Contraception and Sterilization - Wootton Flashcards
Function of progesterone component in oral contraceptives
- Suppress LH and ovulation
- Thicken cervical mucous, inhibiting sperm migration
- Creating unfavorable atrophic endometirum
Function of estrogen component in oral contraceptives
- Improve cycle control by stabilizing endometrium and allowing less bleeding
Progestin-only oral contraceptives - fxn
Used by who?
Bad thing about it?
Making cervical mucous thick and impermeable
Breastfeeding women, or those w/ estrogen contraindication
MUST be taken w/in 2-3 hours of same time every day, or else must use backup for 2 days
Benefits of oral contraceptives
- Cycle regularity
- Less dysmenorrhea
- Less iron deficiency
- Less endometrial and ovarian cancer
Benign side effects of oral contraceptives
- Breakthrough bleeding (10-30%)
- Amenorrhea (1-5%)
- Bloating, weight gain, breast tenderness, nausea, fatigue, headache
Serious side effects of oral contraceptives
Venous thrombosis, PE, GB disease, stroke, MI, hepatic tumors
Transdermal patch - caution?
Side effects?
Not effective if > 198 lbs
Same, increased thrombosis risk (more than oral)
Vaginal ring - benefits
Better compliance, less breakthrough bleeding, can be removed for 3 hrs w/o losing efficacy
Groups that can’t use combo contraceptives
- Smokers > 35
- Personal Hx of thromboembolic event
- Hx of CAD, CVD, CHF, or migraine w/ aura
- DM, chronic HTN, SLE
- Moderate to severe liver disease (ex. hepatitis) or tumors
Depo – drug?
How to use?
MoAs
Medroxyprogesterone acetate
IM injection w/in first 5 days of menses, every 3 months
Thicken mucous, decidualize endometrium, block LH and ovulation
Benefit to Depo vs. patch
NOT affected by weight
Depo-provera – black box warning
Important in who?
Bone metabolism issue w/ decreased estrogen level
Adolescents
Side effects of Depo (3)
- Irregular bleeding (add back estrogen to help)
- Weight gain (HANGRY)
- Depression exacerbation (post-partum)
Indications of Depo vs. combo drugs (5)
- No estrogen (can use in contraindication)
- Want better compliance
- Women w/ seizures
- Sickle cell anemia
- Anemia 2º to menorrhagia
Contraindications to Depo (5)
- Pregnancy
- Unknown bleeding
- Breast malignancy
- Active or recent thrombophlebitis/thromboembolic event
- Liver dysfunction/disease
Nexplanon - what is it
Used for how long?
MoA?
Etonogestrel - rod implant
3 years
Thicken mucous, inhibit ovulation