Constipation, Hirschprung, Megacolon Flashcards
Definition of constipation:
Infrequent BM <3/wk for 12 mo AND at least 25% of time: straining feeling of incomplete evacuation hard stool
In normal colon, motor function depends on contraction of
circular layer of smooth muscle
3 patterns of contractions:
short duration
long duration
giant migrating complexes
How are short duration colonic contractions characterized?
stationary motor contr, present over short areas of colon + persisting for <15s
What is the physiologic function of short duration colonic contractions?
mixing of fecal material and extraction of water
How are long duration colonic contractions characterized?
stationary or propagating (short distances) contractions, which may travel in orad or aboral direction
What is the physiologic function of long duration colonic contractions?
Assists in mixing and local propulsion of feces
long duration colonic contractions cause migration towards:
rectum in distal colon
How are giant migrating complexes of the colon characterized?
aboral propagating over extended distances
What is the physiologic purpose of giant migrating complexes of the colon?
causes mass movement of feces
Giant migrating complexes of the colon normally occur ____ (how freq?), and may be precipitated by:
1-2 times per day
colonic distention
How does food affect colonic motility?
causes increased segmental activity
Gastro-colic reflux may be mediated by:
CCK
Motility in response to food intake is proportional to:
caloric content of meal
CCK causes:
increased frequency & amplitude of segmental contractions
PgF stimulates:
longitudinal muscle contraction
PgE inh:
circular muscle contraction
Serotonin mediates:
intestinal peristalsis
secretion in GI tract
modulation of pain perception
Serotonin is released by:
__% of serotonin is located in GIT
enterochromaffin cells
80
What do 5HT3-R antagonists treat?
IBS pain
functional dyspepsia
2 types of constipation?
functional
IBS-C
Constipation is more common in pts with:
little daily physical activity
low income
poor education