Connective Tissue Revision Questions

Question 1

Antibodies present in autoimmune

Answer 1

Anti Ro, Anti La, anti nuclear
anti double stranded RNA
anti centromere, ant SCL 70
Antineutrophil cytoplasmic

Question 2

Systemic lupus erythemitosis

Answer 2

organ changes and antibodies
anti nuclear, anti double stranded DNA and anti Ro
affects joints, skin, kidney, blood, muscles
Common women of child bearing age and CVS risk
butterfly zygomatic rush, raynauds pehnomenon, heart problems, arthritis

Question 3

Dental aspects of systemic lupus

Answer 3

chronic aneamia - GA risk and oral ulcerations
bleeding tendency due to thrombocytopenia
renal disease - impaired drug metabolism
lichnoid reactions
steroids and immunosupression
oral pigmentation from hydroxychloroquine

Question 4

Antiphospolipid antibody syndrome

Answer 4

marker in blood called lupus anticogulant

recurrent thrombosis - DVT with pulmonary embolism - on warfarin

Question 5

Sjorens syndrome

Answer 5

inflammatory disease assoicated with circulating antibodies
not caused by them (anti Ro, LA and anti nuclear)
involves salivary glands

Signs - dry eyes and mouth

Question 6

Dental aspects of sjorens syndrome

Answer 6

Oral infection, caries, denture retention
sialosis (swelling of salivary gland)
salivary lymphoma

Question 7

Sysyemic sclerosis

Answer 7

excessive collagen deposition, connective tissue fibrosis and loss of elastic tissue

Features - raynauds, osephagus might not stretch for food and gut not allow easy peristailis

Question 8

Dental aspects of systemic sclerosis

Answer 8

limited mouth opening, poor oral access, limtied tongue movement
Reflux so erosion likely
widening of PDL but no tooth movement

Question 9

Vasculitis

Answer 9

inflammation of blood vessels

Question 10

Giant cell artierties

Answer 10

headache and facial pain present

involves other carotid branches - chewing claudication occlusion of central retinal artery

Question 11

Polymyalgia Rhemiumatica

Answer 11

elederly - large blood vessels affected
pain and morning stiffness
responds to steroids
malliase, weight loss, fatigue

Question 12

Kawaski Disease

Answer 12

occurs in children
fever, lymphadenopathy, cracked tongue
strawberry tongue, erythemetous mucosa, 
peeling rash on hands and feet
coronary vessel anerysums - may need antibiotic prophylaxis

Question 13

Wegner’s Granulomatosis

Answer 13

Inflammatory - can lead to distruction of hard and soft tissue of face and oral cavity
Spongy red tissue
renal and respratory affected

Question 14

Fibromylgia

Answer 14

symptoms but no evidence of acute disease

joint and muscle pain, functional disorders