Contraception and Sterilization Flashcards
What are the two general contraceptive mechanisms?
- Inhibit the formation and release of the egg
- Imposing a mechanical, chemical, or temporal barrier between the sperm and the egg
What is looked at when comparing the different methods?
- Method failure rate or the rate inherent in method if used correctly
- Typical failure rate or the rate when the method is actually used by the patient
What are the five basic things you have to think about when choosing a birth control?
- Efficacy
- Safety
- Availability
- Cost
- Acceptability
What are the most effective reversible contraception?
- Hormonal contraceptives
What are the different types of hormonal contracetpives?
- Oral contraceptive pills
- Injectable: Depo medroxyprogesterone acetate
- Implantable: etonogestrel rod implant
- Hormone containing IUD: levonorgestrel
- Contraceptive patches
- Contraceptive rings
How do oral contraceptive pills work?
- Suppress the hypothalamic gonadotropin releasing factors with subsequent suppression of pituitary production of FSH and LH
What does progesterone do in OCP?
- Major player
- Suppresses LH and therefore ovulation as well as thickens the mucosa, inhibiting sperm migration and creating unfavorable atrophic endometrium for implantation
What does estrogen do in OCP?
- Improves cycle control by stabilizing the endometrium and allows less breakthrough bleeding
What are the different ways OCPs are packaged?
- Phasic formations: monophasic and triphasic
- Classic packaging is 21 days of hormones with 7 days of placebo; now could see 24 days of hormones and 4 days of placebo
- Also have continuous regimens versus every 3 month cycling
What is the use of progestin only OCPs?
- Primarily used for making cervical mucous thick and impermeable
- Ovulation continues in 40%
- Mainly used in breastfeeding women and women who have a contraindication to estrogen
What must be done in progestin only OCPs due to the low dose?
- Taken at the same time every day starting on the first day of menses (if late for more than 3 hours, then should use backup method for 48 hours)
What are the benefits of OCPs?
- Menstrual cycle regularity
- Improve dysmenorrhea
- Decrease risk of iron deficiency anemia
- Lower incidence of endometrial and ovarian cancers, benign breast and ovarian disease
What are some mild/moderate side effects of OCPs?
- Breakthrough bleeding
- Amenorrhea
- Bloating
- Weight gain
- Breast tenderness
- Nausea
- Fatigue
- Headache
What severe side effects of OCPs?
- Venous thrombosis
- PE
- Cholestasis and gallbladder disease
- Stroke and MI
- Hepatic tumors
What are some details about the patch?
- Apply one patch weekly for 3 weeks
- Can apply anywhere but breasts
- Caution in use in women over 198 lbs
- Side effects are similar to OCPs but greater risk to thrombosis
What is the ring associated with?
- Greater compliance due to once a month use
- Better tolerance since not going through GI tract and less breakthrough bleeding
Who can’t use hormonal contraceptives?
- Women who smoke and are over 35
- Women with personal history of DVT/PE
- Women with history of CAD, cerebral vascular disease, CHF, or migraine with aura, uncontrolled HTN
- Diabetes, chronic HTN, lupus get individualized prescribing
- Women with moderate to severe liver disease or tumors
How often is depo provera injected?
- Every 11-13 weeks
How long are the levels of progestin maintained after a depo provera injection?
- About 14 weeks
When is the depo provera injected?
- Within first 5 days of menses and if not, use a back up method for 2 weeks
What is the MOA for depo provera injection?
- Thickening of cervical mucosa
- Decidualization of the endometrium
- Blocks LH surge and ovulation
What is the efficacy of depo provera?
- Equivalent to sterilization and not altered by weight
What is the relationship between depo provera and bone density?
- Alterations of bone metabolism associated with decreased estrogen levels
- Particular concern in adolescents
- Reversible after discontinuation
What are some side effects with depo provera?
- Irregular bleeding
- Weight gain
- Exacerbation of depression
How does depo provera affect bleeding?
- Decreases bleeding with use and 80% are amenorrheic after 5 years
- Can improve bleeding profile with short term use of estrogen
- Menses can take up to a year to regulate
What are some indications for depo provera?
- Desire for effective contraception
- Need a method with better compliance
- Breastfeeding
- Can use when estrogen is contraindicated
- Women with seizure disorders
- Sickle cell anemia
- Anemia secondary to menorrhagia
- Endometriosis
- Decrease risk of endometrial hyperplasia
What are some contraindications to depo provera?
- Known or suspected pregnancy
- Unevaluated vaginal bleeding
- Know or suspected malignancy of breast
- Active thrombophlebitis, or current/past history of thromboembolic events or cerebral vascular disease
- Liver dysfunction/disease