4
Q

cardiodepresssion

A

verapamil and diltiazem

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5
Q

hot flashes

A
anti androgens (flutamide etc)
LHRH agonists (goserlin etc)
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6
Q

impotence

A

propranolol
alpha 1 adrenergic (tamsolusin etcv)
lhrh agonists

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7
Q

dry mouth

A

clonidine

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8
Q

hyperphosphatemia

A

calcitriol and parcalcitol

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9
Q

soft tissue and vascular calcification

A

calcitriol and paracalcitol

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10
Q

cardiac arrythmias

A

ethacrynic acid; furosemide; thiazide diuretics

due to hypokalemia

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11
Q

increased bone pain and increased urinary symptoms

A

leuprolide and goserelin

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12
Q

nephropathy

A

ceftriaxone
aminoglycosides
alisikren (renal impairment)

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13
Q

acute hemolytic anemia

A

tmp smx

nitrofurantoin due to g6p def

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14
Q

crystalluria

A

tmp smx

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15
Q

steven johnson

A

tmp smx

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16
Q

kernicterus

A

tmp smx

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17
Q

hyperkalemia

A

alisikren
k sparing diuretics
ace inhibitors

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18
Q

edema

A

calcium channel blockers (nifedpine amlo; verapamil, and diltiazem)
diazoxide
minoxidil;pinacidil
test replacement therpary

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19
Q

treat phaechromocytoma

A

labetolol

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20
Q

treat htn in pregnancy

A

methyldopa clonidine

labetolol

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21
Q

treatz; htn for old people

A

calcium channel blockers; all 4

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22
Q

treat htn in pregnancy

A

methyldopa clonidine

labetolol

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23
Q

treatz; htn for old people

A

calcium channel blockers; all 4

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24
Q

treat htn in pregnancy

A

methyldopa clonidine

labetolol

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25
treatz; htn for old people
calcium channel blockers; all 4
26
treat htn in bph
doxazosin and prazosin
27
polycythemia
test replacemtn
28
contact dermatitis
test replacemtn
29
hepatotoxicity
test replacment anti androgens azoles
30
interstitial pneumonitis
nilatumide ONLY; ci for respiratory insuff
31
anaphylaxis
ferric gluconate IV
32
orthostatic hypotension
alpha 1 adrenergic antagonists (tamsolusin ..etc) methyldopa prazosin\doxazosin
33
angioedema
arbs such as losartan | ace inhibitors
34
sudden hearing loss on one side; reversible
sildenafil etc
35
facial flushing; rhinitis; headache
sildenafil etc
36
back and muscle pain
sildenafil due to pde11
37
BROWN urine
Nitrofurantoin
38
hyperlipidemia
Thiazide diuretics
39
hyperuricemia
Thiazide diuretics
40
hypokalemia
loop diuretics Thiazide diuretics causes CARDIAC arythmias
41
accumulation of cyanide byproducts
sodium nitroprusside
42
Rebound hypertension on withdrawal
Clonidine | Propranalol
43
bradycardia; cardiac conduction problems
Propranolol
44
asthma
Propranolol
45
hyperglycemia
Propranolol Thiazide diuretics Loop diuretics
46
hypercalcemia
Calcium acetate/carbonate; Calcitriol; parcalcitol Thiazides
47
dry cough
ACE inhibitors
48
angioedema
ACE inhibitors; | ARBs (--tan)
49
Deep vein thrombosis
Erythropoeinetin growth factor
50
HYPERtension
Erythropoeinetin growth factor
51
Thromboic/vascular events
Erythropoeinetin growth factor
52
Hypotension
besides the antihypertensives | Ferric gluconate
53
IRON overload
Ferric gluconate
54
Gynecomastia
Spironolactone Test replacement Finasteride/Dutasteride Antiandrogens Azoles
55
Rash
Penicillin (ampicillin rash) | Azoles
56
Menstrual irregularities
Azoles
57
Hepatitis
Azoles
58
neurotoxicity such as myoclonus or seizures;
Penicillin
59
Irreversible ototoxicity | Neuromuscular blockade
Aminoglycosides
60
metabolic acidosis WITHOUT hyperkalemia
CA inhibitors; acetazolamide; dorzolamide
61
headache n/v due to hyponatremia
mannitol
62
Endocrine-related including hot flashes, impotence, and decreased libido
Leuprolide | Goserelin
63
used to treat baldness
Minoxidil
64
Headache/flushing; Edema; Tachycardia/Palpitations, & Excessive hair growth
Minoxidil
65
Effective in 2o hypertension due to hyper-aldosteronism
Spironolactone
66
Selective α1-blockade → Arterial dilation
Prazosin; doxazosin
67
Central α2-agonism → ↓ Sympathetic tone
Clonidine
68
Blocks L-type Ca2+ channels → ↓Ca2+ entry
Nifedipine; Amlodipine (Dihydropyridines or DHPs); Verapamil & Diltiazem
69
Opens K+ channels → VSM hyperpolarization & relaxation
Minoxidil
70
Donates nitric oxide → ↑cGMP levels (via guanylate cyclase activation)
Nitroprusside
71
Opens KATP channels → Hyperpolarization & prolonged dilation
Diazoxide
72
Genitourinary: ejaculation disorders (dry sex or delayed ejaculation) and erectile dysfunction
Finasteride | Dutasteride
73
(dry sex or delayed ejaculation)
Finasteride | Dutasteride
74
feminization of a male | fetus
Finasteride | Dutasteride
75
Sudden hearing loss usually on one side | involving partial or complete
Sildenafil, tadalafil, | vardenafil
76
facial flushing, rhinitis (due to | vasodilation)
Sildenafil, tadalafil, | vardenafil
77
Female sexual partners may experience | vaginal burning, itching, or pain
Intraurethral Alprostadil