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MSS > Connective Tissue Histology > Flashcards

Connective Tissue Histology Flashcards

1
Q

What is the origin, morphology, and function of a fibroblast?

A

Immobile cells that release structural proteins (collagen, elastin, reticulin)

Large, ovoid or stellate cells with long tapering processes that branch

Mesoderm

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2
Q

What is the origin, morphology, and function of a macrophage?

A

Mobile phagocytic cells that engulf foreign material or organisms

Moderately large, mostly round shape. Spherical or indented nucleus

Bone marrow

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3
Q

What is the origin, morphology, and function of a mast cell?

A

Cells near blood vessels that release histamine and other inflammatory mediators

Grapes

Mesoderm

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4
Q

What is the origin, morphology, and function of a plasma cell?

A

Mobile cells that secrete antibodies, immunity cells

Clock face

Bone marrow

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5
Q

What is the origin, morphology, and function of a white adipose cells?

A

Immobile - Energy storage, protect and insulate structures

Fatty white

Mesoderm

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6
Q

What is the origin, morphology, and function of a brown adipose cells?

A

Immobile - Heat generation

Fatty yellow

Mesoderm

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7
Q

What is the origin, morphology, and function of reticular cells?

A

Immobile - Fibroblasts that secrete reticular fibers (Collagen type 3)

Large, ovoid or stellate cells with long tapering processes that branch

Mesoderm

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8
Q

What is the most abundant component of connective tissue?

A

Collagen

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9
Q

What is the structure of collagen?

A

helix with two subunits

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10
Q

What disease is caused by a deficiency of vitamin C?

A

Scurvy - collagen can’t be formed

Causes teeth and gum issues

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11
Q

What is Ehlers-Danlos Syndrome?

A

genetic defect of the collagen fibrils, results in hyper elastic skin and joints

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12
Q

What is Osteogenesis Imperfecta?

A

Brittle bone disease - Genetic defect in type 1 collagen

Often causes blue sclera of the eye

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13
Q

What is the function of elastic connective tissue?

A

Stretching and expanding in tissue

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14
Q

Elastic fibers contain what fibrils/bundles?

A

Fibrillin and Fibullin (glycoproteins) and elastin

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15
Q

What causes Marfan syndrome? What are the risks?

A

Genetic issue leading to abnormal fibrillin, prevents elastic fiber deposition

Often leads to issues I the tunica media of the aorta (can rupture)

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16
Q

Who may have had Marfans Syndrome?

A

Abe Lincoln

17
Q

What is the function of reticular fibers and where are they commonly found?

A

Lymphatic tissues - supportive framework/meshwork of many organs

Produces type 3 collagen

18
Q

What is amorphous ground substance, what makes it?

A

Fibroblasts makes AGS, contains glycosaminoglycans and glycoproteins

19
Q

What are the 2 types of embryonic connective tissue?

A
  1. Mesenchyme

2. Mucous connective tissue (Wharton’s jelly). found in the neonatal umbilical region

20
Q

What are the 2 types of adult connective tissue? Where are they found? Which one is most widespread?

A
  1. Loose (areolar) - tubular organs, most widespread

Swelling takes place in this tissue

  1. Dense irregular - periosteum, dermis, organ capsule
  2. Dense regular - tendons, ligaments, cornea; single direction of collagen fibers
21
Q

What is mixed connective disease?

A

Sharp syndrome - young women most common, fatigue, fever, joint swelling

Autoimmune disorder that attacks connective tissue

22
Q

What is fibrosis?

A

Overgrowth of connective tissue, causes scarring - often leads to organ issues or failure

23
Q

What is sarcoma?

A

Cancer of connective tissue

24
Q

What is multiple myeloma?

A

Plasma cell malignancy - plasma cells accumulate in bone marrow

25
Q

What is lipoma?

A

Fat malignancy, matter unilocular adipocytes that resemble normal adipose tissue (just overgrown)

26
Q

What is scleroderma?

A

Autoimmune issue - Overproduction of collagen, disrupts normal architecture

27
Q

What is inflammation?

A

Cellular response to cell injury

28
Q

What is obesity?

A

Increase in adipose tissue beyond the bodies needs

29
Q

What is tendinitis?

A

Inflammation of tendon sheath - hard to treat because sheath has little blood supply

30
Q

What is a hibernoma?

A

Brown adipose tissue tumor, can compress structures

31
Q

What is a liposarcoma?

A

Malignant adipose tumor that metastasize to other tissues

MSS (7 decks)

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